Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GFER (growth factor, augmenter of liver regeneration)

Identity

Alias_namesgrowth factor
Alias_symbol (synonym)HSS
ERV1
ALR
HERV1
HPO1
HPO2
Other aliasHPO
HGNC (Hugo) GFER
LocusID (NCBI) 2671
Atlas_Id 46576
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1984149 and ends at 1987749 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZNF704 (8q21.13) / GFER (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;16)(q21;p13) ZNF704/GFER

External links

Nomenclature
HGNC (Hugo)GFER   4236
Cards
Entrez_Gene (NCBI)GFER  2671  growth factor, augmenter of liver regeneration
AliasesALR; ERV1; HERV1; HPO; 
HPO1; HPO2; HSS
GeneCards (Weizmann)GFER
Ensembl hg19 (Hinxton)ENSG00000127554 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127554 [Gene_View]  ENSG00000127554 [Sequence]  chr16:1984149-1987749 [Contig_View]  GFER [Vega]
ICGC DataPortalENSG00000127554
TCGA cBioPortalGFER
AceView (NCBI)GFER
Genatlas (Paris)GFER
WikiGenes2671
SOURCE (Princeton)GFER
Genetics Home Reference (NIH)GFER
Genomic and cartography
GoldenPath hg38 (UCSC)GFER  -     chr16:1984149-1987749 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GFER  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblGFER - 16p13.3 [CytoView hg19]  GFER - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIGFER [Mapview hg19]  GFER [Mapview hg38]
OMIM600924   613076   
Gene and transcription
Genbank (Entrez)AF124603 AF124604 AF208342 AF306863 AY550027
RefSeq transcript (Entrez)NM_005262
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GFER
Cluster EST : UnigeneHs.27184 [ NCBI ]
CGAP (NCI)Hs.27184
Alternative Splicing GalleryENSG00000127554
Gene ExpressionGFER [ NCBI-GEO ]   GFER [ EBI - ARRAY_EXPRESS ]   GFER [ SEEK ]   GFER [ MEM ]
Gene Expression Viewer (FireBrowse)GFER [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2671
GTEX Portal (Tissue expression)GFER
Human Protein AtlasENSG00000127554-GFER [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55789   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55789  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55789
Splice isoforms : SwissVarP55789
Catalytic activity : Enzyme1.8.3.2 [ Enzyme-Expasy ]   1.8.3.21.8.3.2 [ IntEnz-EBI ]   1.8.3.2 [ BRENDA ]   1.8.3.2 [ KEGG ]   
PhosPhoSitePlusP55789
Domaine pattern : Prosite (Expaxy)ERV_ALR (PS51324)   
Domains : Interpro (EBI)ERV/ALR_sulphydryl_oxid_sf    ERV/ALR_sulphydryl_oxidase   
Domain families : Pfam (Sanger)Evr1_Alr (PF04777)   
Domain families : Pfam (NCBI)pfam04777   
Conserved Domain (NCBI)GFER
DMDM Disease mutations2671
Blocks (Seattle)GFER
PDB (SRS)3MBG    3O55    3TK0    3U2L    3U2M    3U5S    4LDK   
PDB (PDBSum)3MBG    3O55    3TK0    3U2L    3U2M    3U5S    4LDK   
PDB (IMB)3MBG    3O55    3TK0    3U2L    3U2M    3U5S    4LDK   
PDB (RSDB)3MBG    3O55    3TK0    3U2L    3U2M    3U5S    4LDK   
Structural Biology KnowledgeBase3MBG    3O55    3TK0    3U2L    3U2M    3U5S    4LDK   
SCOP (Structural Classification of Proteins)3MBG    3O55    3TK0    3U2L    3U2M    3U5S    4LDK   
CATH (Classification of proteins structures)3MBG    3O55    3TK0    3U2L    3U2M    3U5S    4LDK   
SuperfamilyP55789
Human Protein Atlas [tissue]ENSG00000127554-GFER [tissue]
Peptide AtlasP55789
HPRD02954
IPIIPI00902969   IPI00385905   IPI00472356   IPI00645877   
Protein Interaction databases
DIP (DOE-UCLA)P55789
IntAct (EBI)P55789
FunCoupENSG00000127554
BioGRIDGFER
STRING (EMBL)GFER
ZODIACGFER
Ontologies - Pathways
QuickGOP55789
Ontology : AmiGOprotein binding  extracellular region  mitochondrion  mitochondrion  mitochondrial intermembrane space  cytosol  growth factor activity  regulation of signaling receptor activity  protein disulfide oxidoreductase activity  protein disulfide oxidoreductase activity  flavin-linked sulfhydryl oxidase activity  flavin adenine dinucleotide binding  flavin adenine dinucleotide binding  oxidation-reduction process  
Ontology : EGO-EBIprotein binding  extracellular region  mitochondrion  mitochondrion  mitochondrial intermembrane space  cytosol  growth factor activity  regulation of signaling receptor activity  protein disulfide oxidoreductase activity  protein disulfide oxidoreductase activity  flavin-linked sulfhydryl oxidase activity  flavin adenine dinucleotide binding  flavin adenine dinucleotide binding  oxidation-reduction process  
NDEx NetworkGFER
Atlas of Cancer Signalling NetworkGFER
Wikipedia pathwaysGFER
Orthology - Evolution
OrthoDB2671
GeneTree (enSembl)ENSG00000127554
Phylogenetic Trees/Animal Genes : TreeFamGFER
HOVERGENP55789
HOGENOMP55789
Homologs : HomoloGeneGFER
Homology/Alignments : Family Browser (UCSC)GFER
Gene fusions - Rearrangements
Fusion : MitelmanZNF704/GFER [8q21.13/16p13.3]  [t(8;16)(q21;p13)]  
Fusion : QuiverGFER
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGFER [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GFER
dbVarGFER
ClinVarGFER
1000_GenomesGFER 
Exome Variant ServerGFER
ExAC (Exome Aggregation Consortium)ENSG00000127554
GNOMAD BrowserENSG00000127554
Varsome BrowserGFER
Genetic variants : HAPMAP2671
Genomic Variants (DGV)GFER [DGVbeta]
DECIPHERGFER [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGFER 
Mutations
ICGC Data PortalGFER 
TCGA Data PortalGFER 
Broad Tumor PortalGFER
OASIS PortalGFER [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGFER  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGFER
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GFER
DgiDB (Drug Gene Interaction Database)GFER
DoCM (Curated mutations)GFER (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GFER (select a term)
intoGenGFER
Cancer3DGFER(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600924    613076   
Orphanet21965   
DisGeNETGFER
MedgenGFER
Genetic Testing Registry GFER
NextProtP55789 [Medical]
TSGene2671
GENETestsGFER
Target ValidationGFER
Huge Navigator GFER [HugePedia]
snp3D : Map Gene to Disease2671
BioCentury BCIQGFER
ClinGenGFER
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2671
Chemical/Pharm GKB GenePA28648
Clinical trialGFER
Miscellaneous
canSAR (ICR)GFER (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGFER
EVEXGFER
GoPubMedGFER
iHOPGFER
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:08:17 CET 2018
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