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GIGYF2 (GRB10 interacting GYF protein 2)

Identity

Alias (NCBI)GYF2
PARK11
PERQ2
PERQ3
TNRC15
HGNC (Hugo) GIGYF2
HGNC Alias symbKIAA0642
GYF2
HGNC Alias nameGYF domain containing 2
HGNC Previous namePERQ2
 PERQ3
 TNRC15
 PARK11
HGNC Previous namePERQ amino acid rich, with GYF domain 2
 PERQ amino acid rich, with GYF domain 3
 trinucleotide repeat containing 15
 Parkinson disease (autosomal recessive, early onset) 11
LocusID (NCBI) 26058
Atlas_Id 54331
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 232697331 and ends at 232860577 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHCTF1 (1q44) / GIGYF2 (2q37.1)APC2 (19p13.3) / GIGYF2 (2q37.1)ATRN (20p13) / GIGYF2 (2q37.1)
CRTC3 (15q26.1) / GIGYF2 (2q37.1)GABARAPL1 (12p13.2) / GIGYF2 (2q37.1)GIGYF2 (2q37.1) / ASB18 (2q37.2)
GIGYF2 (2q37.1) / BMPER (7p14.3)GIGYF2 (2q37.1) / CHRND (2q37.1)GIGYF2 (2q37.1) / DIS3L2 (2q37.1)
GIGYF2 (2q37.1) / ECEL1 (2q37.1)GIGYF2 (2q37.1) / EFHD1 (2q37.1)GIGYF2 (2q37.1) / EIF4E2 (2q37.1)
GIGYF2 (2q37.1) / GAB3 (Xq28)GIGYF2 (2q37.1) / GIGYF2 (2q37.1)GIGYF2 (2q37.1) / MROH2A (2q37.1)
GIGYF2 (2q37.1) / PPP1R7 (2q37.3)GIGYF2 (2q37.1) / SLC6A20 (3p21.31)GIGYF2 (2q37.1) / TMEM163 (2q21.3)
GIGYF2 (2q37.1) / TRPM8 (2q37.1)GIGYF2 (2q37.1) / XRCC5 (2q35)PRR4 (12p13.2) / GIGYF2 (2q37.1)
APC2 19p13.3 / GIGYF2 2q37.1GIGYF2 2q37.1 / CHRND 2q37.1GIGYF2 2q37.1 / DIS3L2 2q37.1
GIGYF2 2q37.1 / EFHD1 2q37.1GIGYF2 2q37.1 / EIF4E2 2q37.1GIGYF2 2q37.1 HEATR7B1
GIGYF2 2q37.1 / TMEM163 2q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GIGYF2   11960
Cards
Entrez_Gene (NCBI)GIGYF2    GRB10 interacting GYF protein 2
AliasesGYF2; PARK11; PERQ2; PERQ3; 
TNRC15
GeneCards (Weizmann)GIGYF2
Ensembl hg19 (Hinxton)ENSG00000204120 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204120 [Gene_View]  ENSG00000204120 [Sequence]  chr2:232697331-232860577 [Contig_View]  GIGYF2 [Vega]
ICGC DataPortalENSG00000204120
TCGA cBioPortalGIGYF2
AceView (NCBI)GIGYF2
Genatlas (Paris)GIGYF2
SOURCE (Princeton)GIGYF2
Genetics Home Reference (NIH)GIGYF2
Genomic and cartography
GoldenPath hg38 (UCSC)GIGYF2  -     chr2:232697331-232860577 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GIGYF2  -     2q37.1   [Description]    (hg19-Feb_2009)
GoldenPathGIGYF2 - 2q37.1 [CytoView hg19]  GIGYF2 - 2q37.1 [CytoView hg38]
ImmunoBaseENSG00000204120
Genome Data Viewer NCBIGIGYF2 [Mapview hg19]  
OMIM607688   612003   
Gene and transcription
Genbank (Entrez)AB014542 AK001739 AK027021 AK297162 AK299418
RefSeq transcript (Entrez)NM_001103146 NM_001103147 NM_001103148 NM_015575
Consensus coding sequences : CCDS (NCBI)GIGYF2
Gene ExpressionGIGYF2 [ NCBI-GEO ]   GIGYF2 [ EBI - ARRAY_EXPRESS ]   GIGYF2 [ SEEK ]   GIGYF2 [ MEM ]
Gene Expression Viewer (FireBrowse)GIGYF2 [ Firebrowse - Broad ]
GenevisibleExpression of GIGYF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26058
GTEX Portal (Tissue expression)GIGYF2
Human Protein AtlasENSG00000204120-GIGYF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6Y7W6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6Y7W6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6Y7W6
PhosPhoSitePlusQ6Y7W6
Domaine pattern : Prosite (Expaxy)GYF (PS50829)   
Domains : Interpro (EBI)GYF    GYF-like_dom_sf   
Domain families : Pfam (Sanger)GYF (PF02213)   
Domain families : Pfam (NCBI)pfam02213   
Domain families : Smart (EMBL)GYF (SM00444)  
Conserved Domain (NCBI)GIGYF2
PDB (RSDB)5NVL    5NVM   
PDB Europe5NVL    5NVM   
PDB (PDBSum)5NVL    5NVM   
PDB (IMB)5NVL    5NVM   
Structural Biology KnowledgeBase5NVL    5NVM   
SCOP (Structural Classification of Proteins)5NVL    5NVM   
CATH (Classification of proteins structures)5NVL    5NVM   
SuperfamilyQ6Y7W6
AlphaFold pdb e-kbQ6Y7W6   
Human Protein Atlas [tissue]ENSG00000204120-GIGYF2 [tissue]
HPRD11639
Protein Interaction databases
DIP (DOE-UCLA)Q6Y7W6
IntAct (EBI)Q6Y7W6
BioGRIDGIGYF2
STRING (EMBL)GIGYF2
ZODIACGIGYF2
Ontologies - Pathways
QuickGOQ6Y7W6
