| Nomenclature | | HGNC (Hugo) | GLI3 4319 |
| Entrez_Gene (NCBI) | GLI3 2737 GLI family zinc finger 3 |
| Cards | | GeneCards (Weizmann) | GLI3 |
| Ensembl (Hinxton) | ENSG00000106571 [Gene_View] chr7:42000548-42276618 [Contig_View] GLI3 [Vega] |
| AceView (NCBI) | GLI3 |
| Genatlas (Paris) | GLI3 |
| SOURCE (Stanford) | NM_000168 |
| Genomic and cartography | | GoldenPath (UCSC) | GLI3 - 7p14.1 chr7:42000548-42276618 - 7p14.1 [Description] (hg19-Feb_2009) |
| Ensembl | GLI3 - 7p14.1 [CytoView] |
| Mapping of homologs : NCBI | GLI3 [Mapview] |
| OMIM | 146510 165240 174200 174700 175700 200990 241800 |
| Gene and transcription |
| Genbank (Entrez) | AA330409 AI863961 AK299299 AK308429 BC113616 |
| RefSeq transcript (SRS) | NM_000168 |
| RefSeq transcript (Entrez) | NM_000168 |
| RefSeq genomic (SRS) | AC_000068 AC_000139 NC_000007 NC_018918 NG_008434 NT_007819 NT_079592 NW_001839004 NW_004078029 |
| RefSeq genomic (Entrez) | AC_000068 AC_000139 NC_000007 NC_018918 NG_008434 NT_007819 NT_079592 NW_001839004 NW_004078029 |
| Consensus coding sequences : CCDS (NCBI) | GLI3 |
| Cluster EST : Unigene | Hs.21509 [ SRS ] Hs.21509 [ NCBI ] |
| CGAP (NCI) | Hs.21509 |
| Alternative Splicing : Fast-db (Paris) | GSHG0028141 |
| Alternative Splicing Gallery | ENSG00000106571 |
| Gene Expression | GLI3 [ NCBI-GEO ] GLI3 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P10071 (SRS) P10071 (Uniprot) |
| NextProt | P10071 |
| With graphics : InterPro | P10071 |
| Splice isoforms : SwissVar | P10071(Swissvar) |
| Domaine pattern : Prosite (SRS) | ZINC_FINGER_C2H2_1 (PS00028) ZINC_FINGER_C2H2_2 (PS50157) |
| Domaine pattern : Prosite (Expaxy) | ZINC_FINGER_C2H2_1 (PS00028) ZINC_FINGER_C2H2_2 (PS50157) |
| Domains : Interpro (SRS) | Znf_C2H2 Znf_C2H2-like Znf_C2H2/integrase_DNA-bd |
| Domains : Interpro (EBI) | Znf_C2H2 Znf_C2H2-like Znf_C2H2/integrase_DNA-bd |
| Related proteins : CluSTr | P10071 |
| Domain families : Pfam (SRS) | zf-C2H2 (PF00096) |
| Domain families : Pfam (Sanger) | zf-C2H2 (PF00096) |
| Domain families : Pfam (NCBI) | pfam00096 |
| Domain families : Smart (EMBL) | ZnF_C2H2 (SM00355) |
| DMDM | 2737 |
| Blocks (Seattle) | P10071 |
| Human Protein Atlas | ENSG00000106571 |
| HPRD | 01313 |
| IPI | IPI00018889 IPI00925202 IPI00925084 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P10071 |
| IntAct (EBI) | P10071 |
| FunCoup | ENSG00000106571 |
| REACTOME | GLI3 |
| Protein Interaction Database | 2737 |
| BioGRID | GLI3 |
| InParanoid | P10071 |
| Interologous Interaction database | P10071 |
| IntegromeDB | GLI3 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | GLI3 |
| SNP (GeneSNP Utah) | GLI3 |
| SNP : HGBase | GLI3 |
| Genetic variants : HAPMAP | GLI3 |
| Somatic Mutations in Cancer : COSMIC | GLI3 |
| CONAN: Copy Number Analysis | GLI3 |
| Mutations and Diseases : HGMD | GLI3 |
| OMIM | 146510 165240 174200 174700 175700 200990 241800 |
| GENETests | 146510 165240 174200 174700 175700 200990 241800 |
| Disease Genetic Association | GLI3 |
| Huge Navigator |
GLI3 [HugePedia] GLI3 [HugeCancerGEM] |
| Genomic Variants | GLI3 GLI3 [DGVbeta] |
| snp3D : Map Gene to Disease | 2737 |
| General knowledge |
|---|
| Homologs : HomoloGene | GLI3 |
| Homology/Alignments : Family Browser (UCSC) | GLI3 |
| Phylogenetic Trees/Animal Genes : TreeFam | GLI3 |
| Chemical/Protein Interactions : CTD | 2737 |
| Chemical/Pharm GKB Gene | PA28722 |
| Clinical trial | GLI3 |
| Cancer Resource (Charite) | ENSG00000106571 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter metanephros development branching involved in ureteric bud morphogenesis in utero embryonic development positive regulation of neuroblast proliferation chromatin binding sequence-specific DNA binding transcription factor activity protein binding nucleus nucleolus nucleolus cytoplasm cytosol cilium transcription, DNA-dependent smoothened signaling pathway axon guidance hindgut morphogenesis heart development beta-catenin binding zinc ion binding negative regulation of cell proliferation anterior/posterior pattern specification proximal/distal pattern formation protein processing mediator complex transcriptional repressor complex optic nerve morphogenesis smoothened signaling pathway involved in ventral spinal cord interneuron specification