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GFRAL (GDNF family receptor alpha like)

Identity

Alias (NCBI)C6orf144
GRAL
UNQ9356
bA360D14.1
HGNC (Hugo) GFRAL
HGNC Alias symbGRAL
UNQ9356
bA360D14.1
HGNC Previous nameC6orf144
HGNC Previous namechromosome 6 open reading frame 144
LocusID (NCBI) 389400
Atlas_Id 63761
Location 6p12.1  [Link to chromosome band 6p12]
Location_base_pair Starts at 55327469 and ends at 55402493 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC138 (2q12.3) / GFRAL (6p12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GFRAL   32789
Cards
Entrez_Gene (NCBI)GFRAL    GDNF family receptor alpha like
AliasesC6orf144; GRAL; UNQ9356; bA360D14.1
GeneCards (Weizmann)GFRAL
Ensembl hg19 (Hinxton)ENSG00000187871 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187871 [Gene_View]  ENSG00000187871 [Sequence]  chr6:55327469-55402493 [Contig_View]  GFRAL [Vega]
ICGC DataPortalENSG00000187871
TCGA cBioPortalGFRAL
AceView (NCBI)GFRAL
Genatlas (Paris)GFRAL
SOURCE (Princeton)GFRAL
Genetics Home Reference (NIH)GFRAL
Genomic and cartography
GoldenPath hg38 (UCSC)GFRAL  -     chr6:55327469-55402493 +  6p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GFRAL  -     6p12.1   [Description]    (hg19-Feb_2009)
GoldenPathGFRAL - 6p12.1 [CytoView hg19]  GFRAL - 6p12.1 [CytoView hg38]
ImmunoBaseENSG00000187871
Genome Data Viewer NCBIGFRAL [Mapview hg19]  
OMIM617837   
Gene and transcription
Genbank (Entrez)AY358198
RefSeq transcript (Entrez)NM_207410
Consensus coding sequences : CCDS (NCBI)GFRAL
Gene ExpressionGFRAL [ NCBI-GEO ]   GFRAL [ EBI - ARRAY_EXPRESS ]   GFRAL [ SEEK ]   GFRAL [ MEM ]
Gene Expression Viewer (FireBrowse)GFRAL [ Firebrowse - Broad ]
GenevisibleExpression of GFRAL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)389400
GTEX Portal (Tissue expression)GFRAL
Human Protein AtlasENSG00000187871-GFRAL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXV0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXV0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXV0
PhosPhoSitePlusQ6UXV0
Domains : Interpro (EBI)GDNF/GAS1    GDNF_alpha    GDNF_rcpt   
Domain families : Pfam (Sanger)GDNF (PF02351)   
Domain families : Pfam (NCBI)pfam02351   
Domain families : Smart (EMBL)GDNF (SM00907)  
Conserved Domain (NCBI)GFRAL
PDB (RSDB)5VZ4    6Q2J    6WMW   
PDB Europe5VZ4    6Q2J    6WMW   
PDB (PDBSum)5VZ4    6Q2J    6WMW   
PDB (IMB)5VZ4    6Q2J    6WMW   
Structural Biology KnowledgeBase5VZ4    6Q2J    6WMW   
SCOP (Structural Classification of Proteins)5VZ4    6Q2J    6WMW   
CATH (Classification of proteins structures)5VZ4    6Q2J    6WMW   
SuperfamilyQ6UXV0
AlphaFold pdb e-kbQ6UXV0   
Human Protein Atlas [tissue]ENSG00000187871-GFRAL [tissue]
HPRD15622
Protein Interaction databases
DIP (DOE-UCLA)Q6UXV0
IntAct (EBI)Q6UXV0
BioGRIDGFRAL
STRING (EMBL)GFRAL
ZODIACGFRAL
Ontologies - Pathways
QuickGOQ6UXV0
Ontology : AmiGOactivation of MAPK activity  reduction of food intake in response to dietary excess  protein binding  nervous system development  external side of plasma membrane  external side of plasma membrane  integral component of membrane  glial cell-derived neurotrophic factor receptor activity  receptor tyrosine kinase binding  stress-activated protein kinase signaling cascade  glial cell-derived neurotrophic factor receptor signaling pathway  signaling receptor activity  receptor complex  positive regulation of MAPK cascade  negative regulation of neuron apoptotic process  positive regulation of protein kinase B signaling  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIactivation of MAPK activity  reduction of food intake in response to dietary excess  protein binding  nervous system development  external side of plasma membrane  external side of plasma membrane  integral component of membrane  glial cell-derived neurotrophic factor receptor activity  receptor tyrosine kinase binding  stress-activated protein kinase signaling cascade  glial cell-derived neurotrophic factor receptor signaling pathway  signaling receptor activity  receptor complex  positive regulation of MAPK cascade  negative regulation of neuron apoptotic process  positive regulation of protein kinase B signaling  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
NDEx NetworkGFRAL
Atlas of Cancer Signalling NetworkGFRAL
Wikipedia pathwaysGFRAL
Orthology - Evolution
OrthoDB389400
GeneTree (enSembl)ENSG00000187871
Phylogenetic Trees/Animal Genes : TreeFamGFRAL
Homologs : HomoloGeneGFRAL
Homology/Alignments : Family Browser (UCSC)GFRAL
Gene fusions - Rearrangements
Fusion : QuiverGFRAL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGFRAL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GFRAL
dbVarGFRAL
ClinVarGFRAL
MonarchGFRAL
1000_GenomesGFRAL 
Exome Variant ServerGFRAL
GNOMAD BrowserENSG00000187871
Varsome BrowserGFRAL
ACMGGFRAL variants
VarityQ6UXV0
Genomic Variants (DGV)GFRAL [DGVbeta]
DECIPHERGFRAL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGFRAL 
Mutations
ICGC Data PortalGFRAL 
TCGA Data PortalGFRAL 
Broad Tumor PortalGFRAL
OASIS PortalGFRAL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGFRAL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGFRAL
Mutations and Diseases : HGMDGFRAL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGFRAL
DgiDB (Drug Gene Interaction Database)GFRAL
DoCM (Curated mutations)GFRAL
CIViC (Clinical Interpretations of Variants in Cancer)GFRAL
Cancer3DGFRAL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617837   
Orphanet
DisGeNETGFRAL
MedgenGFRAL
Genetic Testing Registry GFRAL
NextProtQ6UXV0 [Medical]
GENETestsGFRAL
Target ValidationGFRAL
Huge Navigator GFRAL [HugePedia]
ClinGenGFRAL
Clinical trials, drugs, therapy
MyCancerGenomeGFRAL
Protein Interactions : CTDGFRAL
Pharm GKB GenePA145008357
PharosQ6UXV0
Clinical trialGFRAL
Miscellaneous
canSAR (ICR)GFRAL
HarmonizomeGFRAL
DataMed IndexGFRAL
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGFRAL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:51:23 CEST 2021

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