GEMIN2 (gem nuclear organelle associated protein 2)

2011-08-01  

Identity

HGNC
LOCATION
14q21.1
LOCUSID
ALIAS
SIP1,SIP1-delta
FUSION GENES

Other Information

Locus ID:

NCBI: 8487
MIM: 602595
HGNC: 10884
Ensembl: ENSG00000092208

Variants:

dbSNP: 8487
ClinVar: 8487
TCGA: ENSG00000092208
COSMIC: GEMIN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092208ENST00000250379O14893
ENSG00000092208ENST00000308317O14893
ENSG00000092208ENST00000396249O14893
ENSG00000092208ENST00000412033O14893
ENSG00000092208ENST00000524781S4R421
ENSG00000092208ENST00000525153G5EA29
ENSG00000092208ENST00000527381H0YDP6
ENSG00000092208ENST00000531684H0YCF4
ENSG00000092208ENST00000534684H0YEL0
ENSG00000092208ENST00000650481A0A3B3IU42

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Survival motor neuron (SMN) complexKEGGhsa_M00426
Survival motor neuron (SMN) complexKEGGM00426
Gene ExpressionREACTOMER-HSA-74160
Metabolism of non-coding RNAREACTOMER-HSA-194441
snRNP AssemblyREACTOMER-HSA-191859

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159648102005The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy.86
218162742011Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.43
167319052006Identification of a novel human immunodeficiency virus type 1 integrase interactor, Gemin2, that facilitates efficient viral cDNA synthesis in vivo.30
219130132012Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy.26
198305592010MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells.25
268289622016A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange.25
173083082007Gemin2 plays an important role in stabilizing the survival of motor neuron complex.24
199156602009Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 Is critical for HIV-1 infection.21
198063222010Identification of the role of Smad interacting protein 1 (SIP1) in glioma.15
205156822010Novel monoclonal antibodies detect Smad-interacting protein 1 (SIP1) in the cytoplasm of human cells from multiple tumor tissue arrays.14

Citation

Dessen P

GEMIN2 (gem nuclear organelle associated protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52343/gemin2