Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GK5 (glycerol kinase 5)

Identity

Alias (NCBI)-
HGNC (Hugo) GK5
HGNC Alias symbMGC40579
HGNC Previous nameglycerol kinase 5 (putative)
LocusID (NCBI) 256356
Atlas_Id 55681
Location 3q23  [Link to chromosome band 3q23]
Location_base_pair Starts at 142157527 and ends at 142225585 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC6 (17q21.2) / GK5 (3q23)GK5 (3q23) / MBNL1 (3q25.1)GK5 (3q23) / PAQR9 (3q23)
TFDP2 (3q23) / GK5 (3q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;3)(q23;q25) GK5/MBNL1

External links

Nomenclature
HGNC (Hugo)GK5   28635
Cards
Entrez_Gene (NCBI)GK5    glycerol kinase 5
Aliases
GeneCards (Weizmann)GK5
Ensembl hg19 (Hinxton)ENSG00000175066 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175066 [Gene_View]  ENSG00000175066 [Sequence]  chr3:142157527-142225585 [Contig_View]  GK5 [Vega]
ICGC DataPortalENSG00000175066
TCGA cBioPortalGK5
AceView (NCBI)GK5
Genatlas (Paris)GK5
SOURCE (Princeton)GK5
Genetics Home Reference (NIH)GK5
Genomic and cartography
GoldenPath hg38 (UCSC)GK5  -     chr3:142157527-142225585 -  3q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GK5  -     3q23   [Description]    (hg19-Feb_2009)
GoldenPathGK5 - 3q23 [CytoView hg19]  GK5 - 3q23 [CytoView hg38]
ImmunoBaseENSG00000175066
genome Data Viewer NCBIGK5 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK090901 AK127641 AK130469 AK310761 AK313792
RefSeq transcript (Entrez)NM_001039547 NM_152776
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GK5
Alternative Splicing GalleryENSG00000175066
Gene ExpressionGK5 [ NCBI-GEO ]   GK5 [ EBI - ARRAY_EXPRESS ]   GK5 [ SEEK ]   GK5 [ MEM ]
Gene Expression Viewer (FireBrowse)GK5 [ Firebrowse - Broad ]
GenevisibleExpression of GK5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)256356
GTEX Portal (Tissue expression)GK5
Human Protein AtlasENSG00000175066-GK5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZS86   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZS86  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZS86
Splice isoforms : SwissVarQ6ZS86
Catalytic activity : Enzyme2.7.1.30 [ Enzyme-Expasy ]   2.7.1.302.7.1.30 [ IntEnz-EBI ]   2.7.1.30 [ BRENDA ]   2.7.1.30 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ6ZS86
Domaine pattern : Prosite (Expaxy)FGGY_KINASES_2 (PS00445)   
Domains : Interpro (EBI)Carb_kinase_FGGY    Carb_kinase_FGGY_C    Carb_kinase_FGGY_CS    Carb_kinase_FGGY_N    GK5_FGGY   
Domain families : Pfam (Sanger)FGGY_C (PF02782)    FGGY_N (PF00370)   
Domain families : Pfam (NCBI)pfam02782    pfam00370   
Conserved Domain (NCBI)GK5
Blocks (Seattle)GK5
SuperfamilyQ6ZS86
Human Protein Atlas [tissue]ENSG00000175066-GK5 [tissue]
Peptide AtlasQ6ZS86
HPRD14612
IPIIPI00791183   IPI00744122   IPI00166847   IPI00946992   IPI00946568   IPI00946271   IPI00947320   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZS86
IntAct (EBI)Q6ZS86
BioGRIDGK5
STRING (EMBL)GK5
ZODIACGK5
Ontologies - Pathways
QuickGOQ6ZS86
Ontology : AmiGOglycerol kinase activity  ATP binding  mitochondrion  glycerol metabolic process  triglyceride metabolic process  phosphorylation  phosphotransferase activity, alcohol group as acceptor  glycerol catabolic process  glycerol-3-phosphate biosynthetic process  
Ontology : EGO-EBIglycerol kinase activity  ATP binding  mitochondrion  glycerol metabolic process  triglyceride metabolic process  phosphorylation  phosphotransferase activity, alcohol group as acceptor  glycerol catabolic process  glycerol-3-phosphate biosynthetic process  
NDEx NetworkGK5
Atlas of Cancer Signalling NetworkGK5
Wikipedia pathwaysGK5
Orthology - Evolution
OrthoDB256356
GeneTree (enSembl)ENSG00000175066
Phylogenetic Trees/Animal Genes : TreeFamGK5
HOGENOMQ6ZS86
Homologs : HomoloGeneGK5
Homology/Alignments : Family Browser (UCSC)GK5
Gene fusions - Rearrangements
Fusion : QuiverGK5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGK5 [hg38]
dbVarGK5
ClinVarGK5
MonarchGK5
1000_GenomesGK5 
Exome Variant ServerGK5
GNOMAD BrowserENSG00000175066
Varsome BrowserGK5
Genomic Variants (DGV)GK5 [DGVbeta]
DECIPHERGK5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGK5 
Mutations
ICGC Data PortalGK5 
TCGA Data PortalGK5 
Broad Tumor PortalGK5
OASIS PortalGK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGK5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGK5
Mutations and Diseases : HGMDGK5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GK5
DgiDB (Drug Gene Interaction Database)GK5
DoCM (Curated mutations)GK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GK5 (select a term)
intoGenGK5
Cancer3DGK5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETGK5
MedgenGK5
Genetic Testing Registry GK5
NextProtQ6ZS86 [Medical]
GENETestsGK5
Target ValidationGK5
Huge Navigator GK5 [HugePedia]
ClinGenGK5
Clinical trials, drugs, therapy
MyCancerGenomeGK5
Protein Interactions : CTD
Pharm GKB GenePA162389723
PharosQ6ZS86
Clinical trialGK5
Miscellaneous
canSAR (ICR)GK5 (select the gene name)
HarmonizomeGK5
DataMed IndexGK5
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:17:06 CET 2021
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