Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GLRX2 (glutaredoxin 2)

Identity

Alias (NCBI)CGI-133
GRX2
HGNC (Hugo) GLRX2
HGNC Alias symbGRX2
bA101E13.1
HGNC Previous nameglutaredoxin (thioltransferase) 2
LocusID (NCBI) 51022
Atlas_Id 45661
Location 1q31.2  [Link to chromosome band 1q31]
Location_base_pair Starts at 193096470 and ends at 193105414 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GLRX2   16065
Cards
Entrez_Gene (NCBI)GLRX2    glutaredoxin 2
AliasesCGI-133; GRX2
GeneCards (Weizmann)GLRX2
Ensembl hg19 (Hinxton)ENSG00000023572 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000023572 [Gene_View]  ENSG00000023572 [Sequence]  chr1:193096470-193105414 [Contig_View]  GLRX2 [Vega]
ICGC DataPortalENSG00000023572
TCGA cBioPortalGLRX2
AceView (NCBI)GLRX2
Genatlas (Paris)GLRX2
SOURCE (Princeton)GLRX2
Genetics Home Reference (NIH)GLRX2
Genomic and cartography
GoldenPath hg38 (UCSC)GLRX2  -     chr1:193096470-193105414 -  1q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLRX2  -     1q31.2   [Description]    (hg19-Feb_2009)
GoldenPathGLRX2 - 1q31.2 [CytoView hg19]  GLRX2 - 1q31.2 [CytoView hg38]
ImmunoBaseENSG00000023572
Genome Data Viewer NCBIGLRX2 [Mapview hg19]  
OMIM606820   
Gene and transcription
Genbank (Entrez)AA056513 AA887118 AF132495 AF151891 AF290514
RefSeq transcript (Entrez)NM_001243399 NM_016066 NM_197962
Consensus coding sequences : CCDS (NCBI)GLRX2
Gene ExpressionGLRX2 [ NCBI-GEO ]   GLRX2 [ EBI - ARRAY_EXPRESS ]   GLRX2 [ SEEK ]   GLRX2 [ MEM ]
Gene Expression Viewer (FireBrowse)GLRX2 [ Firebrowse - Broad ]
GenevisibleExpression of GLRX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51022
GTEX Portal (Tissue expression)GLRX2
Human Protein AtlasENSG00000023572-GLRX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NS18   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NS18  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NS18
PhosPhoSitePlusQ9NS18
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_2 (PS51354)   
Domains : Interpro (EBI)Glutaredoxin    Glutaredoxin_euk/vir    Glutaredoxin_subgr    Thioredoxin-like_sf   
Domain families : Pfam (Sanger)Glutaredoxin (PF00462)   
Domain families : Pfam (NCBI)pfam00462   
Conserved Domain (NCBI)GLRX2
PDB (RSDB)2CQ9    2FLS    2HT9   
PDB Europe2CQ9    2FLS    2HT9   
PDB (PDBSum)2CQ9    2FLS    2HT9   
PDB (IMB)2CQ9    2FLS    2HT9   
Structural Biology KnowledgeBase2CQ9    2FLS    2HT9   
SCOP (Structural Classification of Proteins)2CQ9    2FLS    2HT9   
CATH (Classification of proteins structures)2CQ9    2FLS    2HT9   
SuperfamilyQ9NS18
AlphaFold pdb e-kbQ9NS18   
Human Protein Atlas [tissue]ENSG00000023572-GLRX2 [tissue]
HPRD12112
Protein Interaction databases
DIP (DOE-UCLA)Q9NS18
IntAct (EBI)Q9NS18
BioGRIDGLRX2
STRING (EMBL)GLRX2
ZODIACGLRX2
Ontologies - Pathways
QuickGOQ9NS18
Ontology : AmiGOprotein disulfide isomerase activity  protein binding  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  regulation of transcription, DNA-templated  glutathione metabolic process  apoptotic process  aging  arsenate reductase (glutaredoxin) activity  electron transfer activity  response to temperature stimulus  regulation of signal transduction  response to organic substance  glutathione disulfide oxidoreductase activity  electron transport chain  cell differentiation  dendrite  DNA protection  response to hydrogen peroxide  neuronal cell body  intracellular membrane-bounded organelle  cell redox homeostasis  metal ion binding  2 iron, 2 sulfur cluster binding  response to redox state  cellular response to superoxide  glutathione oxidoreductase activity  
Ontology : EGO-EBIprotein disulfide isomerase activity  protein binding  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  regulation of transcription, DNA-templated  glutathione metabolic process  apoptotic process  aging  arsenate reductase (glutaredoxin) activity  electron transfer activity  response to temperature stimulus  regulation of signal transduction  response to organic substance  glutathione disulfide oxidoreductase activity  electron transport chain  cell differentiation  dendrite  DNA protection  response to hydrogen peroxide  neuronal cell body  intracellular membrane-bounded organelle  cell redox homeostasis  metal ion binding  2 iron, 2 sulfur cluster binding  response to redox state  cellular response to superoxide  glutathione oxidoreductase activity  
NDEx NetworkGLRX2
Atlas of Cancer Signalling NetworkGLRX2
Wikipedia pathwaysGLRX2
Orthology - Evolution
OrthoDB51022
GeneTree (enSembl)ENSG00000023572
Phylogenetic Trees/Animal Genes : TreeFamGLRX2
Homologs : HomoloGeneGLRX2
Homology/Alignments : Family Browser (UCSC)GLRX2
Gene fusions - Rearrangements
Fusion : QuiverGLRX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLRX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLRX2
dbVarGLRX2
ClinVarGLRX2
MonarchGLRX2
1000_GenomesGLRX2 
Exome Variant ServerGLRX2
GNOMAD BrowserENSG00000023572
Varsome BrowserGLRX2
ACMGGLRX2 variants
VarityQ9NS18
Genomic Variants (DGV)GLRX2 [DGVbeta]
DECIPHERGLRX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLRX2 
Mutations
ICGC Data PortalGLRX2 
TCGA Data PortalGLRX2 
Broad Tumor PortalGLRX2
OASIS PortalGLRX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLRX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGLRX2
Mutations and Diseases : HGMDGLRX2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGLRX2
DgiDB (Drug Gene Interaction Database)GLRX2
DoCM (Curated mutations)GLRX2
CIViC (Clinical Interpretations of Variants in Cancer)GLRX2
Cancer3DGLRX2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606820   
Orphanet
DisGeNETGLRX2
MedgenGLRX2
Genetic Testing Registry GLRX2
NextProtQ9NS18 [Medical]
GENETestsGLRX2
Target ValidationGLRX2
Huge Navigator GLRX2 [HugePedia]
ClinGenGLRX2
Clinical trials, drugs, therapy
MyCancerGenomeGLRX2
Protein Interactions : CTDGLRX2
Pharm GKB GenePA28732
PharosQ9NS18
Clinical trialGLRX2
Miscellaneous
canSAR (ICR)GLRX2
HarmonizomeGLRX2
ARCHS4GLRX2
DataMed IndexGLRX2
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGLRX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:35:15 CET 2022

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