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GDNF (glial cell derived neurotrophic factor)

Identity

Other namesATF1
ATF2
HFB1-GDNF
HSCR3
HGNC (Hugo) GDNF
LocusID (NCBI) 2668
Location 5p13.2
Location_base_pair Starts at 37812779 and ends at 37839782 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GDNF   4232
Cards
Entrez_Gene (NCBI)GDNF  2668  glial cell derived neurotrophic factor
GeneCards (Weizmann)GDNF
Ensembl (Hinxton)ENSG00000168621 [Gene_View]  chr5:37812779-37839782 [Contig_View]  GDNF [Vega]
ICGC DataPortalENSG00000168621
AceView (NCBI)GDNF
Genatlas (Paris)GDNF
WikiGenes2668
SOURCE (Princeton)NM_000514 NM_001190468 NM_001190469 NM_001278098 NM_199231 NM_199234
Genomic and cartography
GoldenPath (UCSC)GDNF  -  5p13.2   chr5:37812779-37839782 -  5p13.2   [Description]    (hg19-Feb_2009)
EnsemblGDNF - 5p13.2 [CytoView]
Mapping of homologs : NCBIGDNF [Mapview]
OMIM171300   209880   600837   613711   
Gene and transcription
Genbank (Entrez)AF053748 AJ001897 AJ001898 AJ001899 AJ001900
RefSeq transcript (Entrez)NM_000514 NM_001190468 NM_001190469 NM_001278098 NM_199231 NM_199234
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_011675 NT_006576 NW_001838933 NW_004929321
Consensus coding sequences : CCDS (NCBI)GDNF
Cluster EST : UnigeneHs.248114 [ NCBI ]
CGAP (NCI)Hs.248114
Alternative Splicing : Fast-db (Paris)GSHG0024731
Alternative Splicing GalleryENSG00000168621
Gene ExpressionGDNF [ NCBI-GEO ]     GDNF [ SEEK ]   GDNF [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP39905 (Uniprot)
NextProtP39905  [Medical]
With graphics : InterProP39905
Splice isoforms : SwissVarP39905 (Swissvar)
Domaine pattern : Prosite (Expaxy)TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    GDNF    TGF-b_C   
Related proteins : CluSTrP39905
Domain families : Pfam (Sanger)TGF_beta (PF00019)   
Domain families : Pfam (NCBI)pfam00019   
Domain families : Smart (EMBL)TGFB (SM00204)  
DMDM Disease mutations2668
Blocks (Seattle)P39905
PDB (SRS)2V5E    3FUB   
PDB (PDBSum)2V5E    3FUB   
PDB (IMB)2V5E    3FUB   
PDB (RSDB)2V5E    3FUB   
Human Protein AtlasENSG00000168621
Peptide AtlasP39905
HPRD02906
IPIIPI00026858   IPI00375525   IPI00848254   IPI00848296   IPI00903066   IPI00965059   
Protein Interaction databases
DIP (DOE-UCLA)P39905
IntAct (EBI)P39905
FunCoupENSG00000168621
BioGRIDGDNF
InParanoidP39905
Interologous Interaction database P39905
IntegromeDBGDNF
STRING (EMBL)GDNF
Ontologies - Pathways
Ontology : AmiGOmetanephros development  branching involved in ureteric bud morphogenesis  neural crest cell migration  organ induction  postsynaptic membrane organization  mesenchymal to epithelial transition involved in metanephros morphogenesis  receptor binding  extracellular region  signal transduction  nervous system development  axon guidance  growth factor activity  adult locomotory behavior  postganglionic parasympathetic nervous system development  peristalsis  neuron projection development  positive regulation of monooxygenase activity  positive regulation of dopamine secretion  protein homodimerization activity  negative regulation of apoptotic process  negative regulation of neuron apoptotic process  positive regulation of transcription from RNA polymerase II promoter  mRNA stabilization  enteric nervous system development  sympathetic nervous system development  regulation of dopamine uptake involved in synaptic transmission  ureteric bud formation  regulation of morphogenesis of a branching structure  positive regulation of ureteric bud formation  positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  positive regulation of branching involved in ureteric bud morphogenesis  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBImetanephros development  branching involved in ureteric bud morphogenesis  neural crest cell migration  organ induction  postsynaptic membrane organization  mesenchymal to epithelial transition involved in metanephros morphogenesis  receptor binding  extracellular region  signal transduction  nervous system development  axon guidance  growth factor activity  adult locomotory behavior  postganglionic parasympathetic nervous system development  peristalsis  neuron projection development  positive regulation of monooxygenase activity  positive regulation of dopamine secretion  protein homodimerization activity  negative regulation of apoptotic process  negative regulation of neuron apoptotic process  positive regulation of transcription from RNA polymerase II promoter  mRNA stabilization  enteric nervous system development  sympathetic nervous system development  regulation of dopamine uptake involved in synaptic transmission  ureteric bud formation  regulation of morphogenesis of a branching structure  positive regulation of ureteric bud formation  positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  positive regulation of branching involved in ureteric bud morphogenesis  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Protein Interaction DatabaseGDNF
Wikipedia pathwaysGDNF
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GDNF
SNP (GeneSNP Utah)GDNF
SNP : HGBaseGDNF
Genetic variants : HAPMAPGDNF
1000_GenomesGDNF 
ICGC programENSG00000168621 
CONAN: Copy Number AnalysisGDNF 
Somatic Mutations in Cancer : COSMICGDNF 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDGDNF
OMIM171300    209880    600837    613711   
MedgenGDNF
GENETestsGDNF
Disease Genetic AssociationGDNF
Huge Navigator GDNF [HugePedia]  GDNF [HugeCancerGEM]
Genomic VariantsGDNF  GDNF [DGVbeta]
Exome VariantGDNF
dbVarGDNF
ClinVarGDNF
snp3D : Map Gene to Disease2668
General knowledge
Homologs : HomoloGeneGDNF
Homology/Alignments : Family Browser (UCSC)GDNF
Phylogenetic Trees/Animal Genes : TreeFamGDNF
Chemical/Protein Interactions : CTD2668
Chemical/Pharm GKB GenePA28644
Clinical trialGDNF
Cancer Resource (Charite)ENSG00000168621
Other databases
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
CoreMineGDNF
iHOPGDNF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:48:06 CEST 2014

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