GLRA3 (glycine receptor alpha 3)

2014-11-01  

Identity

HGNC
LOCATION
4q34.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 8001
MIM: 600421
HGNC: 4328
Ensembl: ENSG00000145451

Variants:

dbSNP: 8001
ClinVar: 8001
TCGA: ENSG00000145451
COSMIC: GLRA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145451ENST00000274093O75311
ENSG00000145451ENST00000340217O75311

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ligand-gated ion channel transportREACTOMER-HSA-975298

References

Pubmed IDYearTitleCitations
264167292015Crystal structure of human glycine receptor-α3 bound to antagonist strychnine.68
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
279919022017Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.21
199594652010Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting.17
288834372017Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.15
238345092013Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.14
196610672009Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure.13
273820602016Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.4
114963712001Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies.3
78941761994Genetic mapping of the glycine receptor alpha 3 subunit on mouse chromosome 8.2

Citation

Dessen P

GLRA3 (glycine receptor alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63826/glra3