GLCCI1 (glucocorticoid induced 1)

2014-11-01  

Identity

HGNC
LOCATION
7p21.3
LOCUSID
ALIAS
FAM117C,GCTR,GIG18,TSSN1
FUSION GENES

Other Information

Locus ID:

NCBI: 113263
MIM: 614283
HGNC: 18713
Ensembl: ENSG00000106415

Variants:

dbSNP: 113263
ClinVar: 113263
TCGA: ENSG00000106415
COSMIC: GLCCI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106415ENST00000223145Q86VQ1
ENSG00000106415ENST00000414914H7C2L5
ENSG00000106415ENST00000430798H7C0Q2
ENSG00000106415ENST00000438949H7C0B2

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalVariantAnnotationnot associatedPD27523435
PA443450AsthmaDiseaseClinicalAnnotation, VariantAnnotationambiguousPD21991891, 27523435
PA448681budesonideChemicalClinicalAnnotationassociatedPD21991891
PA449661flunisolideChemicalClinicalAnnotationassociatedPD21991891
PA449686fluticasone propionateChemicalClinicalAnnotationassociatedPD21991891
PA450601nedocromilChemicalClinicalAnnotationassociatedPD21991891
PA451749triamcinoloneChemicalClinicalAnnotationassociatedPD21991891
PA452347glucocorticoidsChemicalClinicalAnnotationassociatedPD21991891

References

Pubmed IDYearTitleCitations
219918912011Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.96
238367802013Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.15
241318252014GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma.10
246736012014GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids.8
271337122016GLCCI1 Variation Is Associated with Asthma Susceptibility and Inhaled Corticosteroid Response in a Chinese Han Population.8
248972872014Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids.7
226609542012GLCCI1 single nucleotide polymorphisms in pediatric nephrotic syndrome.5
223045732012Variation at GLCCI1 and FCER2: one step closer to personalized asthma treatment.4
227960222012Genetic variation in GLCCI1 and dexamethasone in bacterial meningitis.4
257244722015Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis.4

Citation

Dessen P

GLCCI1 (glucocorticoid induced 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63813/glcci1