Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GLI3 (GLI family zinc finger 3)

Identity

Other namesACLS
GCPS
GLI3-190
GLI3FL
PAP-A
PAPA
PAPA1
PAPB
PHS
PPDIV
HGNC (Hugo) GLI3
LocusID (NCBI) 2737
Location 7p14.1
Location_base_pair Starts at 42000548 and ends at 42276618 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GLI3   4319
Entrez_Gene (NCBI)GLI3  2737  GLI family zinc finger 3
Cards
GeneCards (Weizmann)GLI3
Ensembl (Hinxton)ENSG00000106571 [Gene_View]  chr7:42000548-42276618 [Contig_View]  GLI3 [Vega]
AceView (NCBI)GLI3
Genatlas (Paris)GLI3
SOURCE (Stanford)NM_000168
Genomic and cartography
GoldenPath (UCSC)GLI3  -  7p14.1   chr7:42000548-42276618 -  7p14.1   [Description]    (hg19-Feb_2009)
EnsemblGLI3 - 7p14.1 [CytoView]
Mapping of homologs : NCBIGLI3 [Mapview]
OMIM146510   165240   174200   174700   175700   200990   241800   
Gene and transcription
Genbank (Entrez)AA330409 AI863961 AK299299 AK308429 BC113616
RefSeq transcript (SRS)NM_000168
RefSeq transcript (Entrez)NM_000168
RefSeq genomic (SRS)AC_000068 AC_000139 NC_000007 NC_018918 NG_008434 NT_007819 NT_079592 NW_001839004 NW_004078029
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NC_018918 NG_008434 NT_007819 NT_079592 NW_001839004 NW_004078029
Consensus coding sequences : CCDS (NCBI)GLI3
Cluster EST : UnigeneHs.21509 [ SRS ] Hs.21509 [ NCBI ]
CGAP (NCI)Hs.21509
Alternative Splicing : Fast-db (Paris)GSHG0028141
Alternative Splicing GalleryENSG00000106571
Gene ExpressionGLI3 [ NCBI-GEO ]   GLI3 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10071 (SRS) P10071 (Uniprot)
NextProtP10071
With graphics : InterProP10071
Splice isoforms : SwissVarP10071(Swissvar)
Domaine pattern : Prosite (SRS)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (SRS)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Related proteins : CluSTrP10071
Domain families : Pfam (SRS)zf-C2H2 (PF00096)   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
DMDM2737
Blocks (Seattle)P10071
Human Protein AtlasENSG00000106571
HPRD01313
IPIIPI00018889   IPI00925202   IPI00925084   
Protein Interaction databases
DIP (DOE-UCLA)P10071
IntAct (EBI)P10071
FunCoupENSG00000106571
REACTOMEGLI3
Protein Interaction Database2737
BioGRIDGLI3
InParanoidP10071
Interologous Interaction database P10071
IntegromeDBGLI3
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GLI3
SNP (GeneSNP Utah)GLI3
SNP : HGBaseGLI3
Genetic variants : HAPMAPGLI3
Somatic Mutations in Cancer : COSMICGLI3 
CONAN: Copy Number AnalysisGLI3 
Mutations and Diseases : HGMDGLI3
OMIM146510    165240    174200    174700    175700    200990    241800   
GENETests146510    165240    174200    174700    175700    200990    241800   
Disease Genetic AssociationGLI3
Huge Navigator GLI3 [HugePedia]  GLI3 [HugeCancerGEM]
Genomic VariantsGLI3  GLI3 [DGVbeta]
snp3D : Map Gene to Disease2737
General knowledge
Homologs : HomoloGeneGLI3
Homology/Alignments : Family Browser (UCSC)GLI3
Phylogenetic Trees/Animal Genes : TreeFamGLI3
Chemical/Protein Interactions : CTD2737
Chemical/Pharm GKB GenePA28722
Clinical trialGLI3
Cancer Resource (Charite)ENSG00000106571
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  metanephros development  branching involved in ureteric bud morphogenesis  in utero embryonic development  positive regulation of neuroblast proliferation  chromatin binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nucleolus  nucleolus  cytoplasm  cytosol  cilium  transcription, DNA-dependent  smoothened signaling pathway  axon guidance  hindgut morphogenesis  heart development  beta-catenin binding  zinc ion binding  negative regulation of cell proliferation  anterior/posterior pattern specification  proximal/distal pattern formation  protein processing  mediator complex  transcriptional repressor complex  optic nerve morphogenesis  smoothened signaling pathway involved in ventral spinal cord interneuron specification  smoothened signaling pathway involved in spinal cord motor neuron cell fate specification  forebrain dorsal/ventral pattern formation  cerebral cortex radial glia guided migration  forebrain radial glial cell differentiation  lateral ganglionic eminence cell proliferation  melanocyte differentiation  lung development  positive regulation of chondrocyte differentiation  T cell differentiation