Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GLRX3 (glutaredoxin 3)

Identity

Alias_namesTXNL2
thioredoxin-like 2
Alias_symbol (synonym)PICOT
bA500G10.4
GRX3
GLRX4
GRX4
Other aliasTXNL3
HGNC (Hugo) GLRX3
LocusID (NCBI) 10539
Atlas_Id 50374
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 130136375 and ends at 130180382 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GLRX3 (10q26.3) / C10orf11 (10q22.2)GLRX3 (10q26.3) / LYRM2 (6q15)HECTD2 (10q23.32) / GLRX3 (10q26.3)
GLRX3 10q26.3 / C10orf11 10q22.2HECTD2 10q23.32 / GLRX3 10q26.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLRX3   15987
Cards
Entrez_Gene (NCBI)GLRX3  10539  glutaredoxin 3
AliasesGLRX4; GRX3; GRX4; PICOT; 
TXNL2; TXNL3
GeneCards (Weizmann)GLRX3
Ensembl hg19 (Hinxton)ENSG00000108010 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108010 [Gene_View]  chr10:130136375-130180382 [Contig_View]  GLRX3 [Vega]
ICGC DataPortalENSG00000108010
TCGA cBioPortalGLRX3
AceView (NCBI)GLRX3
Genatlas (Paris)GLRX3
WikiGenes10539
SOURCE (Princeton)GLRX3
Genetics Home Reference (NIH)GLRX3
Genomic and cartography
GoldenPath hg38 (UCSC)GLRX3  -     chr10:130136375-130180382 +  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLRX3  -     10q26.3   [Description]    (hg19-Feb_2009)
EnsemblGLRX3 - 10q26.3 [CytoView hg19]  GLRX3 - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBIGLRX3 [Mapview hg19]  GLRX3 [Mapview hg38]
OMIM612754   
Gene and transcription
Genbank (Entrez)AA995117 AF118649 AF118652 AJ010841 AK022131
RefSeq transcript (Entrez)NM_001199868 NM_001321980 NM_006541
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLRX3
Cluster EST : UnigeneHs.42644 [ NCBI ]
CGAP (NCI)Hs.42644
Alternative Splicing GalleryENSG00000108010
Gene ExpressionGLRX3 [ NCBI-GEO ]   GLRX3 [ EBI - ARRAY_EXPRESS ]   GLRX3 [ SEEK ]   GLRX3 [ MEM ]
Gene Expression Viewer (FireBrowse)GLRX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10539
GTEX Portal (Tissue expression)GLRX3
Human Protein AtlasENSG00000108010-GLRX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76003   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76003  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76003
Splice isoforms : SwissVarO76003
PhosPhoSitePlusO76003
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_2 (PS51354)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Glutaredoxin    GRX_PICOT-like    Monothiol_GRX-rel    Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)Glutaredoxin (PF00462)    Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00462    pfam00085   
Conserved Domain (NCBI)GLRX3
DMDM Disease mutations10539
Blocks (Seattle)GLRX3
PDB (SRS)2DIY    2WZ9    2YAN    3ZYW   
PDB (PDBSum)2DIY    2WZ9    2YAN    3ZYW   
PDB (IMB)2DIY    2WZ9    2YAN    3ZYW   
PDB (RSDB)2DIY    2WZ9    2YAN    3ZYW   
Structural Biology KnowledgeBase2DIY    2WZ9    2YAN    3ZYW   
SCOP (Structural Classification of Proteins)2DIY    2WZ9    2YAN    3ZYW   
CATH (Classification of proteins structures)2DIY    2WZ9    2YAN    3ZYW   
SuperfamilyO76003
Human Protein Atlas [tissue]ENSG00000108010-GLRX3 [tissue]
Peptide AtlasO76003
HPRD10153
IPIIPI00008552   
Protein Interaction databases
DIP (DOE-UCLA)O76003
IntAct (EBI)O76003
FunCoupENSG00000108010
BioGRIDGLRX3
STRING (EMBL)GLRX3
ZODIACGLRX3
Ontologies - Pathways
QuickGOO76003
Ontology : AmiGOregulation of the force of heart contraction  RNA binding  protein kinase C binding  protein binding  nucleus  cytosol  cell cortex  electron carrier activity  negative regulation of cardiac muscle hypertrophy  protein disulfide oxidoreductase activity  Z disc  dendrite  [2Fe-2S] cluster assembly  cell redox homeostasis  metal ion binding  iron-sulfur cluster binding  oxidation-reduction process  extracellular exosome  protein maturation by iron-sulfur cluster transfer  
Ontology : EGO-EBIregulation of the force of heart contraction  RNA binding  protein kinase C binding  protein binding  nucleus  cytosol  cell cortex  electron carrier activity  negative regulation of cardiac muscle hypertrophy  protein disulfide oxidoreductase activity  Z disc  dendrite  [2Fe-2S] cluster assembly  cell redox homeostasis  metal ion binding  iron-sulfur cluster binding  oxidation-reduction process  extracellular exosome  protein maturation by iron-sulfur cluster transfer  
NDEx NetworkGLRX3
Atlas of Cancer Signalling NetworkGLRX3
Wikipedia pathwaysGLRX3
Orthology - Evolution
OrthoDB10539
GeneTree (enSembl)ENSG00000108010
Phylogenetic Trees/Animal Genes : TreeFamGLRX3
HOVERGENO76003
HOGENOMO76003
Homologs : HomoloGeneGLRX3
Homology/Alignments : Family Browser (UCSC)GLRX3
Gene fusions - Rearrangements
Fusion : MitelmanGLRX3/C10orf11 [10q26.3/10q22.2]  
Fusion : MitelmanHECTD2/GLRX3 [10q23.32/10q26.3]  [t(10;10)(q23;q26)]  
Fusion: TCGA_MDACCGLRX3 10q26.3 C10orf11 10q22.2 BRCA
Fusion: TCGA_MDACCHECTD2 10q23.32 GLRX3 10q26.3 BRCA
Tumor Fusion PortalGLRX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLRX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLRX3
dbVarGLRX3
ClinVarGLRX3
1000_GenomesGLRX3 
Exome Variant ServerGLRX3
ExAC (Exome Aggregation Consortium)ENSG00000108010
GNOMAD BrowserENSG00000108010
Genetic variants : HAPMAP10539
Genomic Variants (DGV)GLRX3 [DGVbeta]
DECIPHERGLRX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLRX3 
Mutations
ICGC Data PortalGLRX3 
TCGA Data PortalGLRX3 
Broad Tumor PortalGLRX3
OASIS PortalGLRX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLRX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLRX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GLRX3
DgiDB (Drug Gene Interaction Database)GLRX3
DoCM (Curated mutations)GLRX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLRX3 (select a term)
intoGenGLRX3
Cancer3DGLRX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612754   
Orphanet
DisGeNETGLRX3
MedgenGLRX3
Genetic Testing Registry GLRX3
NextProtO76003 [Medical]
TSGene10539
GENETestsGLRX3
Target ValidationGLRX3
Huge Navigator GLRX3 [HugePedia]
snp3D : Map Gene to Disease10539
BioCentury BCIQGLRX3
ClinGenGLRX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10539
Chemical/Pharm GKB GenePA162389829
Clinical trialGLRX3
Miscellaneous
canSAR (ICR)GLRX3 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLRX3
EVEXGLRX3
GoPubMedGLRX3
iHOPGLRX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:14:45 CET 2017

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