Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GLRX2 (glutaredoxin 2)

Identity

Alias_namesglutaredoxin (thioltransferase) 2
Alias_symbol (synonym)GRX2
bA101E13.1
Other aliasCGI-133
HGNC (Hugo) GLRX2
LocusID (NCBI) 51022
Atlas_Id 45661
Location 1q31.2  [Link to chromosome band 1q31]
Location_base_pair Starts at 193096465 and ends at 193106057 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLRX2   16065
Cards
Entrez_Gene (NCBI)GLRX2  51022  glutaredoxin 2
AliasesCGI-133; GRX2
GeneCards (Weizmann)GLRX2
Ensembl hg19 (Hinxton)ENSG00000023572 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000023572 [Gene_View]  chr1:193096465-193106057 [Contig_View]  GLRX2 [Vega]
ICGC DataPortalENSG00000023572
TCGA cBioPortalGLRX2
AceView (NCBI)GLRX2
Genatlas (Paris)GLRX2
WikiGenes51022
SOURCE (Princeton)GLRX2
Genetics Home Reference (NIH)GLRX2
Genomic and cartography
GoldenPath hg38 (UCSC)GLRX2  -     chr1:193096465-193106057 -  1q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLRX2  -     1q31.2   [Description]    (hg19-Feb_2009)
EnsemblGLRX2 - 1q31.2 [CytoView hg19]  GLRX2 - 1q31.2 [CytoView hg38]
Mapping of homologs : NCBIGLRX2 [Mapview hg19]  GLRX2 [Mapview hg38]
OMIM606820   
Gene and transcription
Genbank (Entrez)AA056513 AA887118 AF132495 AF151891 AF290514
RefSeq transcript (Entrez)NM_001243399 NM_001319291 NM_016066 NM_197962
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLRX2
Cluster EST : UnigeneHs.458283 [ NCBI ]
CGAP (NCI)Hs.458283
Alternative Splicing GalleryENSG00000023572
Gene ExpressionGLRX2 [ NCBI-GEO ]   GLRX2 [ EBI - ARRAY_EXPRESS ]   GLRX2 [ SEEK ]   GLRX2 [ MEM ]
Gene Expression Viewer (FireBrowse)GLRX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51022
GTEX Portal (Tissue expression)GLRX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NS18   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NS18  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NS18
Splice isoforms : SwissVarQ9NS18
PhosPhoSitePlusQ9NS18
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_2 (PS51354)   
Domains : Interpro (EBI)Glutaredoxin    Glutaredoxin_euk/vir    Glutaredoxin_subgr    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)Glutaredoxin (PF00462)   
Domain families : Pfam (NCBI)pfam00462   
Conserved Domain (NCBI)GLRX2
DMDM Disease mutations51022
Blocks (Seattle)GLRX2
PDB (SRS)2CQ9    2FLS    2HT9   
PDB (PDBSum)2CQ9    2FLS    2HT9   
PDB (IMB)2CQ9    2FLS    2HT9   
PDB (RSDB)2CQ9    2FLS    2HT9   
Structural Biology KnowledgeBase2CQ9    2FLS    2HT9   
SCOP (Structural Classification of Proteins)2CQ9    2FLS    2HT9   
CATH (Classification of proteins structures)2CQ9    2FLS    2HT9   
SuperfamilyQ9NS18
Human Protein AtlasENSG00000023572
Peptide AtlasQ9NS18
HPRD12112
IPIIPI00100044   IPI00007045   
Protein Interaction databases
DIP (DOE-UCLA)Q9NS18
IntAct (EBI)Q9NS18
FunCoupENSG00000023572
BioGRIDGLRX2
STRING (EMBL)GLRX2
ZODIACGLRX2
Ontologies - Pathways
QuickGOQ9NS18
Ontology : AmiGOprotein disulfide isomerase activity  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  regulation of transcription, DNA-templated  glutathione metabolic process  apoptotic process  aging  arsenate reductase (glutaredoxin) activity  electron carrier activity  response to temperature stimulus  regulation of signal transduction  response to organic substance  protein disulfide oxidoreductase activity  glutathione disulfide oxidoreductase activity  cell differentiation  dendrite  DNA protection  response to hydrogen peroxide  neuronal cell body  intracellular membrane-bounded organelle  cell redox homeostasis  metal ion binding  2 iron, 2 sulfur cluster binding  response to redox state  oxidation-reduction process  cellular response to superoxide  
Ontology : EGO-EBIprotein disulfide isomerase activity  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  regulation of transcription, DNA-templated  glutathione metabolic process  apoptotic process  aging  arsenate reductase (glutaredoxin) activity  electron carrier activity  response to temperature stimulus  regulation of signal transduction  response to organic substance  protein disulfide oxidoreductase activity  glutathione disulfide oxidoreductase activity  cell differentiation  dendrite  DNA protection  response to hydrogen peroxide  neuronal cell body  intracellular membrane-bounded organelle  cell redox homeostasis  metal ion binding  2 iron, 2 sulfur cluster binding  response to redox state  oxidation-reduction process  cellular response to superoxide  
NDEx NetworkGLRX2
Atlas of Cancer Signalling NetworkGLRX2
Wikipedia pathwaysGLRX2
Orthology - Evolution
OrthoDB51022
GeneTree (enSembl)ENSG00000023572
Phylogenetic Trees/Animal Genes : TreeFamGLRX2
HOVERGENQ9NS18
HOGENOMQ9NS18
Homologs : HomoloGeneGLRX2
Homology/Alignments : Family Browser (UCSC)GLRX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLRX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLRX2
dbVarGLRX2
ClinVarGLRX2
1000_GenomesGLRX2 
Exome Variant ServerGLRX2
ExAC (Exome Aggregation Consortium)GLRX2 (select the gene name)
Genetic variants : HAPMAP51022
Genomic Variants (DGV)GLRX2 [DGVbeta]
DECIPHERGLRX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLRX2 
Mutations
ICGC Data PortalGLRX2 
TCGA Data PortalGLRX2 
Broad Tumor PortalGLRX2
OASIS PortalGLRX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLRX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLRX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GLRX2
DgiDB (Drug Gene Interaction Database)GLRX2
DoCM (Curated mutations)GLRX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLRX2 (select a term)
intoGenGLRX2
Cancer3DGLRX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606820   
Orphanet
MedgenGLRX2
Genetic Testing Registry GLRX2
NextProtQ9NS18 [Medical]
TSGene51022
GENETestsGLRX2
Target ValidationGLRX2
Huge Navigator GLRX2 [HugePedia]
snp3D : Map Gene to Disease51022
BioCentury BCIQGLRX2
ClinGenGLRX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51022
Chemical/Pharm GKB GenePA28732
Clinical trialGLRX2
Miscellaneous
canSAR (ICR)GLRX2 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLRX2
EVEXGLRX2
GoPubMedGLRX2
iHOPGLRX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 25 19:09:59 CEST 2017

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