Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GEN1 (GEN1, Holliday junction 5' flap endonuclease)

Identity

Alias_namesGen endonuclease homolog 1 (Drosophila)
Alias_symbol (synonym)FLJ40869
Gen
Other alias
HGNC (Hugo) GEN1
LocusID (NCBI) 348654
Atlas_Id 42931
Location 2p24.2  [Link to chromosome band 2p24]
Location_base_pair Starts at 17754160 and ends at 17785913 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GEN1   26881
Cards
Entrez_Gene (NCBI)GEN1  348654  GEN1, Holliday junction 5' flap endonuclease
AliasesGen
GeneCards (Weizmann)GEN1
Ensembl hg19 (Hinxton)ENSG00000178295 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178295 [Gene_View]  chr2:17754160-17785913 [Contig_View]  GEN1 [Vega]
ICGC DataPortalENSG00000178295
TCGA cBioPortalGEN1
AceView (NCBI)GEN1
Genatlas (Paris)GEN1
WikiGenes348654
SOURCE (Princeton)GEN1
Genetics Home Reference (NIH)GEN1
Genomic and cartography
GoldenPath hg38 (UCSC)GEN1  -     chr2:17754160-17785913 +  2p24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GEN1  -     2p24.2   [Description]    (hg19-Feb_2009)
EnsemblGEN1 - 2p24.2 [CytoView hg19]  GEN1 - 2p24.2 [CytoView hg38]
Mapping of homologs : NCBIGEN1 [Mapview hg19]  GEN1 [Mapview hg38]
OMIM612449   
Gene and transcription
Genbank (Entrez)AK025489 AK093631 AK098188 AK131387 BC035863
RefSeq transcript (Entrez)NM_001130009 NM_182625
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GEN1
Cluster EST : UnigeneHs.467793 [ NCBI ]
CGAP (NCI)Hs.467793
Alternative Splicing GalleryENSG00000178295
Gene ExpressionGEN1 [ NCBI-GEO ]   GEN1 [ EBI - ARRAY_EXPRESS ]   GEN1 [ SEEK ]   GEN1 [ MEM ]
Gene Expression Viewer (FireBrowse)GEN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)348654
GTEX Portal (Tissue expression)GEN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ17RS7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ17RS7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ17RS7
Splice isoforms : SwissVarQ17RS7
PhosPhoSitePlusQ17RS7
Domains : Interpro (EBI)5-3_exonuclease_C    HhH2    PIN_domain-like    XPG-I_dom    XPG/Rad2    XPG_DNA_repair_N   
Domain families : Pfam (Sanger)XPG_I (PF00867)    XPG_N (PF00752)   
Domain families : Pfam (NCBI)pfam00867    pfam00752   
Domain families : Smart (EMBL)HhH2 (SM00279)  XPGI (SM00484)  XPGN (SM00485)  
Conserved Domain (NCBI)GEN1
DMDM Disease mutations348654
Blocks (Seattle)GEN1
PDB (SRS)5T9J   
PDB (PDBSum)5T9J   
PDB (IMB)5T9J   
PDB (RSDB)5T9J   
Structural Biology KnowledgeBase5T9J   
SCOP (Structural Classification of Proteins)5T9J   
CATH (Classification of proteins structures)5T9J   
SuperfamilyQ17RS7
Human Protein AtlasENSG00000178295
Peptide AtlasQ17RS7
HPRD08813
IPIIPI00295818   IPI01015317   IPI00982888   IPI00978436   IPI00978022   
Protein Interaction databases
DIP (DOE-UCLA)Q17RS7
IntAct (EBI)Q17RS7
FunCoupENSG00000178295
BioGRIDGEN1
STRING (EMBL)GEN1
ZODIACGEN1
Ontologies - Pathways
QuickGOQ17RS7
Ontology : AmiGOdouble-strand break repair via homologous recombination  DNA binding  endodeoxyribonuclease activity  nucleoplasm  centrosome  crossover junction endodeoxyribonuclease activity  regulation of centrosome duplication  metal ion binding  extracellular exosome  resolution of recombination intermediates  resolution of mitotic recombination intermediates  positive regulation of mitotic cell cycle spindle assembly checkpoint  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  DNA binding  endodeoxyribonuclease activity  nucleoplasm  centrosome  crossover junction endodeoxyribonuclease activity  regulation of centrosome duplication  metal ion binding  extracellular exosome  resolution of recombination intermediates  resolution of mitotic recombination intermediates  positive regulation of mitotic cell cycle spindle assembly checkpoint  nucleic acid phosphodiester bond hydrolysis  
NDEx NetworkGEN1
Atlas of Cancer Signalling NetworkGEN1
Wikipedia pathwaysGEN1
Orthology - Evolution
OrthoDB348654
GeneTree (enSembl)ENSG00000178295
Phylogenetic Trees/Animal Genes : TreeFamGEN1
HOVERGENQ17RS7
HOGENOMQ17RS7
Homologs : HomoloGeneGEN1
Homology/Alignments : Family Browser (UCSC)GEN1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGEN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GEN1
dbVarGEN1
ClinVarGEN1
1000_GenomesGEN1 
Exome Variant ServerGEN1
ExAC (Exome Aggregation Consortium)GEN1 (select the gene name)
Genetic variants : HAPMAP348654
Genomic Variants (DGV)GEN1 [DGVbeta]
DECIPHERGEN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGEN1 
Mutations
ICGC Data PortalGEN1 
TCGA Data PortalGEN1 
Broad Tumor PortalGEN1
OASIS PortalGEN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGEN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGEN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GEN1
DgiDB (Drug Gene Interaction Database)GEN1
DoCM (Curated mutations)GEN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GEN1 (select a term)
intoGenGEN1
Cancer3DGEN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612449   
Orphanet
MedgenGEN1
Genetic Testing Registry GEN1
NextProtQ17RS7 [Medical]
TSGene348654
GENETestsGEN1
Target ValidationGEN1
Huge Navigator GEN1 [HugePedia]
snp3D : Map Gene to Disease348654
BioCentury BCIQGEN1
ClinGenGEN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD348654
Chemical/Pharm GKB GenePA162389359
Clinical trialGEN1
Miscellaneous
canSAR (ICR)GEN1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGEN1
EVEXGEN1
GoPubMedGEN1
iHOPGEN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:01:57 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.