GIGYF2 (GRB10 interacting GYF protein 2)

2014-08-01 Affiliation

Identity

HGNC

GIGYF2

LOCATION

2q37.1

LOCUSID

26058

ALIAS

GYF2,PARK11,PERQ2,PERQ3,TNRC15

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 26058
MIM: 612003
HGNC: 11960
Ensembl: ENSG00000204120

Variants:

dbSNP: 26058
ClinVar: 26058
TCGA: ENSG00000204120
COSMIC: GIGYF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204120	ENST00000373563	Q6Y7W6
ENSG00000204120	ENST00000409196	Q6Y7W6
ENSG00000204120	ENST00000409451	Q6Y7W6
ENSG00000204120	ENST00000409480	I1E4Y6
ENSG00000204120	ENST00000409547	Q6Y7W6
ENSG00000204120	ENST00000410033	B8ZZD2
ENSG00000204120	ENST00000421433	C9JPV7
ENSG00000204120	ENST00000421778	C9JH78
ENSG00000204120	ENST00000423659	C9JHW1
ENSG00000204120	ENST00000424038	F8WCD5
ENSG00000204120	ENST00000424414	C9JZC0
ENSG00000204120	ENST00000425040	C9JXQ0
ENSG00000204120	ENST00000426102	C9JH18
ENSG00000204120	ENST00000427233	C9JC65
ENSG00000204120	ENST00000427649	C9J7G1
ENSG00000204120	ENST00000428883	C9JRZ2
ENSG00000204120	ENST00000429187	C9J0V6
ENSG00000204120	ENST00000430720	C9JHT0
ENSG00000204120	ENST00000436349	C9J1A6
ENSG00000204120	ENST00000440945	E7ESB6
ENSG00000204120	ENST00000445650	C9IYH5
ENSG00000204120	ENST00000455139	A0A1U8QZH8
ENSG00000204120	ENST00000456491	C9JW88
ENSG00000204120	ENST00000458528	F8WBF1
ENSG00000204120	ENST00000629305	I1E4Y6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
22751931	2012	A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.	50
18358451	2008	Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease.	33
18358451	2008	Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease.	33
18923002	2009	Lack of replication of association between GIGYF2 variants and Parkinson disease.	11
18923002	2009	Lack of replication of association between GIGYF2 variants and Parkinson disease.	11
20060621	2011	Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene.	8
20060621	2011	Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene.	8
26152800	2015	The contribution of GIGYF2 to Parkinson's disease: a meta-analysis.	7
27157137	2016	Post-transcriptional gene silencing activity of human GIGYF2.	7

Citation

Dessen P

GIGYF2 (GRB10 interacting GYF protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54331/gigyf2