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GFUS (GDP-L-fucose synthase)

Identity

Alias (NCBI)FX
P35B
SDR4E1
TSTA3
HGNC (Hugo) GFUS
HGNC Alias symbFX
P35B
SDR4E1
HGNC Alias nameshort chain dehydrogenase/reductase family 4E, member 1
HGNC Previous nameTSTA3
HGNC Previous nametissue specific transplantation antigen P35B
LocusID (NCBI) 7264
Atlas_Id 52892
Location 8q24.3  [Link to chromosome band 8q24]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EEF1D 8q24.3 / TSTA3 8q24.3
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)GFUS   12390
Cards
Entrez_Gene (NCBI)GFUS    GDP-L-fucose synthase
AliasesFX; P35B; SDR4E1; TSTA3
GeneCards (Weizmann)GFUS
Ensembl hg19 (Hinxton)ENSG00000104522 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104522 [Gene_View]  ENSG00000104522 [Sequence]  - [Contig_View]  GFUS [Vega]
ICGC DataPortalENSG00000104522
TCGA cBioPortalGFUS
AceView (NCBI)GFUS
Genatlas (Paris)GFUS
SOURCE (Princeton)GFUS
Genetics Home Reference (NIH)GFUS
Genomic and cartography
GoldenPath hg38 (UCSC)GFUS  -  
GoldenPath hg19 (UCSC)GFUS  -  
GoldenPathGFUS - [CytoView hg19]  GFUS - [CytoView hg38]
ImmunoBaseENSG00000104522
Genome Data Viewer NCBIGFUS [Mapview hg19]  
OMIM137020   
Gene and transcription
Genbank (Entrez)AK096752 AK303125 AK313560 BC001941 BC093061
RefSeq transcript (Entrez)NM_001317783 NM_003313
Consensus coding sequences : CCDS (NCBI)GFUS
Gene ExpressionGFUS [ NCBI-GEO ]   GFUS [ EBI - ARRAY_EXPRESS ]   GFUS [ SEEK ]   GFUS [ MEM ]
Gene Expression Viewer (FireBrowse)GFUS [ Firebrowse - Broad ]
GenevisibleExpression of GFUS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7264
GTEX Portal (Tissue expression)GFUS
Human Protein AtlasENSG00000104522-GFUS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13630   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13630  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13630
PhosPhoSitePlusQ13630
Domains : Interpro (EBI)Epimerase_deHydtase    GDP_fucose/colitose_synth    NAD(P)-bd_dom_sf   
Domain families : Pfam (Sanger)Epimerase (PF01370)   
Domain families : Pfam (NCBI)pfam01370   
Conserved Domain (NCBI)GFUS
PDB (RSDB)4B8W    4B8Z    4BKP    4BL5    4E5Y   
PDB Europe4B8W    4B8Z    4BKP    4BL5    4E5Y   
PDB (PDBSum)4B8W    4B8Z    4BKP    4BL5    4E5Y   
PDB (IMB)4B8W    4B8Z    4BKP    4BL5    4E5Y   
Structural Biology KnowledgeBase4B8W    4B8Z    4BKP    4BL5    4E5Y   
SCOP (Structural Classification of Proteins)4B8W    4B8Z    4BKP    4BL5    4E5Y   
CATH (Classification of proteins structures)4B8W    4B8Z    4BKP    4BL5    4E5Y   
SuperfamilyQ13630
AlphaFold pdb e-kbQ13630   
Human Protein Atlas [tissue]ENSG00000104522-GFUS [tissue]
HPRD00654
Protein Interaction databases
DIP (DOE-UCLA)Q13630
IntAct (EBI)Q13630
BioGRIDGFUS
STRING (EMBL)GFUS
ZODIACGFUS
Ontologies - Pathways
QuickGOQ13630
Ontology : AmiGOprotein binding  cytosol  leukocyte cell-cell adhesion  electron transfer activity  positive regulation of endothelial cell migration  GDP-mannose metabolic process  electron transport chain  'de novo' GDP-L-fucose biosynthetic process  'de novo' GDP-L-fucose biosynthetic process  'de novo' GDP-L-fucose biosynthetic process  GDP-4-dehydro-D-rhamnose reductase activity  identical protein binding  GDP-mannose 3,5-epimerase activity  GDP-L-fucose synthase activity  GDP-L-fucose synthase activity  extracellular exosome  positive regulation of endothelial cell-matrix adhesion via fibronectin  
Ontology : EGO-EBIprotein binding  cytosol  leukocyte cell-cell adhesion  electron transfer activity  positive regulation of endothelial cell migration  GDP-mannose metabolic process  electron transport chain  'de novo' GDP-L-fucose biosynthetic process  'de novo' GDP-L-fucose biosynthetic process  'de novo' GDP-L-fucose biosynthetic process  GDP-4-dehydro-D-rhamnose reductase activity  identical protein binding  GDP-mannose 3,5-epimerase activity  GDP-L-fucose synthase activity  GDP-L-fucose synthase activity  extracellular exosome  positive regulation of endothelial cell-matrix adhesion via fibronectin  
NDEx NetworkGFUS
Atlas of Cancer Signalling NetworkGFUS
Wikipedia pathwaysGFUS
Orthology - Evolution
OrthoDB7264
GeneTree (enSembl)ENSG00000104522
Phylogenetic Trees/Animal Genes : TreeFamGFUS
Homologs : HomoloGeneGFUS
Homology/Alignments : Family Browser (UCSC)GFUS
Gene fusions - Rearrangements
Fusion : MitelmanEEF1D/TSTA3 [8q24.3/8q24.3]  
Fusion : QuiverGFUS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGFUS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GFUS
dbVarGFUS
ClinVarGFUS
MonarchGFUS
1000_GenomesGFUS 
Exome Variant ServerGFUS
GNOMAD BrowserENSG00000104522
Varsome BrowserGFUS
ACMGGFUS variants
VarityQ13630
Genomic Variants (DGV)GFUS [DGVbeta]
DECIPHERGFUS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGFUS 
Mutations
ICGC Data PortalGFUS 
TCGA Data PortalGFUS 
Broad Tumor PortalGFUS
OASIS PortalGFUS [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGFUS
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGFUS
DgiDB (Drug Gene Interaction Database)GFUS
DoCM (Curated mutations)GFUS
CIViC (Clinical Interpretations of Variants in Cancer)GFUS
Cancer3DGFUS
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137020   
Orphanet
DisGeNETGFUS
MedgenGFUS
Genetic Testing Registry GFUS
NextProtQ13630 [Medical]
GENETestsGFUS
Target ValidationGFUS
Huge Navigator GFUS [HugePedia]
ClinGenGFUS
Clinical trials, drugs, therapy
MyCancerGenomeGFUS
Protein Interactions : CTDGFUS
Pharm GKB GenePA37056
PharosQ13630
Clinical trialGFUS
Miscellaneous
canSAR (ICR)GFUS
HarmonizomeGFUS
DataMed IndexGFUS
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGFUS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:10:40 CEST 2021

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