Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GLRA1 (glycine receptor alpha 1)

Identity

Alias_namesSTHE
glycine receptor
Other aliasHKPX1
HGNC (Hugo) GLRA1
LocusID (NCBI) 2741
Atlas_Id 56133
Location 5q33.1  [Link to chromosome band 5q33]
Location_base_pair Starts at 151822513 and ends at 151924836 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
G3BP1 (5q33.1) / GLRA1 (5q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLRA1   4326
Cards
Entrez_Gene (NCBI)GLRA1  2741  glycine receptor alpha 1
AliasesHKPX1; STHE
GeneCards (Weizmann)GLRA1
Ensembl hg19 (Hinxton)ENSG00000145888 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145888 [Gene_View]  chr5:151822513-151924836 [Contig_View]  GLRA1 [Vega]
ICGC DataPortalENSG00000145888
TCGA cBioPortalGLRA1
AceView (NCBI)GLRA1
Genatlas (Paris)GLRA1
WikiGenes2741
SOURCE (Princeton)GLRA1
Genetics Home Reference (NIH)GLRA1
Genomic and cartography
GoldenPath hg38 (UCSC)GLRA1  -     chr5:151822513-151924836 -  5q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLRA1  -     5q33.1   [Description]    (hg19-Feb_2009)
EnsemblGLRA1 - 5q33.1 [CytoView hg19]  GLRA1 - 5q33.1 [CytoView hg38]
Mapping of homologs : NCBIGLRA1 [Mapview hg19]  GLRA1 [Mapview hg38]
OMIM138491   149400   
Gene and transcription
Genbank (Entrez)AK226046 AK308539 AK312702 BC074980 BC114947
RefSeq transcript (Entrez)NM_000171 NM_001146040 NM_001292000
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLRA1
Cluster EST : UnigeneHs.121490 [ NCBI ]
CGAP (NCI)Hs.121490
Alternative Splicing GalleryENSG00000145888
Gene ExpressionGLRA1 [ NCBI-GEO ]   GLRA1 [ EBI - ARRAY_EXPRESS ]   GLRA1 [ SEEK ]   GLRA1 [ MEM ]
Gene Expression Viewer (FireBrowse)GLRA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2741
GTEX Portal (Tissue expression)GLRA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23415   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23415  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23415
Splice isoforms : SwissVarP23415
PhosPhoSitePlusP23415
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)GABAA/Glycine_rcpt    Glycine_rcpt_A    Glycine_rcpt_A1    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)GLRA1
DMDM Disease mutations2741
Blocks (Seattle)GLRA1
PDB (SRS)1MOT    1VRY    2M6B    2M6I    4X5T   
PDB (PDBSum)1MOT    1VRY    2M6B    2M6I    4X5T   
PDB (IMB)1MOT    1VRY    2M6B    2M6I    4X5T   
PDB (RSDB)1MOT    1VRY    2M6B    2M6I    4X5T   
Structural Biology KnowledgeBase1MOT    1VRY    2M6B    2M6I    4X5T   
SCOP (Structural Classification of Proteins)1MOT    1VRY    2M6B    2M6I    4X5T   
CATH (Classification of proteins structures)1MOT    1VRY    2M6B    2M6I    4X5T   
SuperfamilyP23415
Human Protein AtlasENSG00000145888
Peptide AtlasP23415
HPRD00719
IPIIPI00795343   IPI00011565   IPI01014809   IPI00816763   IPI00974074   
Protein Interaction databases
DIP (DOE-UCLA)P23415
IntAct (EBI)P23415
FunCoupENSG00000145888
BioGRIDGLRA1
STRING (EMBL)GLRA1
ZODIACGLRA1
Ontologies - Pathways
QuickGOP23415
Ontology : AmiGOaction potential  startle response  regulation of respiratory gaseous exchange by neurological system process  protein binding  endoplasmic reticulum  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  ion transport  chloride transport  muscle contraction  neuropeptide signaling pathway  acrosome reaction  visual perception  adult walking behavior  zinc ion binding  external side of plasma membrane  integral component of membrane  glycine binding  extracellular-glycine-gated chloride channel activity  extracellular-glycine-gated chloride channel activity  extracellular-glycine-gated chloride channel activity  transmitter-gated ion channel activity  cell junction  dendrite  taurine binding  ion transmembrane transport  chloride channel complex  regulation of membrane potential  neuron projection  neuronal cell body  perikaryon  intracellular membrane-bounded organelle  synapse  postsynaptic membrane  neuromuscular process controlling posture  protein homooligomerization  protein heterooligomerization  negative regulation of transmission of nerve impulse  synaptic transmission, glycinergic  synaptic transmission, glycinergic  righting reflex  inhibitory synapse  excitatory postsynaptic potential  inhibitory postsynaptic potential  cellular response to amino acid stimulus  cellular response to zinc ion  cellular response to ethanol  response to alcohol  chloride transmembrane transport  positive regulation of acrosome reaction  
