GET3 (guided entry of tail-anchored proteins factor 3, ATPase)

2019-05-01  

Identity

HGNC
GET3
LOCATION
19p13.13
LOCUSID
439
ALIAS
ARSA-I,ARSA1,ASNA-I,ASNA1,TRC40

Other Information

Locus ID:

NCBI: 439
MIM: 601913
HGNC: 752
Ensembl: ENSG00000198356

Variants:

dbSNP: 439
ClinVar: 439
TCGA: ENSG00000198356
COSMIC: GET3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198356ENST00000357332O43681
ENSG00000198356ENST00000591090O43681

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

References

Pubmed IDYearTitleCitations
173828832007Identification of a targeting factor for posttranslational membrane protein insertion into the ER.175
172895752007ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.57
214447552011WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.48
186674362008A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum.47
230412872012Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.43
234606772013Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway.33
203750642010Asna1/TRC40-mediated membrane insertion of tail-anchored proteins.30
225056072012TRC40 can deliver short secretory proteins to the Sec61 translocon.27
274581902016Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.20
212969832011EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP.15

Citation

Dessen P

GET3 (guided entry of tail-anchored proteins factor 3, ATPase)

Atlas Genet Cytogenet Oncol Haematol. 2019-05-01

Online version: http://atlasgeneticsoncology.org/gene/57981/get3