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GDI2 (GDP dissociation inhibitor 2)

Identity

Alias_symbol (synonym)RABGDIB
Other aliasHEL-S-46e
HGNC (Hugo) GDI2
LocusID (NCBI) 2665
Atlas_Id 43809
Location 10p15.1  [Link to chromosome band 10p15]
Location_base_pair Starts at 5765223 and ends at 5813549 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C2orf61 (2p21) / GDI2 (10p15.1)EHF (11p13) / GDI2 (10p15.1)GDI2 (10p15.1) / CPVL (7p14.3)
GDI2 (10p15.1) / GDI2 (10p15.1)GDI2 (10p15.1) / GRAMD1C (3q13.31)GDI2 (10p15.1) / NDUFB7 (19p13.12)
GDI2 (10p15.1) / ZNF526 (19q13.2)KRT13 (17q21.2) / GDI2 (10p15.1)PRAME (22q11.22) / GDI2 (10p15.1)
RABGGTB (1p31.1) / GDI2 (10p15.1)GDI2 10p15.1 / CPVL 7p14.3GDI2 10p15.1 / ZNF526 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GDI2   4227
Cards
Entrez_Gene (NCBI)GDI2  2665  GDP dissociation inhibitor 2
AliasesHEL-S-46e; RABGDIB
GeneCards (Weizmann)GDI2
Ensembl hg19 (Hinxton)ENSG00000057608 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000057608 [Gene_View]  chr10:5765223-5813549 [Contig_View]  GDI2 [Vega]
ICGC DataPortalENSG00000057608
TCGA cBioPortalGDI2
AceView (NCBI)GDI2
Genatlas (Paris)GDI2
WikiGenes2665
SOURCE (Princeton)GDI2
Genetics Home Reference (NIH)GDI2
Genomic and cartography
GoldenPath hg38 (UCSC)GDI2  -     chr10:5765223-5813549 -  10p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GDI2  -     10p15.1   [Description]    (hg19-Feb_2009)
EnsemblGDI2 - 10p15.1 [CytoView hg19]  GDI2 - 10p15.1 [CytoView hg38]
Mapping of homologs : NCBIGDI2 [Mapview hg19]  GDI2 [Mapview hg38]
OMIM600767   
Gene and transcription
Genbank (Entrez)AB451295 AB451429 AF144713 AK094671 AK122841
RefSeq transcript (Entrez)NM_001115156 NM_001494
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GDI2
Cluster EST : UnigeneHs.299055 [ NCBI ]
CGAP (NCI)Hs.299055
Alternative Splicing GalleryENSG00000057608
Gene ExpressionGDI2 [ NCBI-GEO ]   GDI2 [ EBI - ARRAY_EXPRESS ]   GDI2 [ SEEK ]   GDI2 [ MEM ]
Gene Expression Viewer (FireBrowse)GDI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2665
GTEX Portal (Tissue expression)GDI2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50395   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50395  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50395
Splice isoforms : SwissVarP50395
PhosPhoSitePlusP50395
Domains : Interpro (EBI)FAD/NAD-binding_dom    GDP_dissociation_inhibitor    RabGDI   
Domain families : Pfam (Sanger)GDI (PF00996)   
Domain families : Pfam (NCBI)pfam00996   
Conserved Domain (NCBI)GDI2
DMDM Disease mutations2665
Blocks (Seattle)GDI2
SuperfamilyP50395
Human Protein AtlasENSG00000057608
Peptide AtlasP50395
HPRD02863
IPIIPI00940148   IPI00031461   IPI00514395   IPI00640006   IPI00513929   IPI00645255   
Protein Interaction databases
DIP (DOE-UCLA)P50395
IntAct (EBI)P50395
FunCoupENSG00000057608
BioGRIDGDI2
STRING (EMBL)GDI2
ZODIACGDI2
Ontologies - Pathways
QuickGOP50395
Ontology : AmiGORNA binding  Rab GDP-dissociation inhibitor activity  GTPase activator activity  protein binding  extracellular region  cytoplasm  Golgi apparatus  cytosol  focal adhesion  signal transduction  small GTPase mediated signal transduction  protein transport  membrane  oxidoreductase activity  small GTPase binding  vesicle  secretory granule lumen  azurophil granule lumen  myelin sheath  neutrophil degranulation  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  oxidation-reduction process  membrane organization  extracellular exosome  
Ontology : EGO-EBIRNA binding  Rab GDP-dissociation inhibitor activity  GTPase activator activity  protein binding  extracellular region  cytoplasm  Golgi apparatus  cytosol  focal adhesion  signal transduction  small GTPase mediated signal transduction  protein transport  membrane  oxidoreductase activity  small GTPase binding  vesicle  secretory granule lumen  azurophil granule lumen  myelin sheath  neutrophil degranulation  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  oxidation-reduction process  membrane organization  extracellular exosome  
NDEx NetworkGDI2
Atlas of Cancer Signalling NetworkGDI2
Wikipedia pathwaysGDI2
Orthology - Evolution
OrthoDB2665
GeneTree (enSembl)ENSG00000057608
Phylogenetic Trees/Animal Genes : TreeFamGDI2
HOVERGENP50395
HOGENOMP50395
Homologs : HomoloGeneGDI2
Homology/Alignments : Family Browser (UCSC)GDI2
Gene fusions - Rearrangements
Fusion : MitelmanGDI2/CPVL [10p15.1/7p14.3]  
Fusion : MitelmanGDI2/ZNF526 [10p15.1/19q13.2]  [t(10;19)(p15;q13)]  
Fusion: TCGAGDI2 10p15.1 CPVL 7p14.3 LGG
Fusion: TCGAGDI2 10p15.1 ZNF526 19q13.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGDI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GDI2
dbVarGDI2
ClinVarGDI2
1000_GenomesGDI2 
Exome Variant ServerGDI2
ExAC (Exome Aggregation Consortium)GDI2 (select the gene name)
Genetic variants : HAPMAP2665
Genomic Variants (DGV)GDI2 [DGVbeta]
DECIPHERGDI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGDI2 
Mutations
ICGC Data PortalGDI2 
TCGA Data PortalGDI2 
Broad Tumor PortalGDI2
OASIS PortalGDI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGDI2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGDI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GDI2
DgiDB (Drug Gene Interaction Database)GDI2
DoCM (Curated mutations)GDI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GDI2 (select a term)
intoGenGDI2
Cancer3DGDI2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600767   
Orphanet
MedgenGDI2
Genetic Testing Registry GDI2
NextProtP50395 [Medical]
TSGene2665
GENETestsGDI2
Target ValidationGDI2
Huge Navigator GDI2 [HugePedia]
snp3D : Map Gene to Disease2665
BioCentury BCIQGDI2
ClinGenGDI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2665
Chemical/Pharm GKB GenePA28642
Clinical trialGDI2
Miscellaneous
canSAR (ICR)GDI2 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGDI2
EVEXGDI2
GoPubMedGDI2
iHOPGDI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:35:04 CEST 2017

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