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GLRX (glutaredoxin)

Identity

Alias_namesglutaredoxin (thioltransferase)
Alias_symbol (synonym)GRX
GRX1
Other alias
HGNC (Hugo) GLRX
LocusID (NCBI) 2745
Atlas_Id 43676
Location 5q15  [Link to chromosome band 5q15]
Location_base_pair Starts at 95813849 and ends at 95822873 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GLRX (5q15) / GLRX (5q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLRX   4330
Cards
Entrez_Gene (NCBI)GLRX  2745  glutaredoxin
AliasesGRX; GRX1
GeneCards (Weizmann)GLRX
Ensembl hg19 (Hinxton)ENSG00000173221 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173221 [Gene_View]  chr5:95813849-95822873 [Contig_View]  GLRX [Vega]
ICGC DataPortalENSG00000173221
TCGA cBioPortalGLRX
AceView (NCBI)GLRX
Genatlas (Paris)GLRX
WikiGenes2745
SOURCE (Princeton)GLRX
Genetics Home Reference (NIH)GLRX
Genomic and cartography
GoldenPath hg38 (UCSC)GLRX  -     chr5:95813849-95822873 -  5q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLRX  -     5q15   [Description]    (hg19-Feb_2009)
EnsemblGLRX - 5q15 [CytoView hg19]  GLRX - 5q15 [CytoView hg38]
Mapping of homologs : NCBIGLRX [Mapview hg19]  GLRX [Mapview hg38]
OMIM600443   
Gene and transcription
Genbank (Entrez)AA485178 AF069668 AF162769 AK094753 AK125636
RefSeq transcript (Entrez)NM_001118890 NM_001243658 NM_001243659 NM_002064
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLRX
Cluster EST : UnigeneHs.28988 [ NCBI ]
CGAP (NCI)Hs.28988
Alternative Splicing GalleryENSG00000173221
Gene ExpressionGLRX [ NCBI-GEO ]   GLRX [ EBI - ARRAY_EXPRESS ]   GLRX [ SEEK ]   GLRX [ MEM ]
Gene Expression Viewer (FireBrowse)GLRX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2745
GTEX Portal (Tissue expression)GLRX
Human Protein AtlasENSG00000173221-GLRX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35754   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35754  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35754
Splice isoforms : SwissVarP35754
PhosPhoSitePlusP35754
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_1 (PS00195)    GLUTAREDOXIN_2 (PS51354)   
Domains : Interpro (EBI)GLR_AS    Glutaredoxin    Glutaredoxin_euk/vir    Glutaredoxin_subgr    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)Glutaredoxin (PF00462)   
Domain families : Pfam (NCBI)pfam00462   
Conserved Domain (NCBI)GLRX
DMDM Disease mutations2745
Blocks (Seattle)GLRX
PDB (SRS)1B4Q    1JHB    4RQR   
PDB (PDBSum)1B4Q    1JHB    4RQR   
PDB (IMB)1B4Q    1JHB    4RQR   
PDB (RSDB)1B4Q    1JHB    4RQR   
Structural Biology KnowledgeBase1B4Q    1JHB    4RQR   
SCOP (Structural Classification of Proteins)1B4Q    1JHB    4RQR   
CATH (Classification of proteins structures)1B4Q    1JHB    4RQR   
SuperfamilyP35754
Human Protein Atlas [tissue]ENSG00000173221-GLRX [tissue]
Peptide AtlasP35754
HPRD02707
IPIIPI00219025   IPI00160508   
Protein Interaction databases
DIP (DOE-UCLA)P35754
IntAct (EBI)P35754
FunCoupENSG00000173221
BioGRIDGLRX
STRING (EMBL)GLRX
ZODIACGLRX
Ontologies - Pathways
QuickGOP35754
Ontology : AmiGOnucleus  mitochondrion  cytosol  electron carrier activity  glutathione disulfide oxidoreductase activity  nucleobase-containing small molecule interconversion  cell redox homeostasis  positive regulation of membrane potential  protein N-terminus binding  oxidation-reduction process  extracellular exosome  protein deglutathionylation  glutathione oxidoreductase activity  positive regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBInucleus  mitochondrion  cytosol  electron carrier activity  glutathione disulfide oxidoreductase activity  nucleobase-containing small molecule interconversion  cell redox homeostasis  positive regulation of membrane potential  protein N-terminus binding  oxidation-reduction process  extracellular exosome  protein deglutathionylation  glutathione oxidoreductase activity  positive regulation of sodium ion transmembrane transporter activity  
NDEx NetworkGLRX
Atlas of Cancer Signalling NetworkGLRX
Wikipedia pathwaysGLRX
Orthology - Evolution
OrthoDB2745
GeneTree (enSembl)ENSG00000173221
Phylogenetic Trees/Animal Genes : TreeFamGLRX
HOVERGENP35754
HOGENOMP35754
Homologs : HomoloGeneGLRX
Homology/Alignments : Family Browser (UCSC)GLRX
Gene fusions - Rearrangements
Tumor Fusion PortalGLRX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLRX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLRX
dbVarGLRX
ClinVarGLRX
1000_GenomesGLRX 
Exome Variant ServerGLRX
ExAC (Exome Aggregation Consortium)ENSG00000173221
GNOMAD BrowserENSG00000173221
Genetic variants : HAPMAP2745
Genomic Variants (DGV)GLRX [DGVbeta]
DECIPHERGLRX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLRX 
Mutations
ICGC Data PortalGLRX 
TCGA Data PortalGLRX 
Broad Tumor PortalGLRX
OASIS PortalGLRX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLRX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLRX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GLRX
DgiDB (Drug Gene Interaction Database)GLRX
DoCM (Curated mutations)GLRX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLRX (select a term)
intoGenGLRX
Cancer3DGLRX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600443   
Orphanet
DisGeNETGLRX
MedgenGLRX
Genetic Testing Registry GLRX
NextProtP35754 [Medical]
TSGene2745
GENETestsGLRX
Target ValidationGLRX
Huge Navigator GLRX [HugePedia]
snp3D : Map Gene to Disease2745
BioCentury BCIQGLRX
ClinGenGLRX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2745
Chemical/Pharm GKB GenePA28731
Clinical trialGLRX
Miscellaneous
canSAR (ICR)GLRX (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLRX
EVEXGLRX
GoPubMedGLRX
iHOPGLRX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:14:45 CET 2017

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