GINS1 (GINS complex subunit 1)

2010-03-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
IMD55,PSF1
FUSION GENES

Other Information

Locus ID:

NCBI: 9837
MIM: 610608
HGNC: 28980
Ensembl: ENSG00000101003

Variants:

dbSNP: 9837
ClinVar: 9837
TCGA: ENSG00000101003
COSMIC: GINS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101003ENST00000262460Q14691

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
GINS complexKEGGhsa_M00286
GINS complexKEGGM00286
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174176532007Structure of the human GINS complex and its assembly and functional interface in replication initiation.34
284142932017Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency.29
201036372010PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.18
208254912010Up-regulation of PSF1 promotes the growth of breast cancer cells.16
171272132006A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.7
280717572017New insights into the GINS complex explain the controversy between existing structural models.3
304136052018Up-regulated and interrelated expressions of GINS subunits predict poor prognosis in hepatocellular carcinoma.2
217137062011[Expression and clinical significance of GINS complex in colorectal cancer].1
304650752019Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma.1

Citation

Dessen P

GINS1 (GINS complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51386/gins1