Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GLRB (glycine receptor beta)

Identity

Other aliasHKPX2
HGNC (Hugo) GLRB
LocusID (NCBI) 2743
Atlas_Id 63828
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 157076125 and ends at 157172090 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GLRB (4q32.1) / LRBA (4q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLRB   4329
Cards
Entrez_Gene (NCBI)GLRB  2743  glycine receptor beta
AliasesHKPX2
GeneCards (Weizmann)GLRB
Ensembl hg19 (Hinxton)ENSG00000109738 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109738 [Gene_View]  chr4:157076125-157172090 [Contig_View]  GLRB [Vega]
ICGC DataPortalENSG00000109738
TCGA cBioPortalGLRB
AceView (NCBI)GLRB
Genatlas (Paris)GLRB
WikiGenes2743
SOURCE (Princeton)GLRB
Genetics Home Reference (NIH)GLRB
Genomic and cartography
GoldenPath hg38 (UCSC)GLRB  -     chr4:157076125-157172090 +  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLRB  -     4q32.1   [Description]    (hg19-Feb_2009)
EnsemblGLRB - 4q32.1 [CytoView hg19]  GLRB - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBIGLRB [Mapview hg19]  GLRB [Mapview hg38]
OMIM138492   614619   
Gene and transcription
Genbank (Entrez)AF094754 AF094755 AK290617 BC022502 BC032635
RefSeq transcript (Entrez)NM_000824 NM_001166060 NM_001166061
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLRB
Cluster EST : UnigeneHs.32973 [ NCBI ]
CGAP (NCI)Hs.32973
Alternative Splicing GalleryENSG00000109738
Gene ExpressionGLRB [ NCBI-GEO ]   GLRB [ EBI - ARRAY_EXPRESS ]   GLRB [ SEEK ]   GLRB [ MEM ]
Gene Expression Viewer (FireBrowse)GLRB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2743
GTEX Portal (Tissue expression)GLRB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48167   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48167  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48167
Splice isoforms : SwissVarP48167
PhosPhoSitePlusP48167
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Glycine_rcpt_B    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)GLRB
DMDM Disease mutations2743
Blocks (Seattle)GLRB
SuperfamilyP48167
Human Protein AtlasENSG00000109738
Peptide AtlasP48167
HPRD11751
IPIIPI00008224   IPI00945266   IPI00966816   IPI00967134   
Protein Interaction databases
DIP (DOE-UCLA)P48167
IntAct (EBI)P48167
FunCoupENSG00000109738
BioGRIDGLRB
STRING (EMBL)GLRB
ZODIACGLRB
Ontologies - Pathways
QuickGOP48167
Ontology : AmiGOstartle response  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  ion transport  neuropeptide signaling pathway  chemical synaptic transmission  acrosome reaction  nervous system development  visual perception  adult walking behavior  drug binding  glycine binding  extracellular-glycine-gated ion channel activity  extracellular-glycine-gated chloride channel activity  glycine-gated chloride channel complex  cell junction  dendrite  ion transmembrane transport  response to amino acid  postsynaptic membrane  protein heterooligomerization  synaptic transmission, glycinergic  righting reflex  excitatory postsynaptic potential  gamma-aminobutyric acid receptor clustering  GABA-ergic synapse  chloride transmembrane transport  
Ontology : EGO-EBIstartle response  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  ion transport  neuropeptide signaling pathway  chemical synaptic transmission  acrosome reaction  nervous system development  visual perception  adult walking behavior  drug binding  glycine binding  extracellular-glycine-gated ion channel activity  extracellular-glycine-gated chloride channel activity  glycine-gated chloride channel complex  cell junction  dendrite  ion transmembrane transport  response to amino acid  postsynaptic membrane  protein heterooligomerization  synaptic transmission, glycinergic  righting reflex  excitatory postsynaptic potential  gamma-aminobutyric acid receptor clustering  GABA-ergic synapse  chloride transmembrane transport  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkGLRB
Atlas of Cancer Signalling NetworkGLRB
Wikipedia pathwaysGLRB
Orthology - Evolution
OrthoDB2743
GeneTree (enSembl)ENSG00000109738
Phylogenetic Trees/Animal Genes : TreeFamGLRB
HOVERGENP48167
HOGENOMP48167
Homologs : HomoloGeneGLRB
Homology/Alignments : Family Browser (UCSC)GLRB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLRB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLRB
dbVarGLRB
ClinVarGLRB
1000_GenomesGLRB 
Exome Variant ServerGLRB
ExAC (Exome Aggregation Consortium)GLRB (select the gene name)
Genetic variants : HAPMAP2743
Genomic Variants (DGV)GLRB [DGVbeta]
DECIPHERGLRB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLRB 
Mutations
ICGC Data PortalGLRB 
TCGA Data PortalGLRB 
Broad Tumor PortalGLRB
OASIS PortalGLRB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLRB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLRB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GLRB
DgiDB (Drug Gene Interaction Database)GLRB
DoCM (Curated mutations)GLRB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLRB (select a term)
intoGenGLRB
Cancer3DGLRB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138492    614619   
Orphanet2862   
MedgenGLRB
Genetic Testing Registry GLRB
NextProtP48167 [Medical]
TSGene2743
GENETestsGLRB
Target ValidationGLRB
Huge Navigator GLRB [HugePedia]
snp3D : Map Gene to Disease2743
BioCentury BCIQGLRB
ClinGenGLRB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2743
Chemical/Pharm GKB GenePA28730
Clinical trialGLRB
Miscellaneous
canSAR (ICR)GLRB (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLRB
EVEXGLRB
GoPubMedGLRB
iHOPGLRB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:50:45 CEST 2017

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