GLRX2 (glutaredoxin 2)

2007-02-01  

Identity

HGNC
LOCATION
1q31.2
LOCUSID
ALIAS
CGI-133,GRX2

Other Information

Locus ID:

NCBI: 51022
MIM: 606820
HGNC: 16065
Ensembl: ENSG00000023572

Variants:

dbSNP: 51022
ClinVar: 51022
TCGA: ENSG00000023572
COSMIC: GLRX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000023572ENST00000367439Q9NS18
ENSG00000023572ENST00000367440Q9NS18
ENSG00000023572ENST00000608166Q9NS18

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159173332005Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor.71
146762182004Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase.68
188160652008Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles.46
171218592007Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.42
209298582010Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.42
152979672004Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo.34
171158942007How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?34
151840542004Cellular and plasma levels of human glutaredoxin 1 and 2 detected by sensitive ELISA systems.27
221393722011Vertebrate-specific glutaredoxin is essential for brain development.24
214373212011Mechanism of glutaredoxin-ISU [2Fe-2S] cluster exchange.22

Citation

Dessen P

GLRX2 (glutaredoxin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45661/glrx2