smoothened signaling pathway involved in spinal cord motor neuron cell fate specification forebrain dorsal/ventral pattern formation cerebral cortex radial glia guided migration forebrain radial glial cell differentiation lateral ganglionic eminence cell proliferation melanocyte differentiation lung development positive regulation of chondrocyte differentiation T cell differentiation in thymus histone acetyltransferase binding limb morphogenesis positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth embryonic digit morphogenesis histone deacetylase binding negative regulation of apoptotic process intracellular membrane-bounded organelle sequence-specific DNA binding nose morphogenesis tongue development negative thymic T cell selection negative regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-dependent positive regulation of transcription, DNA-dependent positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation metal ion binding embryonic digestive tract morphogenesis embryonic digestive tract development developmental growth camera-type eye morphogenesis embryonic skeletal system morphogenesis oligodendrocyte differentiation palate development frontal suture morphogenesis lambdoid suture morphogenesis sagittal suture morphogenesis mammary gland specification smoothened signaling pathway involved in dorsal/ventral neural tube patterning artery development anterior semicircular canal development lateral semicircular canal development cell differentiation involved in kidney development thymocyte apoptotic process negative regulation of canonical Wnt receptor signaling pathway |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter metanephros development branching involved in ureteric bud morphogenesis in utero embryonic development positive regulation of neuroblast proliferation chromatin binding sequence-specific DNA binding transcription factor activity protein binding nucleus nucleolus nucleolus cytoplasm cytosol cilium transcription, DNA-dependent smoothened signaling pathway axon guidance hindgut morphogenesis heart development beta-catenin binding zinc ion binding negative regulation of cell proliferation anterior/posterior pattern specification proximal/distal pattern formation protein processing mediator complex transcriptional repressor complex optic nerve morphogenesis smoothened signaling pathway involved in ventral spinal cord interneuron specification smoothened signaling pathway involved in spinal cord motor neuron cell fate specification forebrain dorsal/ventral pattern formation cerebral cortex radial glia guided migration forebrain radial glial cell differentiation lateral ganglionic eminence cell proliferation melanocyte differentiation lung development positive regulation of chondrocyte differentiation T cell differentiation in thymus histone acetyltransferase binding limb morphogenesis positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth embryonic digit morphogenesis histone deacetylase binding negative regulation of apoptotic process intracellular membrane-bounded organelle sequence-specific DNA binding nose morphogenesis tongue development negative thymic T cell selection negative regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-dependent positive regulation of transcription, DNA-dependent positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation metal ion binding embryonic digestive tract morphogenesis embryonic digestive tract development developmental growth camera-type eye morphogenesis embryonic skeletal system morphogenesis oligodendrocyte differentiation palate development frontal suture morphogenesis lambdoid suture morphogenesis sagittal suture morphogenesis mammary gland specification smoothened signaling pathway involved in dorsal/ventral neural tube patterning artery development anterior semicircular canal development lateral semicircular canal development cell differentiation involved in kidney development thymocyte apoptotic process negative regulation of canonical Wnt receptor signaling pathway |
| Pathways : BIOCARTA | Sonic Hedgehog (Shh) Pathway [Genes] |
| Pathways : KEGG | Hedgehog signaling pathway |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 89 Pubmed reference(s) in Entrez |
| PubGene | GLI3 |
| iHOP | GLI3 |