Ontology : EGO-EBIaction potential  startle response  regulation of respiratory gaseous exchange by neurological system process  protein binding  endoplasmic reticulum  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  ion transport  chloride transport  muscle contraction  neuropeptide signaling pathway  acrosome reaction  visual perception  adult walking behavior  zinc ion binding  external side of plasma membrane  integral component of membrane  glycine binding  extracellular-glycine-gated chloride channel activity  extracellular-glycine-gated chloride channel activity  extracellular-glycine-gated chloride channel activity  transmitter-gated ion channel activity  cell junction  dendrite  taurine binding  ion transmembrane transport  chloride channel complex  regulation of membrane potential  neuron projection  neuronal cell body  perikaryon  intracellular membrane-bounded organelle  synapse  postsynaptic membrane  neuromuscular process controlling posture  protein homooligomerization  protein heterooligomerization  negative regulation of transmission of nerve impulse  synaptic transmission, glycinergic  synaptic transmission, glycinergic  righting reflex  inhibitory synapse  excitatory postsynaptic potential  inhibitory postsynaptic potential  cellular response to amino acid stimulus  cellular response to zinc ion  cellular response to ethanol  response to alcohol  chloride transmembrane transport  positive regulation of acrosome reaction  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkGLRA1
Atlas of Cancer Signalling NetworkGLRA1
Wikipedia pathwaysGLRA1
Orthology - Evolution
OrthoDB2741
GeneTree (enSembl)ENSG00000145888
Phylogenetic Trees/Animal Genes : TreeFamGLRA1
HOVERGENP23415
HOGENOMP23415
Homologs : HomoloGeneGLRA1
Homology/Alignments : Family Browser (UCSC)GLRA1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLRA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLRA1
dbVarGLRA1
ClinVarGLRA1
1000_GenomesGLRA1 
Exome Variant ServerGLRA1
ExAC (Exome Aggregation Consortium)GLRA1 (select the gene name)
Genetic variants : HAPMAP2741
Genomic Variants (DGV)GLRA1 [DGVbeta]
DECIPHERGLRA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLRA1 
Mutations
ICGC Data PortalGLRA1 
TCGA Data PortalGLRA1 
Broad Tumor PortalGLRA1
OASIS PortalGLRA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLRA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLRA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch GLRA1
DgiDB (Drug Gene Interaction Database)GLRA1
DoCM (Curated mutations)GLRA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLRA1 (select a term)
intoGenGLRA1
Cancer3DGLRA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138491    149400   
Orphanet2862   
MedgenGLRA1
Genetic Testing Registry GLRA1
NextProtP23415 [Medical]
TSGene2741
GENETestsGLRA1
Huge Navigator GLRA1 [HugePedia]
snp3D : Map Gene to Disease2741
BioCentury BCIQGLRA1
ClinGenGLRA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2741
Chemical/Pharm GKB GenePA28727
Clinical trialGLRA1
Miscellaneous
canSAR (ICR)GLRA1 (select the gene name)
Probes
Litterature
PubMed126 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLRA1
EVEXGLRA1
GoPubMedGLRA1
iHOPGLRA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:17:23 CEST 2017

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