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GHRH (growth hormone releasing hormone)

Identity

Alias_namesGHRF
Other aliasGRF
INN
HGNC (Hugo) GHRH
LocusID (NCBI) 2691
Atlas_Id 40712
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 37251086 and ends at 37256908 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADNP (20q13.13) / GHRH (20q11.23)EPB41L1 (20q11.23) / GHRH (20q11.23)ADNP 20q13.13 / GHRH 20q11.23
EPB41L1 20q11.23 / GHRH 20q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GHRH   4265
Cards
Entrez_Gene (NCBI)GHRH  2691  growth hormone releasing hormone
AliasesGHRF; GRF; INN
GeneCards (Weizmann)GHRH
Ensembl hg19 (Hinxton)ENSG00000118702 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118702 [Gene_View]  chr20:37251086-37256908 [Contig_View]  GHRH [Vega]
ICGC DataPortalENSG00000118702
TCGA cBioPortalGHRH
AceView (NCBI)GHRH
Genatlas (Paris)GHRH
WikiGenes2691
SOURCE (Princeton)GHRH
Genetics Home Reference (NIH)GHRH
Genomic and cartography
GoldenPath hg38 (UCSC)GHRH  -     chr20:37251086-37256908 -  20q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GHRH  -     20q11.23   [Description]    (hg19-Feb_2009)
EnsemblGHRH - 20q11.23 [CytoView hg19]  GHRH - 20q11.23 [CytoView hg38]
Mapping of homologs : NCBIGHRH [Mapview hg19]  GHRH [Mapview hg38]
OMIM139190   
Gene and transcription
Genbank (Entrez)AI631051 AW134884 BC098109 BC098161 BC099727
RefSeq transcript (Entrez)NM_001184731 NM_021081
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GHRH
Cluster EST : UnigeneHs.37023 [ NCBI ]
CGAP (NCI)Hs.37023
Alternative Splicing GalleryENSG00000118702
Gene ExpressionGHRH [ NCBI-GEO ]   GHRH [ EBI - ARRAY_EXPRESS ]   GHRH [ SEEK ]   GHRH [ MEM ]
Gene Expression Viewer (FireBrowse)GHRH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2691
GTEX Portal (Tissue expression)GHRH
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01286   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01286  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01286
Splice isoforms : SwissVarP01286
PhosPhoSitePlusP01286
Domaine pattern : Prosite (Expaxy)GLUCAGON (PS00260)   
Domains : Interpro (EBI)Glucagon_GIP_secretin_VIP   
Domain families : Pfam (Sanger)Hormone_2 (PF00123)   
Domain families : Pfam (NCBI)pfam00123   
Domain families : Smart (EMBL)GLUCA (SM00070)  
Conserved Domain (NCBI)GHRH
DMDM Disease mutations2691
Blocks (Seattle)GHRH
PDB (SRS)5BQM   
PDB (PDBSum)5BQM   
PDB (IMB)5BQM   
PDB (RSDB)5BQM   
Structural Biology KnowledgeBase5BQM   
SCOP (Structural Classification of Proteins)5BQM   
CATH (Classification of proteins structures)5BQM   
SuperfamilyP01286
Human Protein AtlasENSG00000118702
Peptide AtlasP01286
HPRD11752
IPIIPI00000961   IPI00783260   
Protein Interaction databases
DIP (DOE-UCLA)P01286
IntAct (EBI)P01286
FunCoupENSG00000118702
BioGRIDGHRH
STRING (EMBL)GHRH
ZODIACGHRH
Ontologies - Pathways
QuickGOP01286
Ontology : AmiGOextracellular region  extracellular region  extracellular space  intracellular  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  cell-cell signaling  positive regulation of cell proliferation  growth hormone-releasing hormone activity  cAMP-mediated signaling  adenohypophysis development  growth hormone secretion  positive regulation of cAMP biosynthetic process  growth hormone-releasing hormone receptor binding  response to food  positive regulation of multicellular organism growth  terminal bouton  positive regulation of insulin-like growth factor receptor signaling pathway  positive regulation of circadian sleep/wake cycle, REM sleep  positive regulation of circadian sleep/wake cycle, REM sleep  positive regulation of growth hormone secretion  positive regulation of growth hormone secretion  positive regulation of growth hormone secretion  
Ontology : EGO-EBIextracellular region  extracellular region  extracellular space  intracellular  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  cell-cell signaling  positive regulation of cell proliferation  growth hormone-releasing hormone activity  cAMP-mediated signaling  adenohypophysis development  growth hormone secretion  positive regulation of cAMP biosynthetic process  growth hormone-releasing hormone receptor binding  response to food  positive regulation of multicellular organism growth  terminal bouton  positive regulation of insulin-like growth factor receptor signaling pathway  positive regulation of circadian sleep/wake cycle, REM sleep  positive regulation of circadian sleep/wake cycle, REM sleep  positive regulation of growth hormone secretion  positive regulation of growth hormone secretion  positive regulation of growth hormone secretion  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]   
NDEx NetworkGHRH
Atlas of Cancer Signalling NetworkGHRH
Wikipedia pathwaysGHRH
Orthology - Evolution
OrthoDB2691
GeneTree (enSembl)ENSG00000118702
Phylogenetic Trees/Animal Genes : TreeFamGHRH
HOVERGENP01286
HOGENOMP01286
Homologs : HomoloGeneGHRH
Homology/Alignments : Family Browser (UCSC)GHRH
Gene fusions - Rearrangements
Fusion : MitelmanADNP/GHRH [20q13.13/20q11.23]  [t(20;20)(q11;q13)]  
Fusion : MitelmanEPB41L1/GHRH [20q11.23/20q11.23]  [t(20;20)(q11;q11)]  
Fusion: TCGAADNP 20q13.13 GHRH 20q11.23 BRCA
Fusion: TCGAEPB41L1 20q11.23 GHRH 20q11.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGHRH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GHRH
dbVarGHRH
ClinVarGHRH
1000_GenomesGHRH 
Exome Variant ServerGHRH
ExAC (Exome Aggregation Consortium)GHRH (select the gene name)
Genetic variants : HAPMAP2691
Genomic Variants (DGV)GHRH [DGVbeta]
DECIPHERGHRH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGHRH 
Mutations
ICGC Data PortalGHRH 
TCGA Data PortalGHRH 
Broad Tumor PortalGHRH
OASIS PortalGHRH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGHRH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGHRH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GHRH
DgiDB (Drug Gene Interaction Database)GHRH
DoCM (Curated mutations)GHRH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GHRH (select a term)
intoGenGHRH
Cancer3DGHRH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139190   
Orphanet
MedgenGHRH
Genetic Testing Registry GHRH
NextProtP01286 [Medical]
TSGene2691
GENETestsGHRH
Target ValidationGHRH
Huge Navigator GHRH [HugePedia]
snp3D : Map Gene to Disease2691
BioCentury BCIQGHRH
ClinGenGHRH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2691
Chemical/Pharm GKB GenePA28675
Clinical trialGHRH
Miscellaneous
canSAR (ICR)GHRH (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGHRH
EVEXGHRH
GoPubMedGHRH
iHOPGHRH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:35:11 CEST 2017

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