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GLRA4 (glycine receptor alpha 4)

Identity

Other alias-
HGNC (Hugo) GLRA4
LocusID (NCBI) 441509
Atlas_Id 63827
Location Xq22.2  [Link to chromosome band Xq22]
Location_base_pair Starts at 103707344 and ends at 103728624 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MORF4L2 (Xq22.2) / GLRA4 (Xq22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLRA4   31715
Cards
Entrez_Gene (NCBI)GLRA4  441509  glycine receptor alpha 4
Aliases
GeneCards (Weizmann)GLRA4
Ensembl hg19 (Hinxton)ENSG00000188828 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188828 [Gene_View]  chrX:103707344-103728624 [Contig_View]  GLRA4 [Vega]
ICGC DataPortalENSG00000188828
TCGA cBioPortalGLRA4
AceView (NCBI)GLRA4
Genatlas (Paris)GLRA4
WikiGenes441509
SOURCE (Princeton)GLRA4
Genetics Home Reference (NIH)GLRA4
Genomic and cartography
GoldenPath hg38 (UCSC)GLRA4  -     chrX:103707344-103728624 -  Xq22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLRA4  -     Xq22.2   [Description]    (hg19-Feb_2009)
EnsemblGLRA4 - Xq22.2 [CytoView hg19]  GLRA4 - Xq22.2 [CytoView hg38]
Mapping of homologs : NCBIGLRA4 [Mapview hg19]  GLRA4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK309010
RefSeq transcript (Entrez)NM_001024452 NM_001172285
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLRA4
Cluster EST : UnigeneHs.533289 [ NCBI ]
CGAP (NCI)Hs.533289
Alternative Splicing GalleryENSG00000188828
Gene ExpressionGLRA4 [ NCBI-GEO ]   GLRA4 [ EBI - ARRAY_EXPRESS ]   GLRA4 [ SEEK ]   GLRA4 [ MEM ]
Gene Expression Viewer (FireBrowse)GLRA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)441509
GTEX Portal (Tissue expression)GLRA4
Human Protein AtlasENSG00000188828-GLRA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5JXX5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5JXX5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5JXX5
Splice isoforms : SwissVarQ5JXX5
PhosPhoSitePlusQ5JXX5
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)GABAA/Glycine_rcpt    Glycine_rcpt_A    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)GLRA4
DMDM Disease mutations441509
Blocks (Seattle)GLRA4
SuperfamilyQ5JXX5
Human Protein Atlas [tissue]ENSG00000188828-GLRA4 [tissue]
Peptide AtlasQ5JXX5
IPIIPI00456931   IPI00956152   IPI00925406   
Protein Interaction databases
DIP (DOE-UCLA)Q5JXX5
IntAct (EBI)Q5JXX5
FunCoupENSG00000188828
BioGRIDGLRA4
STRING (EMBL)GLRA4
ZODIACGLRA4
Ontologies - Pathways
QuickGOQ5JXX5
Ontology : AmiGOintegral component of plasma membrane  neuropeptide signaling pathway  glycine binding  extracellular-glycine-gated chloride channel activity  transmitter-gated ion channel activity  cell junction  dendrite  chloride channel complex  response to amino acid  perikaryon  postsynaptic membrane  synaptic transmission, glycinergic  excitatory postsynaptic potential  chloride transmembrane transport  
Ontology : EGO-EBIintegral component of plasma membrane  neuropeptide signaling pathway  glycine binding  extracellular-glycine-gated chloride channel activity  transmitter-gated ion channel activity  cell junction  dendrite  chloride channel complex  response to amino acid  perikaryon  postsynaptic membrane  synaptic transmission, glycinergic  excitatory postsynaptic potential  chloride transmembrane transport  
NDEx NetworkGLRA4
Atlas of Cancer Signalling NetworkGLRA4
Wikipedia pathwaysGLRA4
Orthology - Evolution
OrthoDB441509
GeneTree (enSembl)ENSG00000188828
Phylogenetic Trees/Animal Genes : TreeFamGLRA4
HOVERGENQ5JXX5
HOGENOMQ5JXX5
Homologs : HomoloGeneGLRA4
Homology/Alignments : Family Browser (UCSC)GLRA4
Gene fusions - Rearrangements
Tumor Fusion PortalGLRA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLRA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLRA4
dbVarGLRA4
ClinVarGLRA4
1000_GenomesGLRA4 
Exome Variant ServerGLRA4
ExAC (Exome Aggregation Consortium)ENSG00000188828
GNOMAD BrowserENSG00000188828
Genetic variants : HAPMAP441509
Genomic Variants (DGV)GLRA4 [DGVbeta]
DECIPHERGLRA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLRA4 
Mutations
ICGC Data PortalGLRA4 
TCGA Data PortalGLRA4 
Broad Tumor PortalGLRA4
OASIS PortalGLRA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLRA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLRA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch GLRA4
DgiDB (Drug Gene Interaction Database)GLRA4
DoCM (Curated mutations)GLRA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLRA4 (select a term)
intoGenGLRA4
Cancer3DGLRA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETGLRA4
MedgenGLRA4
Genetic Testing Registry GLRA4
NextProtQ5JXX5 [Medical]
TSGene441509
GENETestsGLRA4
Target ValidationGLRA4
Huge Navigator GLRA4 [HugePedia]
snp3D : Map Gene to Disease441509
BioCentury BCIQGLRA4
ClinGenGLRA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD441509
Chemical/Pharm GKB GenePA142671731
Clinical trialGLRA4
Miscellaneous
canSAR (ICR)GLRA4 (select the gene name)
Probes
Litterature
PubMed3 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLRA4
EVEXGLRA4
GoPubMedGLRA4
iHOPGLRA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Nov 20 19:31:17 CET 2017

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