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GFRA2 (GDNF family receptor alpha 2)

Identity

Alias_symbol (synonym)RETL2
GDNFRB
NTNRA
TRNR2
Other aliasNRTNR-ALPHA
HGNC (Hugo) GFRA2
LocusID (NCBI) 2675
Atlas_Id 53862
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 21692018 and ends at 21788834 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GFRA2   4244
Cards
Entrez_Gene (NCBI)GFRA2  2675  GDNF family receptor alpha 2
AliasesGDNFRB; NRTNR-ALPHA; NTNRA; RETL2; 
TRNR2
GeneCards (Weizmann)GFRA2
Ensembl hg19 (Hinxton)ENSG00000168546 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168546 [Gene_View]  chr8:21692018-21788834 [Contig_View]  GFRA2 [Vega]
ICGC DataPortalENSG00000168546
TCGA cBioPortalGFRA2
AceView (NCBI)GFRA2
Genatlas (Paris)GFRA2
WikiGenes2675
SOURCE (Princeton)GFRA2
Genetics Home Reference (NIH)GFRA2
Genomic and cartography
GoldenPath hg38 (UCSC)GFRA2  -     chr8:21692018-21788834 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GFRA2  -     8p21.3   [Description]    (hg19-Feb_2009)
EnsemblGFRA2 - 8p21.3 [CytoView hg19]  GFRA2 - 8p21.3 [CytoView hg38]
Mapping of homologs : NCBIGFRA2 [Mapview hg19]  GFRA2 [Mapview hg38]
OMIM601956   
Gene and transcription
Genbank (Entrez)AF002700 AK299623 AY326396 AY941828 BC041688
RefSeq transcript (Entrez)NM_001165038 NM_001165039 NM_001495
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GFRA2
Cluster EST : UnigeneHs.441202 [ NCBI ]
CGAP (NCI)Hs.441202
Alternative Splicing GalleryENSG00000168546
Gene ExpressionGFRA2 [ NCBI-GEO ]   GFRA2 [ EBI - ARRAY_EXPRESS ]   GFRA2 [ SEEK ]   GFRA2 [ MEM ]
Gene Expression Viewer (FireBrowse)GFRA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2675
GTEX Portal (Tissue expression)GFRA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00451   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00451  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00451
Splice isoforms : SwissVarO00451
PhosPhoSitePlusO00451
Domains : Interpro (EBI)GDNF/GAS1    GDNF_rcpt    GDNF_rcpt_a2    Glial_neurotroph_fac_rcpt_a1/2   
Domain families : Pfam (Sanger)GDNF (PF02351)   
Domain families : Pfam (NCBI)pfam02351   
Domain families : Smart (EMBL)GDNF (SM00907)  
Conserved Domain (NCBI)GFRA2
DMDM Disease mutations2675
Blocks (Seattle)GFRA2
SuperfamilyO00451
Human Protein AtlasENSG00000168546
Peptide AtlasO00451
HPRD11801
IPIIPI00011732   IPI00398301   IPI00973296   IPI00947379   IPI00978996   IPI00976898   IPI00978314   
Protein Interaction databases
DIP (DOE-UCLA)O00451
IntAct (EBI)O00451
FunCoupENSG00000168546
BioGRIDGFRA2
STRING (EMBL)GFRA2
ZODIACGFRA2
Ontologies - Pathways
QuickGOO00451
Ontology : AmiGOMAPK cascade  Ras guanyl-nucleotide exchange factor activity  intracellular  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  glial cell-derived neurotrophic factor receptor activity  extrinsic component of membrane  anchored component of membrane  negative regulation of protein autophosphorylation  glial cell-derived neurotrophic factor receptor signaling pathway  positive regulation of GTPase activity  
Ontology : EGO-EBIMAPK cascade  Ras guanyl-nucleotide exchange factor activity  intracellular  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  axon guidance  glial cell-derived neurotrophic factor receptor activity  extrinsic component of membrane  anchored component of membrane  negative regulation of protein autophosphorylation  glial cell-derived neurotrophic factor receptor signaling pathway  positive regulation of GTPase activity  
NDEx NetworkGFRA2
Atlas of Cancer Signalling NetworkGFRA2
Wikipedia pathwaysGFRA2
Orthology - Evolution
OrthoDB2675
GeneTree (enSembl)ENSG00000168546
Phylogenetic Trees/Animal Genes : TreeFamGFRA2
HOVERGENO00451
HOGENOMO00451
Homologs : HomoloGeneGFRA2
Homology/Alignments : Family Browser (UCSC)GFRA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGFRA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GFRA2
dbVarGFRA2
ClinVarGFRA2
1000_GenomesGFRA2 
Exome Variant ServerGFRA2
ExAC (Exome Aggregation Consortium)GFRA2 (select the gene name)
Genetic variants : HAPMAP2675
Genomic Variants (DGV)GFRA2 [DGVbeta]
DECIPHERGFRA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGFRA2 
Mutations
ICGC Data PortalGFRA2 
TCGA Data PortalGFRA2 
Broad Tumor PortalGFRA2
OASIS PortalGFRA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGFRA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGFRA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GFRA2
DgiDB (Drug Gene Interaction Database)GFRA2
DoCM (Curated mutations)GFRA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GFRA2 (select a term)
intoGenGFRA2
Cancer3DGFRA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601956   
Orphanet
MedgenGFRA2
Genetic Testing Registry GFRA2
NextProtO00451 [Medical]
TSGene2675
GENETestsGFRA2
Target ValidationGFRA2
Huge Navigator GFRA2 [HugePedia]
snp3D : Map Gene to Disease2675
BioCentury BCIQGFRA2
ClinGenGFRA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2675
Chemical/Pharm GKB GenePA28654
Clinical trialGFRA2
Miscellaneous
canSAR (ICR)GFRA2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGFRA2
EVEXGFRA2
GoPubMedGFRA2
iHOPGFRA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:54:13 CEST 2017

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