GEM (GTP binding protein overexpressed in skeletal muscle)

2004-05-01  

Identity

HGNC
GEM
LOCATION
8q22.1
LOCUSID
2669
ALIAS
KIR

Other Information

Locus ID:

NCBI: 2669
MIM: 600164
HGNC: 4234
Ensembl: ENSG00000164949

Variants:

dbSNP: 2669
ClinVar: 2669
TCGA: ENSG00000164949
COSMIC: GEM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164949ENST00000297596P55040
ENSG00000164949ENST00000297596A0A024R9F5
ENSG00000164949ENST00000396194P55040
ENSG00000164949ENST00000396194A0A024R9F5
ENSG00000164949ENST00000523433E5RJF9

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
162429322005The RGK family: a regulatory tail of small GTP-binding proteins.17
245861482014Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission.17
171079482007Biochemical and structural characterization of the gem GTPase.16
170527162006Structure-function studies of the G-domain from human gem, a novel small G-protein.14
202339272010A systemic network for Chlamydia pneumoniae entry into human cells.14
229643042012The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression.8
225895332012Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels.6
251738852014Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.4
310132882019Identification of key regulatory genes connected to NF-κB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network.4
251557512014Identification of Gem as a new candidate prognostic marker in hepatocellular carcinoma.2

Citation

Dessen P

GEM (GTP binding protein overexpressed in skeletal muscle)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/276/gem