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GHRHR (growth hormone releasing hormone receptor)

Identity

Other namesGHRFR
GRFR
IGHD1B
HGNC (Hugo) GHRHR
LocusID (NCBI) 2692
Location 7p14.3
Location_base_pair Starts at 31003636 and ends at 31019146 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GHRHR   4266
Cards
Entrez_Gene (NCBI)GHRHR  2692  growth hormone releasing hormone receptor
GeneCards (Weizmann)GHRHR
Ensembl (Hinxton)ENSG00000106128 [Gene_View]  chr7:31003636-31019146 [Contig_View]  GHRHR [Vega]
ICGC DataPortalENSG00000106128
cBioPortalGHRHR
AceView (NCBI)GHRHR
Genatlas (Paris)GHRHR
WikiGenes2692
SOURCE (Princeton)NM_000823 NM_001009824
Genomic and cartography
GoldenPath (UCSC)GHRHR  -  7p14.3   chr7:31003636-31019146 +  7p14.3   [Description]    (hg19-Feb_2009)
EnsemblGHRHR - 7p14.3 [CytoView]
Mapping of homologs : NCBIGHRHR [Mapview]
OMIM139191   612781   
Gene and transcription
Genbank (Entrez)AB058895 AF282259 AF282260 AF282261 AF282262
RefSeq transcript (Entrez)NM_000823 NM_001009824
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_021416 NT_007819 NW_001839003 NW_004929329
Consensus coding sequences : CCDS (NCBI)GHRHR
Cluster EST : UnigeneHs.733003 [ NCBI ]
CGAP (NCI)Hs.733003
Alternative Splicing : Fast-db (Paris)GSHG0027257
Alternative Splicing GalleryENSG00000106128
Gene ExpressionGHRHR [ NCBI-GEO ]     GHRHR [ SEEK ]   GHRHR [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02643 (Uniprot)
NextProtQ02643  [Medical]
With graphics : InterProQ02643
Splice isoforms : SwissVarQ02643 (Swissvar)
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_1 (PS00649)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)GPCR_2-like [organisation]   GPCR_2_extracellular_dom [organisation]   GPCR_2_GHRH_rcpt [organisation]   GPCR_2_secretin-like [organisation]   GPCR_2_secretin-like_CS [organisation]  
Related proteins : CluSTrQ02643
Domain families : Pfam (Sanger)7tm_2 (PF00002)    HRM (PF02793)   
Domain families : Pfam (NCBI)pfam00002    pfam02793   
Domain families : Smart (EMBL)HormR (SM00008)  
DMDM Disease mutations2692
Blocks (Seattle)Q02643
PDB (SRS)2XDG   
PDB (PDBSum)2XDG   
PDB (IMB)2XDG   
PDB (RSDB)2XDG   
Human Protein AtlasENSG00000106128 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ02643
HPRD00748
IPIIPI00295079   IPI00940022   IPI00816651   IPI00166984   IPI00029518   IPI00477889   IPI00386985   IPI00917002   IPI00386984   
Protein Interaction databases
DIP (DOE-UCLA)Q02643
IntAct (EBI)Q02643
FunCoupENSG00000106128
BioGRIDGHRHR
InParanoidQ02643
Interologous Interaction database Q02643
IntegromeDBGHRHR
STRING (EMBL)GHRHR
Ontologies - Pathways
Ontology : AmiGOG-protein coupled receptor activity  protein binding  nuclear inner membrane  nuclear outer membrane  cytoplasm  plasma membrane  plasma membrane  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  lactation  positive regulation of cell proliferation  determination of adult lifespan  cell surface  integral component of membrane  nuclear matrix  growth hormone-releasing hormone receptor activity  peptide hormone binding  growth factor binding  cAMP-mediated signaling  water homeostasis  secretory granule  growth hormone secretion  positive regulation of cAMP biosynthetic process  response to insulin  cellular response to insulin stimulus  regulation of intracellular steroid hormone receptor signaling pathway  positive regulation of multicellular organism growth  hormone metabolic process  positive regulation of insulin-like growth factor receptor signaling pathway  response to estrogen  cell maturation  multicellular organismal reproductive process  regulation of protein metabolic process  response to glucocorticoid  positive regulation of growth hormone secretion  somatotropin secreting cell development  
Ontology : EGO-EBIG-protein coupled receptor activity  protein binding  nuclear inner membrane  nuclear outer membrane  cytoplasm  plasma membrane  plasma membrane  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  lactation  positive regulation of cell proliferation  determination of adult lifespan  cell surface  integral component of membrane  nuclear matrix  growth hormone-releasing hormone receptor activity  peptide hormone binding  growth factor binding  cAMP-mediated signaling  water homeostasis  secretory granule  growth hormone secretion  positive regulation of cAMP biosynthetic process  response to insulin  cellular response to insulin stimulus  regulation of intracellular steroid hormone receptor signaling pathway  positive regulation of multicellular organism growth  hormone metabolic process  positive regulation of insulin-like growth factor receptor signaling pathway  response to estrogen  cell maturation  multicellular organismal reproductive process  regulation of protein metabolic process  response to glucocorticoid  positive regulation of growth hormone secretion  somatotropin secreting cell development  
Pathways : KEGGNeuroactive ligand-receptor interaction   
Protein Interaction DatabaseGHRHR
Wikipedia pathwaysGHRHR
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GHRHR
snp3D : Map Gene to Disease2692
SNP (GeneSNP Utah)GHRHR
SNP : HGBaseGHRHR
Genetic variants : HAPMAPGHRHR
Exome VariantGHRHR
1000_GenomesGHRHR 
ICGC programENSG00000106128 
Somatic Mutations in Cancer : COSMICGHRHR 
CONAN: Copy Number AnalysisGHRHR 
Mutations and Diseases : HGMDGHRHR
Mutations and Diseases : intOGenGHRHR
Genomic VariantsGHRHR  GHRHR [DGVbeta]
dbVarGHRHR
ClinVarGHRHR
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM139191    612781   
MedgenGHRHR
GENETestsGHRHR
Disease Genetic AssociationGHRHR
Huge Navigator GHRHR [HugePedia]  GHRHR [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneGHRHR
Homology/Alignments : Family Browser (UCSC)GHRHR
Phylogenetic Trees/Animal Genes : TreeFamGHRHR
Chemical/Protein Interactions : CTD2692
Chemical/Pharm GKB GenePA28676
Clinical trialGHRHR
Cancer Resource (Charite)ENSG00000106128
Other databases
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
CoreMineGHRHR
iHOPGHRHR
OncoSearchGHRHR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:47:59 CEST 2014

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