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GFRA1 (GDNF family receptor alpha 1)

Identity

Alias (NCBI)GDNFR
GDNFRA
GFR-ALPHA-1
GFRalpha-1
RET1L
RETL1
TRNR1
HGNC (Hugo) GFRA1
HGNC Alias symbRETL1
GDNFR
GFR-ALPHA-1
RET1L
TRNR1
HGNC Previous nameGDNFRA
LocusID (NCBI) 2674
Atlas_Id 40708
Location 10q25.3  [Link to chromosome band 10q25]
Location_base_pair Starts at 116056931 and ends at 116272225 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GFRA1 (10q25.3) / DGKB (7p21.2)GFRA1 (10q25.3) / PLA2G2A (1p36.13)GFRA1 (10q25.3) / RNPS1 (16p13.3)
GFRA1 10q25.3 / DGKB 7p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GFRA1   4243
Cards
Entrez_Gene (NCBI)GFRA1    GDNF family receptor alpha 1
AliasesGDNFR; GDNFRA; GFR-ALPHA-1; GFRalpha-1; 
RET1L; RETL1; TRNR1
GeneCards (Weizmann)GFRA1
Ensembl hg19 (Hinxton)ENSG00000151892 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151892 [Gene_View]  ENSG00000151892 [Sequence]  chr10:116056931-116272225 [Contig_View]  GFRA1 [Vega]
ICGC DataPortalENSG00000151892
TCGA cBioPortalGFRA1
AceView (NCBI)GFRA1
Genatlas (Paris)GFRA1
SOURCE (Princeton)GFRA1
Genetics Home Reference (NIH)GFRA1
Genomic and cartography
GoldenPath hg38 (UCSC)GFRA1  -     chr10:116056931-116272225 -  10q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GFRA1  -     10q25.3   [Description]    (hg19-Feb_2009)
GoldenPathGFRA1 - 10q25.3 [CytoView hg19]  GFRA1 - 10q25.3 [CytoView hg38]
ImmunoBaseENSG00000151892
Genome Data Viewer NCBIGFRA1 [Mapview hg19]  
OMIM601496   
Gene and transcription
Genbank (Entrez)AB025561 AB025562 AF038421 AF042080 AK001423
RefSeq transcript (Entrez)NM_001145453 NM_001348096 NM_001348098 NM_001348099 NM_001382556 NM_001382557 NM_001382558 NM_001382559 NM_001382560 NM_001382561 NM_005264 NM_145793
Consensus coding sequences : CCDS (NCBI)GFRA1
Gene ExpressionGFRA1 [ NCBI-GEO ]   GFRA1 [ EBI - ARRAY_EXPRESS ]   GFRA1 [ SEEK ]   GFRA1 [ MEM ]
Gene Expression Viewer (FireBrowse)GFRA1 [ Firebrowse - Broad ]
GenevisibleExpression of GFRA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2674
GTEX Portal (Tissue expression)GFRA1
Human Protein AtlasENSG00000151892-GFRA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56159   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56159  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56159
PhosPhoSitePlusP56159
Domains : Interpro (EBI)GDNF/GAS1    GDNF_alpha    GDNF_rcpt    GDNF_rcpt_A1    Glial_neurotroph_fac_rcpt_a1/2   
Domain families : Pfam (Sanger)GDNF (PF02351)   
Domain families : Pfam (NCBI)pfam02351   
Domain families : Smart (EMBL)GDNF (SM00907)  
Conserved Domain (NCBI)GFRA1
PDB (RSDB)6Q2N   
PDB Europe6Q2N   
PDB (PDBSum)6Q2N   
PDB (IMB)6Q2N   
Structural Biology KnowledgeBase6Q2N   
SCOP (Structural Classification of Proteins)6Q2N   
CATH (Classification of proteins structures)6Q2N   
SuperfamilyP56159
AlphaFold pdb e-kbP56159   
Human Protein Atlas [tissue]ENSG00000151892-GFRA1 [tissue]
HPRD03291
Protein Interaction databases
DIP (DOE-UCLA)P56159
IntAct (EBI)P56159
BioGRIDGFRA1
STRING (EMBL)GFRA1
ZODIACGFRA1
Ontologies - Pathways
QuickGOP56159
Ontology : AmiGOMAPK cascade  signaling receptor binding  multivesicular body  Golgi apparatus  plasma membrane  cell surface receptor signaling pathway  nervous system development  axon guidance  external side of plasma membrane  glial cell-derived neurotrophic factor receptor activity  extrinsic component of membrane  anchored component of membrane  glial cell-derived neurotrophic factor receptor signaling pathway  signaling receptor activity  receptor complex  extracellular exosome  
Ontology : EGO-EBIMAPK cascade  signaling receptor binding  multivesicular body  Golgi apparatus  plasma membrane  cell surface receptor signaling pathway  nervous system development  axon guidance  external side of plasma membrane  glial cell-derived neurotrophic factor receptor activity  extrinsic component of membrane  anchored component of membrane  glial cell-derived neurotrophic factor receptor signaling pathway  signaling receptor activity  receptor complex  extracellular exosome  
NDEx NetworkGFRA1
Atlas of Cancer Signalling NetworkGFRA1
Wikipedia pathwaysGFRA1
Orthology - Evolution
OrthoDB2674
GeneTree (enSembl)ENSG00000151892
Phylogenetic Trees/Animal Genes : TreeFamGFRA1
Homologs : HomoloGeneGFRA1
Homology/Alignments : Family Browser (UCSC)GFRA1
Gene fusions - Rearrangements
Fusion : MitelmanGFRA1/DGKB [10q25.3/7p21.2]  
Fusion : QuiverGFRA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGFRA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GFRA1
dbVarGFRA1
ClinVarGFRA1
MonarchGFRA1
1000_GenomesGFRA1 
Exome Variant ServerGFRA1
GNOMAD BrowserENSG00000151892
Varsome BrowserGFRA1
ACMGGFRA1 variants
VarityP56159
Genomic Variants (DGV)GFRA1 [DGVbeta]
DECIPHERGFRA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGFRA1 
Mutations
ICGC Data PortalGFRA1 
TCGA Data PortalGFRA1 
Broad Tumor PortalGFRA1
OASIS PortalGFRA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGFRA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGFRA1
Mutations and Diseases : HGMDGFRA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGFRA1
DgiDB (Drug Gene Interaction Database)GFRA1
DoCM (Curated mutations)GFRA1
CIViC (Clinical Interpretations of Variants in Cancer)GFRA1
Cancer3DGFRA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601496   
Orphanet
DisGeNETGFRA1
MedgenGFRA1
Genetic Testing Registry GFRA1
NextProtP56159 [Medical]
GENETestsGFRA1
Target ValidationGFRA1
Huge Navigator GFRA1 [HugePedia]
ClinGenGFRA1
Clinical trials, drugs, therapy
MyCancerGenomeGFRA1
Protein Interactions : CTDGFRA1
Pharm GKB GenePA28653
PharosP56159
Clinical trialGFRA1
Miscellaneous
canSAR (ICR)GFRA1
HarmonizomeGFRA1
DataMed IndexGFRA1
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGFRA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:10:39 CEST 2021

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