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GDI2 (GDP dissociation inhibitor 2)

Identity

Alias (NCBI)HEL-S-46e
RABGDIB
HGNC (Hugo) GDI2
HGNC Alias symbRABGDIB
HGNC Alias namerab GDP-dissociation
LocusID (NCBI) 2665
Atlas_Id 43809
Location 10p15.1  [Link to chromosome band 10p15]
Location_base_pair Starts at 5765223 and ends at 5813434 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2orf61 (2p21) / GDI2 (10p15.1)EHF (11p13) / GDI2 (10p15.1)GDI2 (10p15.1) / CPVL (7p14.3)
GDI2 (10p15.1) / GDI2 (10p15.1)GDI2 (10p15.1) / GRAMD1C (3q13.31)GDI2 (10p15.1) / NDUFB7 (19p13.12)
GDI2 (10p15.1) / ZNF526 (19q13.2)KRT13 (17q21.2) / GDI2 (10p15.1)PRAME (22q11.22) / GDI2 (10p15.1)
RABGGTB (1p31.1) / GDI2 (10p15.1)GDI2 10p15.1 / CPVL 7p14.3GDI2 10p15.1 / ZNF526 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GDI2   4227
Cards
Entrez_Gene (NCBI)GDI2    GDP dissociation inhibitor 2
AliasesHEL-S-46e; RABGDIB
GeneCards (Weizmann)GDI2
Ensembl hg19 (Hinxton)ENSG00000057608 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000057608 [Gene_View]  ENSG00000057608 [Sequence]  chr10:5765223-5813434 [Contig_View]  GDI2 [Vega]
ICGC DataPortalENSG00000057608
TCGA cBioPortalGDI2
AceView (NCBI)GDI2
Genatlas (Paris)GDI2
SOURCE (Princeton)GDI2
Genetics Home Reference (NIH)GDI2
Genomic and cartography
GoldenPath hg38 (UCSC)GDI2  -     chr10:5765223-5813434 -  10p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GDI2  -     10p15.1   [Description]    (hg19-Feb_2009)
GoldenPathGDI2 - 10p15.1 [CytoView hg19]  GDI2 - 10p15.1 [CytoView hg38]
ImmunoBaseENSG00000057608
Genome Data Viewer NCBIGDI2 [Mapview hg19]  
OMIM600767   
Gene and transcription
Genbank (Entrez)AB451295 AB451429 AF144713 AK094671 AK122841
RefSeq transcript (Entrez)NM_001115156 NM_001494
Consensus coding sequences : CCDS (NCBI)GDI2
Gene ExpressionGDI2 [ NCBI-GEO ]   GDI2 [ EBI - ARRAY_EXPRESS ]   GDI2 [ SEEK ]   GDI2 [ MEM ]
Gene Expression Viewer (FireBrowse)GDI2 [ Firebrowse - Broad ]
GenevisibleExpression of GDI2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2665
GTEX Portal (Tissue expression)GDI2
Human Protein AtlasENSG00000057608-GDI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50395   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50395  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50395
PhosPhoSitePlusP50395
Domains : Interpro (EBI)FAD/NAD-bd_sf    GDP_dissociation_inhibitor    RabGDI   
Domain families : Pfam (Sanger)GDI (PF00996)   
Domain families : Pfam (NCBI)pfam00996   
Conserved Domain (NCBI)GDI2
SuperfamilyP50395
AlphaFold pdb e-kbP50395   
Human Protein Atlas [tissue]ENSG00000057608-GDI2 [tissue]
HPRD02863
Protein Interaction databases
DIP (DOE-UCLA)P50395
IntAct (EBI)P50395
BioGRIDGDI2
STRING (EMBL)GDI2
ZODIACGDI2
Ontologies - Pathways
QuickGOP50395
Ontology : AmiGORNA binding  Rab GDP-dissociation inhibitor activity  GTPase activator activity  protein binding  extracellular region  cytoplasm  cytoplasm  cytosol  focal adhesion  signal transduction  small GTPase mediated signal transduction  protein transport  membrane  vesicle-mediated transport  small GTPase binding  vesicle  secretory granule lumen  azurophil granule lumen  neutrophil degranulation  synapse  regulation of catalytic activity  extracellular exosome  
Ontology : EGO-EBIRNA binding  Rab GDP-dissociation inhibitor activity  GTPase activator activity  protein binding  extracellular region  cytoplasm  cytoplasm  cytosol  focal adhesion  signal transduction  small GTPase mediated signal transduction  protein transport  membrane  vesicle-mediated transport  small GTPase binding  vesicle  secretory granule lumen  azurophil granule lumen  neutrophil degranulation  synapse  regulation of catalytic activity  extracellular exosome  
NDEx NetworkGDI2
Atlas of Cancer Signalling NetworkGDI2
Wikipedia pathwaysGDI2
Orthology - Evolution
OrthoDB2665
GeneTree (enSembl)ENSG00000057608
Phylogenetic Trees/Animal Genes : TreeFamGDI2
Homologs : HomoloGeneGDI2
Homology/Alignments : Family Browser (UCSC)GDI2
Gene fusions - Rearrangements
Fusion : MitelmanGDI2/CPVL [10p15.1/7p14.3]  
Fusion : MitelmanGDI2/ZNF526 [10p15.1/19q13.2]  
Fusion : QuiverGDI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGDI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GDI2
dbVarGDI2
ClinVarGDI2
MonarchGDI2
1000_GenomesGDI2 
Exome Variant ServerGDI2
GNOMAD BrowserENSG00000057608
Varsome BrowserGDI2
ACMGGDI2 variants
VarityP50395
Genomic Variants (DGV)GDI2 [DGVbeta]
DECIPHERGDI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGDI2 
Mutations
ICGC Data PortalGDI2 
TCGA Data PortalGDI2 
Broad Tumor PortalGDI2
OASIS PortalGDI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGDI2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGDI2
Mutations and Diseases : HGMDGDI2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGDI2
DgiDB (Drug Gene Interaction Database)GDI2
DoCM (Curated mutations)GDI2
CIViC (Clinical Interpretations of Variants in Cancer)GDI2
Cancer3DGDI2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600767   
Orphanet
DisGeNETGDI2
MedgenGDI2
Genetic Testing Registry GDI2
NextProtP50395 [Medical]
GENETestsGDI2
Target ValidationGDI2
Huge Navigator GDI2 [HugePedia]
ClinGenGDI2
Clinical trials, drugs, therapy
MyCancerGenomeGDI2
Protein Interactions : CTDGDI2
Pharm GKB GenePA28642
PharosP50395
Clinical trialGDI2
Miscellaneous
canSAR (ICR)GDI2
HarmonizomeGDI2
DataMed IndexGDI2
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGDI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:10:36 CEST 2021

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