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GFRA2 (GDNF family receptor alpha 2)

Identity

Alias (NCBI)GDNFRB
NRTNR-ALPHA
NTNRA
RETL2
TRNR2
HGNC (Hugo) GFRA2
HGNC Alias symbRETL2
GDNFRB
NTNRA
TRNR2
LocusID (NCBI) 2675
Atlas_Id 53862
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 21690398 and ends at 21788875 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GFRA2   4244
Cards
Entrez_Gene (NCBI)GFRA2    GDNF family receptor alpha 2
AliasesGDNFRB; NRTNR-ALPHA; NTNRA; RETL2; 
TRNR2
GeneCards (Weizmann)GFRA2
Ensembl hg19 (Hinxton)ENSG00000168546 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168546 [Gene_View]  ENSG00000168546 [Sequence]  chr8:21690398-21788875 [Contig_View]  GFRA2 [Vega]
ICGC DataPortalENSG00000168546
TCGA cBioPortalGFRA2
AceView (NCBI)GFRA2
Genatlas (Paris)GFRA2
SOURCE (Princeton)GFRA2
Genetics Home Reference (NIH)GFRA2
Genomic and cartography
GoldenPath hg38 (UCSC)GFRA2  -     chr8:21690398-21788875 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GFRA2  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathGFRA2 - 8p21.3 [CytoView hg19]  GFRA2 - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000168546
Genome Data Viewer NCBIGFRA2 [Mapview hg19]  
OMIM601956   
Gene and transcription
Genbank (Entrez)AF002700 AK299623 AY326396 AY941828 BC041688
RefSeq transcript (Entrez)NM_001165038 NM_001165039 NM_001495
Consensus coding sequences : CCDS (NCBI)GFRA2
Gene ExpressionGFRA2 [ NCBI-GEO ]   GFRA2 [ EBI - ARRAY_EXPRESS ]   GFRA2 [ SEEK ]   GFRA2 [ MEM ]
Gene Expression Viewer (FireBrowse)GFRA2 [ Firebrowse - Broad ]
GenevisibleExpression of GFRA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2675
GTEX Portal (Tissue expression)GFRA2
Human Protein AtlasENSG00000168546-GFRA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00451   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00451  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00451
PhosPhoSitePlusO00451
Domains : Interpro (EBI)GDNF/GAS1    GDNF_alpha    GDNF_rcpt    GDNF_rcpt_a2    Glial_neurotroph_fac_rcpt_a1/2   
Domain families : Pfam (Sanger)GDNF (PF02351)   
Domain families : Pfam (NCBI)pfam02351   
Domain families : Smart (EMBL)GDNF (SM00907)  
Conserved Domain (NCBI)GFRA2
PDB (RSDB)5MR4    5MR5    6GL7    6Q2O    6Q2R   
PDB Europe5MR4    5MR5    6GL7    6Q2O    6Q2R   
PDB (PDBSum)5MR4    5MR5    6GL7    6Q2O    6Q2R   
PDB (IMB)5MR4    5MR5    6GL7    6Q2O    6Q2R   
Structural Biology KnowledgeBase5MR4    5MR5    6GL7    6Q2O    6Q2R   
SCOP (Structural Classification of Proteins)5MR4    5MR5    6GL7    6Q2O    6Q2R   
CATH (Classification of proteins structures)5MR4    5MR5    6GL7    6Q2O    6Q2R   
SuperfamilyO00451
AlphaFold pdb e-kbO00451   
Human Protein Atlas [tissue]ENSG00000168546-GFRA2 [tissue]
HPRD11801
Protein Interaction databases
DIP (DOE-UCLA)O00451
IntAct (EBI)O00451
BioGRIDGFRA2
STRING (EMBL)GFRA2
ZODIACGFRA2
Ontologies - Pathways
QuickGOO00451
Ontology : AmiGOMAPK cascade  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  nervous system development  axon guidance  external side of plasma membrane  glial cell-derived neurotrophic factor receptor activity  extrinsic component of membrane  anchored component of membrane  negative regulation of protein autophosphorylation  glial cell-derived neurotrophic factor receptor signaling pathway  signaling receptor activity  receptor complex  
Ontology : EGO-EBIMAPK cascade  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  nervous system development  axon guidance  external side of plasma membrane  glial cell-derived neurotrophic factor receptor activity  extrinsic component of membrane  anchored component of membrane  negative regulation of protein autophosphorylation  glial cell-derived neurotrophic factor receptor signaling pathway  signaling receptor activity  receptor complex  
NDEx NetworkGFRA2
Atlas of Cancer Signalling NetworkGFRA2
Wikipedia pathwaysGFRA2
Orthology - Evolution
OrthoDB2675
GeneTree (enSembl)ENSG00000168546
Phylogenetic Trees/Animal Genes : TreeFamGFRA2
Homologs : HomoloGeneGFRA2
Homology/Alignments : Family Browser (UCSC)GFRA2
Gene fusions - Rearrangements
Fusion : QuiverGFRA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGFRA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GFRA2
dbVarGFRA2
ClinVarGFRA2
MonarchGFRA2
1000_GenomesGFRA2 
Exome Variant ServerGFRA2
GNOMAD BrowserENSG00000168546
Varsome BrowserGFRA2
ACMGGFRA2 variants
VarityO00451
Genomic Variants (DGV)GFRA2 [DGVbeta]
DECIPHERGFRA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGFRA2 
Mutations
ICGC Data PortalGFRA2 
TCGA Data PortalGFRA2 
Broad Tumor PortalGFRA2
OASIS PortalGFRA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGFRA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGFRA2
Mutations and Diseases : HGMDGFRA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGFRA2
DgiDB (Drug Gene Interaction Database)GFRA2
DoCM (Curated mutations)GFRA2
CIViC (Clinical Interpretations of Variants in Cancer)GFRA2
Cancer3DGFRA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601956   
Orphanet
DisGeNETGFRA2
MedgenGFRA2
Genetic Testing Registry GFRA2
NextProtO00451 [Medical]
GENETestsGFRA2
Target ValidationGFRA2
Huge Navigator GFRA2 [HugePedia]
ClinGenGFRA2
Clinical trials, drugs, therapy
MyCancerGenomeGFRA2
Protein Interactions : CTDGFRA2
Pharm GKB GenePA28654
PharosO00451
Clinical trialGFRA2
Miscellaneous
canSAR (ICR)GFRA2
HarmonizomeGFRA2
DataMed IndexGFRA2
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGFRA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:10:39 CEST 2021

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