Ontology : AmiGORNA binding  protein binding  endosome  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  feeding behavior  adult locomotory behavior  post-embryonic development  cytoplasmic stress granule  membrane  membrane  integral component of membrane  posttranscriptional gene silencing  negative regulation of translation  spinal cord motor neuron differentiation  mitotic G1 DNA damage checkpoint signaling  vesicle  protein-containing complex  multicellular organism growth  perikaryon  perikaryon  cellular protein metabolic process  cadherin binding  insulin-like growth factor receptor signaling pathway  insulin-like growth factor receptor signaling pathway  homeostasis of number of cells within a tissue  musculoskeletal movement  neuromuscular process controlling balance  mRNA destabilization  proline-rich region binding  proximal dendrite  proximal dendrite  
Ontology : EGO-EBIRNA binding  protein binding  endosome  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  feeding behavior  adult locomotory behavior  post-embryonic development  cytoplasmic stress granule  membrane  membrane  integral component of membrane  posttranscriptional gene silencing  negative regulation of translation  spinal cord motor neuron differentiation  mitotic G1 DNA damage checkpoint signaling  vesicle  protein-containing complex  multicellular organism growth  perikaryon  perikaryon  cellular protein metabolic process  cadherin binding  insulin-like growth factor receptor signaling pathway  insulin-like growth factor receptor signaling pathway  homeostasis of number of cells within a tissue  musculoskeletal movement  neuromuscular process controlling balance  mRNA destabilization  proline-rich region binding  proximal dendrite  proximal dendrite  
NDEx NetworkGIGYF2
Atlas of Cancer Signalling NetworkGIGYF2
Wikipedia pathwaysGIGYF2
Orthology - Evolution
OrthoDB26058
GeneTree (enSembl)ENSG00000204120
Phylogenetic Trees/Animal Genes : TreeFamGIGYF2
Homologs : HomoloGeneGIGYF2
Homology/Alignments : Family Browser (UCSC)GIGYF2
Gene fusions - Rearrangements
Fusion : MitelmanAPC2/GIGYF2 [19p13.3/2q37.1]  
Fusion : MitelmanGIGYF2/ASB18 [2q37.1/2q37.2]  
Fusion : MitelmanGIGYF2/CHRND [2q37.1/2q37.1]  
Fusion : MitelmanGIGYF2/DIS3L2 [2q37.1/2q37.1]  
Fusion : MitelmanGIGYF2/ECEL1 [2q37.1/2q37.1]  
Fusion : MitelmanGIGYF2/EFHD1 [2q37.1/2q37.1]  
Fusion : MitelmanGIGYF2/EIF4E2 [2q37.1/2q37.1]  
Fusion : MitelmanGIGYF2/MROH2A [2q37.1/2q37.1]  
Fusion : MitelmanGIGYF2/PPP1R7 [2q37.1/2q37.3]  
Fusion : MitelmanGIGYF2/TMEM163 [2q37.1/2q21.3]  
Fusion : MitelmanGIGYF2/TRPM8 [2q37.1/2q37.1]  
Fusion : QuiverGIGYF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGIGYF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GIGYF2
dbVarGIGYF2
ClinVarGIGYF2
MonarchGIGYF2
1000_GenomesGIGYF2 
Exome Variant ServerGIGYF2
GNOMAD BrowserENSG00000204120
Varsome BrowserGIGYF2
ACMGGIGYF2 variants
VarityQ6Y7W6
Genomic Variants (DGV)GIGYF2 [DGVbeta]
DECIPHERGIGYF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGIGYF2 
Mutations
ICGC Data PortalGIGYF2 
TCGA Data PortalGIGYF2 
Broad Tumor PortalGIGYF2
OASIS PortalGIGYF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGIGYF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGIGYF2
Mutations and Diseases : HGMDGIGYF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGIGYF2
DgiDB (Drug Gene Interaction Database)GIGYF2
DoCM (Curated mutations)GIGYF2
CIViC (Clinical Interpretations of Variants in Cancer)GIGYF2
Cancer3DGIGYF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607688    612003   
Orphanet23022   
DisGeNETGIGYF2
MedgenGIGYF2
Genetic Testing Registry GIGYF2
NextProtQ6Y7W6 [Medical]
GENETestsGIGYF2
Target ValidationGIGYF2
Huge Navigator GIGYF2 [HugePedia]
ClinGenGIGYF2
Clinical trials, drugs, therapy
MyCancerGenomeGIGYF2
Protein Interactions : CTDGIGYF2
Pharm GKB GenePA36647
PharosQ6Y7W6
Clinical trialGIGYF2
Miscellaneous
canSAR (ICR)GIGYF2
HarmonizomeGIGYF2
DataMed IndexGIGYF2
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGIGYF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:10:44 CEST 2021

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