in thymus  histone acetyltransferase binding  limb morphogenesis  positive regulation of protein import into nucleus  odontogenesis of dentin-containing tooth  embryonic digit morphogenesis  histone deacetylase binding  negative regulation of apoptotic process  intracellular membrane-bounded organelle  sequence-specific DNA binding  nose morphogenesis  tongue development  negative thymic T cell selection  negative regulation of neuron differentiation  positive regulation of osteoblast differentiation  negative regulation of smoothened signaling pathway  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of alpha-beta T cell differentiation  negative regulation of alpha-beta T cell differentiation  metal ion binding  embryonic digestive tract morphogenesis  embryonic digestive tract development  developmental growth  camera-type eye morphogenesis  embryonic skeletal system morphogenesis  oligodendrocyte differentiation  palate development  frontal suture morphogenesis  lambdoid suture morphogenesis  sagittal suture morphogenesis  mammary gland specification  smoothened signaling pathway involved in dorsal/ventral neural tube patterning  artery development  anterior semicircular canal development  lateral semicircular canal development  cell differentiation involved in kidney development  thymocyte apoptotic process  negative regulation of canonical Wnt receptor signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  metanephros development  branching involved in ureteric bud morphogenesis  in utero embryonic development  positive regulation of neuroblast proliferation  chromatin binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nucleolus  nucleolus  cytoplasm  cytosol  cilium  transcription, DNA-dependent  smoothened signaling pathway  axon guidance  hindgut morphogenesis  heart development  beta-catenin binding  zinc ion binding  negative regulation of cell proliferation  anterior/posterior pattern specification  proximal/distal pattern formation  protein processing  mediator complex  transcriptional repressor complex  optic nerve morphogenesis  smoothened signaling pathway involved in ventral spinal cord interneuron specification  smoothened signaling pathway involved in spinal cord motor neuron cell fate specification  forebrain dorsal/ventral pattern formation  cerebral cortex radial glia guided migration  forebrain radial glial cell differentiation  lateral ganglionic eminence cell proliferation  melanocyte differentiation  lung development  positive regulation of chondrocyte differentiation  T cell differentiation in thymus  histone acetyltransferase binding  limb morphogenesis  positive regulation of protein import into nucleus  odontogenesis of dentin-containing tooth  embryonic digit morphogenesis  histone deacetylase binding  negative regulation of apoptotic process  intracellular membrane-bounded organelle  sequence-specific DNA binding  nose morphogenesis  tongue development  negative thymic T cell selection  negative regulation of neuron differentiation  positive regulation of osteoblast differentiation  negative regulation of smoothened signaling pathway  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of alpha-beta T cell differentiation  negative regulation of alpha-beta T cell differentiation  metal ion binding  embryonic digestive tract morphogenesis  embryonic digestive tract development  developmental growth  camera-type eye morphogenesis  embryonic skeletal system morphogenesis  oligodendrocyte differentiation  palate development  frontal suture morphogenesis  lambdoid suture morphogenesis  sagittal suture morphogenesis  mammary gland specification  smoothened signaling pathway involved in dorsal/ventral neural tube patterning  artery development  anterior semicircular canal development  lateral semicircular canal development  cell differentiation involved in kidney development  thymocyte apoptotic process  negative regulation of canonical Wnt receptor signaling pathway  
Pathways : BIOCARTASonic Hedgehog (Shh) Pathway [Genes]   
Pathways : KEGGHedgehog signaling pathway
Other databases
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
PubGeneGLI3
iHOPGLI3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:23:20 CEST 2013

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