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GGTLC2 (gamma-glutamyltransferase light chain 2)

Identity

Alias_namesGGTL4
gamma-glutamyltransferase-like 4
Other alias
HGNC (Hugo) GGTLC2
LocusID (NCBI) 91227
Atlas_Id 63776
Location 22q11.22  [Link to chromosome band 22q11]
Location_base_pair Starts at 22644620 and ends at 22647898 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GGTLC2   18596
Cards
Entrez_Gene (NCBI)GGTLC2  91227  gamma-glutamyltransferase light chain 2
AliasesGGTL4
GeneCards (Weizmann)GGTLC2
Ensembl hg19 (Hinxton)ENSG00000100121 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100121 [Gene_View]  chr22:22644620-22647898 [Contig_View]  GGTLC2 [Vega]
ICGC DataPortalENSG00000100121
TCGA cBioPortalGGTLC2
AceView (NCBI)GGTLC2
Genatlas (Paris)GGTLC2
WikiGenes91227
SOURCE (Princeton)GGTLC2
Genetics Home Reference (NIH)GGTLC2
Genomic and cartography
GoldenPath hg38 (UCSC)GGTLC2  -     chr22:22644620-22647898 +  22q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GGTLC2  -     22q11.22   [Description]    (hg19-Feb_2009)
EnsemblGGTLC2 - 22q11.22 [CytoView hg19]  GGTLC2 - 22q11.22 [CytoView hg38]
Mapping of homologs : NCBIGGTLC2 [Mapview hg19]  GGTLC2 [Mapview hg38]
OMIM612339   
Gene and transcription
Genbank (Entrez)AI026655 AI138829 AW183356 BC069534 BX282400
RefSeq transcript (Entrez)NM_001282879 NM_080839 NM_199127
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GGTLC2
Cluster EST : UnigeneHs.632765 [ NCBI ]
CGAP (NCI)Hs.632765
Alternative Splicing GalleryENSG00000100121
Gene ExpressionGGTLC2 [ NCBI-GEO ]   GGTLC2 [ EBI - ARRAY_EXPRESS ]   GGTLC2 [ SEEK ]   GGTLC2 [ MEM ]
Gene Expression Viewer (FireBrowse)GGTLC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91227
GTEX Portal (Tissue expression)GGTLC2
Human Protein AtlasENSG00000100121-GGTLC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14390   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14390  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14390
Splice isoforms : SwissVarQ14390
PhosPhoSitePlusQ14390
Domaine pattern : Prosite (Expaxy)G_GLU_TRANSPEPTIDASE (PS00462)   
Domains : Interpro (EBI)GGT_peptidase    Ntn_hydrolases_N   
Domain families : Pfam (Sanger)G_glu_transpept (PF01019)   
Domain families : Pfam (NCBI)pfam01019   
Conserved Domain (NCBI)GGTLC2
DMDM Disease mutations91227
Blocks (Seattle)GGTLC2
SuperfamilyQ14390
Human Protein Atlas [tissue]ENSG00000100121-GGTLC2 [tissue]
Peptide AtlasQ14390
HPRD09971
IPIIPI00377039   IPI00098026   IPI00956228   
Protein Interaction databases
DIP (DOE-UCLA)Q14390
IntAct (EBI)Q14390
FunCoupENSG00000100121
BioGRIDGGTLC2
STRING (EMBL)GGTLC2
ZODIACGGTLC2
Ontologies - Pathways
QuickGOQ14390
Ontology : AmiGOgamma-glutamyltransferase activity  proteolysis  glutathione metabolic process  glutathione catabolic process  leukotriene biosynthetic process  anchored component of external side of plasma membrane  glutathione hydrolase activity  extracellular exosome  
Ontology : EGO-EBIgamma-glutamyltransferase activity  proteolysis  glutathione metabolic process  glutathione catabolic process  leukotriene biosynthetic process  anchored component of external side of plasma membrane  glutathione hydrolase activity  extracellular exosome  
NDEx NetworkGGTLC2
Atlas of Cancer Signalling NetworkGGTLC2
Wikipedia pathwaysGGTLC2
Orthology - Evolution
OrthoDB91227
GeneTree (enSembl)ENSG00000100121
Phylogenetic Trees/Animal Genes : TreeFamGGTLC2
HOVERGENQ14390
HOGENOMQ14390
Homologs : HomoloGeneGGTLC2
Homology/Alignments : Family Browser (UCSC)GGTLC2
Gene fusions - Rearrangements
Tumor Fusion PortalGGTLC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGGTLC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GGTLC2
dbVarGGTLC2
ClinVarGGTLC2
1000_GenomesGGTLC2 
Exome Variant ServerGGTLC2
ExAC (Exome Aggregation Consortium)ENSG00000100121
GNOMAD BrowserENSG00000100121
Genetic variants : HAPMAP91227
Genomic Variants (DGV)GGTLC2 [DGVbeta]
DECIPHERGGTLC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGGTLC2 
Mutations
ICGC Data PortalGGTLC2 
TCGA Data PortalGGTLC2 
Broad Tumor PortalGGTLC2
OASIS PortalGGTLC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGGTLC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGGTLC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GGTLC2
DgiDB (Drug Gene Interaction Database)GGTLC2
DoCM (Curated mutations)GGTLC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GGTLC2 (select a term)
intoGenGGTLC2
Cancer3DGGTLC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612339   
Orphanet
DisGeNETGGTLC2
MedgenGGTLC2
Genetic Testing Registry GGTLC2
NextProtQ14390 [Medical]
TSGene91227
GENETestsGGTLC2
Target ValidationGGTLC2
Huge Navigator GGTLC2 [HugePedia]
snp3D : Map Gene to Disease91227
BioCentury BCIQGGTLC2
ClinGenGGTLC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91227
Chemical/Pharm GKB GenePA162389523
Clinical trialGGTLC2
Miscellaneous
canSAR (ICR)GGTLC2 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGGTLC2
EVEXGGTLC2
GoPubMedGGTLC2
iHOPGGTLC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:43:41 CET 2017

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