Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GGCX (gamma-glutamyl carboxylase)

Identity

Alias_symbol (synonym)VKCFD1
Other alias
HGNC (Hugo) GGCX
LocusID (NCBI) 2677
Atlas_Id 63767
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85544720 and ends at 85561534 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GGCX (2p11.2) / GGCX (2p11.2)GGCX (2p11.2) / ZFP91 (11q12.1)ITPRIPL2 (16p12.3) / GGCX (2p11.2)
KCMF1 (2p11.2) / GGCX (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GGCX   4247
LRG (Locus Reference Genomic)LRG_592
Cards
Entrez_Gene (NCBI)GGCX  2677  gamma-glutamyl carboxylase
AliasesVKCFD1
GeneCards (Weizmann)GGCX
Ensembl hg19 (Hinxton)ENSG00000115486 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115486 [Gene_View]  chr2:85544720-85561534 [Contig_View]  GGCX [Vega]
ICGC DataPortalENSG00000115486
TCGA cBioPortalGGCX
AceView (NCBI)GGCX
Genatlas (Paris)GGCX
WikiGenes2677
SOURCE (Princeton)GGCX
Genetics Home Reference (NIH)GGCX
Genomic and cartography
GoldenPath hg38 (UCSC)GGCX  -     chr2:85544720-85561534 -  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GGCX  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblGGCX - 2p11.2 [CytoView hg19]  GGCX - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBIGGCX [Mapview hg19]  GGCX [Mapview hg38]
OMIM137167   277450   610842   
Gene and transcription
Genbank (Entrez)AK054569 AK130139 AK222827 AK225663 AK297397
RefSeq transcript (Entrez)NM_000821 NM_001142269 NM_001311312
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GGCX
Cluster EST : UnigeneHs.77719 [ NCBI ]
CGAP (NCI)Hs.77719
Alternative Splicing GalleryENSG00000115486
Gene ExpressionGGCX [ NCBI-GEO ]   GGCX [ EBI - ARRAY_EXPRESS ]   GGCX [ SEEK ]   GGCX [ MEM ]
Gene Expression Viewer (FireBrowse)GGCX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2677
GTEX Portal (Tissue expression)GGCX
Human Protein AtlasENSG00000115486-GGCX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP38435   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP38435  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP38435
Splice isoforms : SwissVarP38435
PhosPhoSitePlusP38435
Domains : Interpro (EBI)HTTM    RmlC-like_jellyroll    RmlC_Cupin    VKG_COase   
Domain families : Pfam (Sanger)VKG_Carbox (PF05090)   
Domain families : Pfam (NCBI)pfam05090   
Domain families : Smart (EMBL)HTTM (SM00752)  
Conserved Domain (NCBI)GGCX
DMDM Disease mutations2677
Blocks (Seattle)GGCX
SuperfamilyP38435
Human Protein Atlas [tissue]ENSG00000115486-GGCX [tissue]
Peptide AtlasP38435
HPRD00665
IPIIPI00305698   IPI00917475   IPI00916416   IPI00915421   IPI00917788   
Protein Interaction databases
DIP (DOE-UCLA)P38435
IntAct (EBI)P38435
FunCoupENSG00000115486
BioGRIDGGCX
STRING (EMBL)GGCX
ZODIACGGCX
Ontologies - Pathways
QuickGOP38435
Ontology : AmiGOendoplasmic reticulum membrane  cellular protein modification process  blood coagulation  gamma-glutamyl carboxylase activity  membrane  integral component of membrane  peptidyl-glutamic acid carboxylation  
Ontology : EGO-EBIendoplasmic reticulum membrane  cellular protein modification process  blood coagulation  gamma-glutamyl carboxylase activity  membrane  integral component of membrane  peptidyl-glutamic acid carboxylation  
Pathways : KEGGUbiquinone and other terpenoid-quinone biosynthesis   
NDEx NetworkGGCX
Atlas of Cancer Signalling NetworkGGCX
Wikipedia pathwaysGGCX
Orthology - Evolution
OrthoDB2677
GeneTree (enSembl)ENSG00000115486
Phylogenetic Trees/Animal Genes : TreeFamGGCX
HOVERGENP38435
HOGENOMP38435
Homologs : HomoloGeneGGCX
Homology/Alignments : Family Browser (UCSC)GGCX
Gene fusions - Rearrangements
Tumor Fusion PortalGGCX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGGCX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GGCX
dbVarGGCX
ClinVarGGCX
1000_GenomesGGCX 
Exome Variant ServerGGCX
ExAC (Exome Aggregation Consortium)ENSG00000115486
GNOMAD BrowserENSG00000115486
Genetic variants : HAPMAP2677
Genomic Variants (DGV)GGCX [DGVbeta]
DECIPHERGGCX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGGCX 
Mutations
ICGC Data PortalGGCX 
TCGA Data PortalGGCX 
Broad Tumor PortalGGCX
OASIS PortalGGCX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGGCX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGGCX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GGCX
DgiDB (Drug Gene Interaction Database)GGCX
DoCM (Curated mutations)GGCX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GGCX (select a term)
intoGenGGCX
Cancer3DGGCX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137167    277450    610842   
Orphanet23338    12112    13451   
DisGeNETGGCX
MedgenGGCX
Genetic Testing Registry GGCX
NextProtP38435 [Medical]
TSGene2677
GENETestsGGCX
Target ValidationGGCX
Huge Navigator GGCX [HugePedia]
snp3D : Map Gene to Disease2677
BioCentury BCIQGGCX
ClinGenGGCX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2677
Chemical/Pharm GKB GenePA28660
Clinical trialGGCX
Miscellaneous
canSAR (ICR)GGCX (select the gene name)
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGGCX
EVEXGGCX
GoPubMedGGCX
iHOPGGCX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:04:36 CET 2017

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