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GLDC (glycine decarboxylase)

Identity

Alias_namesglycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P)
glycine dehydrogenase (decarboxylating)
Alias_symbol (synonym)GCSP
NKH
Other aliasGCE
HYGN1
HGNC (Hugo) GLDC
LocusID (NCBI) 2731
Atlas_Id 52629
Location 9p24.1  [Link to chromosome band 9p24]
Location_base_pair Starts at 6532464 and ends at 6645692 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
JAK2 (9p24.1) / GLDC (9p24.1)RFX3 (9p24.2) / GLDC (9p24.1)JAK2 9p24.1 / GLDC 9p24.1
RFX3 9p24.2 / GLDC 9p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLDC   4313
LRG (Locus Reference Genomic)LRG_643
Cards
Entrez_Gene (NCBI)GLDC  2731  glycine decarboxylase
AliasesGCE; GCSP; HYGN1
GeneCards (Weizmann)GLDC
Ensembl hg19 (Hinxton)ENSG00000178445 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178445 [Gene_View]  chr9:6532464-6645692 [Contig_View]  GLDC [Vega]
ICGC DataPortalENSG00000178445
TCGA cBioPortalGLDC
AceView (NCBI)GLDC
Genatlas (Paris)GLDC
WikiGenes2731
SOURCE (Princeton)GLDC
Genetics Home Reference (NIH)GLDC
Genomic and cartography
GoldenPath hg38 (UCSC)GLDC  -     chr9:6532464-6645692 -  9p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLDC  -     9p24.1   [Description]    (hg19-Feb_2009)
EnsemblGLDC - 9p24.1 [CytoView hg19]  GLDC - 9p24.1 [CytoView hg38]
Mapping of homologs : NCBIGLDC [Mapview hg19]  GLDC [Mapview hg38]
OMIM238300   605899   
Gene and transcription
Genbank (Entrez)AI480362 AK308470 AK310534 AK314156 AW593954
RefSeq transcript (Entrez)NM_000170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLDC
Cluster EST : UnigeneHs.584238 [ NCBI ]
CGAP (NCI)Hs.584238
Alternative Splicing GalleryENSG00000178445
Gene ExpressionGLDC [ NCBI-GEO ]   GLDC [ EBI - ARRAY_EXPRESS ]   GLDC [ SEEK ]   GLDC [ MEM ]
Gene Expression Viewer (FireBrowse)GLDC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2731
GTEX Portal (Tissue expression)GLDC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23378   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23378  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23378
Splice isoforms : SwissVarP23378
Catalytic activity : Enzyme1.4.4.2 [ Enzyme-Expasy ]   1.4.4.21.4.4.2 [ IntEnz-EBI ]   1.4.4.2 [ BRENDA ]   1.4.4.2 [ KEGG ]   
PhosPhoSitePlusP23378
Domains : Interpro (EBI)ArAA_b-elim_lyase/Thr_aldolase    GcvP    GDC_P    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1   
Domain families : Pfam (Sanger)Beta_elim_lyase (PF01212)    GDC-P (PF02347)   
Domain families : Pfam (NCBI)pfam01212    pfam02347   
Conserved Domain (NCBI)GLDC
DMDM Disease mutations2731
Blocks (Seattle)GLDC
SuperfamilyP23378
Human Protein AtlasENSG00000178445
Peptide AtlasP23378
HPRD01996
IPIIPI00843789   
Protein Interaction databases
DIP (DOE-UCLA)P23378
IntAct (EBI)P23378
FunCoupENSG00000178445
BioGRIDGLDC
STRING (EMBL)GLDC
ZODIACGLDC
Ontologies - Pathways
QuickGOP23378
Ontology : AmiGOglycine dehydrogenase (decarboxylating) activity  glycine dehydrogenase (decarboxylating) activity  nucleus  mitochondrion  mitochondrion  mitochondrial matrix  plasma membrane  glycine cleavage complex  glycine catabolic process  electron carrier activity  glycine binding  lyase activity  glycine decarboxylation via glycine cleavage system  enzyme binding  pyridoxal phosphate binding  response to methylamine  protein homodimerization activity  glyoxylate metabolic process  oxidation-reduction process  pyridoxal binding  response to lipoic acid  
Ontology : EGO-EBIglycine dehydrogenase (decarboxylating) activity  glycine dehydrogenase (decarboxylating) activity  nucleus  mitochondrion  mitochondrion  mitochondrial matrix  plasma membrane  glycine cleavage complex  glycine catabolic process  electron carrier activity  glycine binding  lyase activity  glycine decarboxylation via glycine cleavage system  enzyme binding  pyridoxal phosphate binding  response to methylamine  protein homodimerization activity  glyoxylate metabolic process  oxidation-reduction process  pyridoxal binding  response to lipoic acid  
Pathways : KEGGGlycine, serine and threonine metabolism   
NDEx NetworkGLDC
Atlas of Cancer Signalling NetworkGLDC
Wikipedia pathwaysGLDC
Orthology - Evolution
OrthoDB2731
GeneTree (enSembl)ENSG00000178445
Phylogenetic Trees/Animal Genes : TreeFamGLDC
HOVERGENP23378
HOGENOMP23378
Homologs : HomoloGeneGLDC
Homology/Alignments : Family Browser (UCSC)GLDC
Gene fusions - Rearrangements
Fusion : MitelmanJAK2/GLDC [9p24.1/9p24.1]  [t(9;9)(p24;p24)]  
Fusion : MitelmanRFX3/GLDC [9p24.2/9p24.1]  [t(9;9)(p24;p24)]  
Fusion: TCGAJAK2 9p24.1 GLDC 9p24.1 HNSC
Fusion: TCGARFX3 9p24.2 GLDC 9p24.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLDC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLDC
dbVarGLDC
ClinVarGLDC
1000_GenomesGLDC 
Exome Variant ServerGLDC
ExAC (Exome Aggregation Consortium)GLDC (select the gene name)
Genetic variants : HAPMAP2731
Genomic Variants (DGV)GLDC [DGVbeta]
DECIPHERGLDC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLDC 
Mutations
ICGC Data PortalGLDC 
TCGA Data PortalGLDC 
Broad Tumor PortalGLDC
OASIS PortalGLDC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLDC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLDC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GLDC
DgiDB (Drug Gene Interaction Database)GLDC
DoCM (Curated mutations)GLDC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLDC (select a term)
intoGenGLDC
Cancer3DGLDC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM238300    605899   
Orphanet20768    20766    20767   
MedgenGLDC
Genetic Testing Registry GLDC
NextProtP23378 [Medical]
TSGene2731
GENETestsGLDC
Target ValidationGLDC
Huge Navigator GLDC [HugePedia]
snp3D : Map Gene to Disease2731
BioCentury BCIQGLDC
ClinGenGLDC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2731
Chemical/Pharm GKB GenePA28716
Clinical trialGLDC
Miscellaneous
canSAR (ICR)GLDC (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLDC
EVEXGLDC
GoPubMedGLDC
iHOPGLDC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:35:20 CEST 2017

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