Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GLRX3 (glutaredoxin 3)

Identity

Alias (NCBI)GLRX4
GRX3
GRX4
PICOT
TXNL2
TXNL3
HGNC (Hugo) GLRX3
HGNC Alias symbPICOT
bA500G10.4
GRX3
GLRX4
GRX4
HGNC Alias nameglutaredoxin 4
HGNC Previous nameTXNL2
HGNC Previous namethioredoxin-like 2
LocusID (NCBI) 10539
Atlas_Id 50374
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 130136391 and ends at 130179672 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GLRX3 (10q26.3) / C10orf11 (10q22.2)GLRX3 (10q26.3) / LYRM2 (6q15)HECTD2 (10q23.32) / GLRX3 (10q26.3)
GLRX3 10q26.3 / C10orf11 10q22.2HECTD2 10q23.32 / GLRX3 10q26.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GLRX3   15987
Cards
Entrez_Gene (NCBI)GLRX3    glutaredoxin 3
AliasesGLRX4; GRX3; GRX4; PICOT; 
TXNL2; TXNL3
GeneCards (Weizmann)GLRX3
Ensembl hg19 (Hinxton)ENSG00000108010 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108010 [Gene_View]  ENSG00000108010 [Sequence]  chr10:130136391-130179672 [Contig_View]  GLRX3 [Vega]
ICGC DataPortalENSG00000108010
TCGA cBioPortalGLRX3
AceView (NCBI)GLRX3
Genatlas (Paris)GLRX3
SOURCE (Princeton)GLRX3
Genetics Home Reference (NIH)GLRX3
Genomic and cartography
GoldenPath hg38 (UCSC)GLRX3  -     chr10:130136391-130179672 +  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLRX3  -     10q26.3   [Description]    (hg19-Feb_2009)
GoldenPathGLRX3 - 10q26.3 [CytoView hg19]  GLRX3 - 10q26.3 [CytoView hg38]
ImmunoBaseENSG00000108010
Genome Data Viewer NCBIGLRX3 [Mapview hg19]  
OMIM612754   
Gene and transcription
Genbank (Entrez)AA995117 AF118649 AF118652 AJ010841 AK022131
RefSeq transcript (Entrez)NM_001199868 NM_001321980 NM_006541
Consensus coding sequences : CCDS (NCBI)GLRX3
Gene ExpressionGLRX3 [ NCBI-GEO ]   GLRX3 [ EBI - ARRAY_EXPRESS ]   GLRX3 [ SEEK ]   GLRX3 [ MEM ]
Gene Expression Viewer (FireBrowse)GLRX3 [ Firebrowse - Broad ]
GenevisibleExpression of GLRX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10539
GTEX Portal (Tissue expression)GLRX3
Human Protein AtlasENSG00000108010-GLRX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76003   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76003  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76003
PhosPhoSitePlusO76003
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_2 (PS51354)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Glutaredoxin    GRX_PICOT-like    Monothiol_GRX-rel    Thioredoxin-like_sf    Thioredoxin_domain   
Domain families : Pfam (Sanger)Glutaredoxin (PF00462)    Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00462    pfam00085   
Conserved Domain (NCBI)GLRX3
PDB (RSDB)2DIY    2WZ9    2YAN    3ZYW   
PDB Europe2DIY    2WZ9    2YAN    3ZYW   
PDB (PDBSum)2DIY    2WZ9    2YAN    3ZYW   
PDB (IMB)2DIY    2WZ9    2YAN    3ZYW   
Structural Biology KnowledgeBase2DIY    2WZ9    2YAN    3ZYW   
SCOP (Structural Classification of Proteins)2DIY    2WZ9    2YAN    3ZYW   
CATH (Classification of proteins structures)2DIY    2WZ9    2YAN    3ZYW   
SuperfamilyO76003
AlphaFold pdb e-kbO76003   
Human Protein Atlas [tissue]ENSG00000108010-GLRX3 [tissue]
HPRD10153
Protein Interaction databases
DIP (DOE-UCLA)O76003
IntAct (EBI)O76003
BioGRIDGLRX3
STRING (EMBL)GLRX3
ZODIACGLRX3
Ontologies - Pathways
QuickGOO76003
Ontology : AmiGOregulation of the force of heart contraction  RNA binding  protein kinase C binding  protein binding  nucleus  cytosol  cell cortex  cellular iron ion homeostasis  negative regulation of cardiac muscle hypertrophy  Z disc  dendrite  identical protein binding  [2Fe-2S] cluster assembly  metal ion binding  iron-sulfur cluster binding  protein maturation by iron-sulfur cluster transfer  glutathione oxidoreductase activity  
Ontology : EGO-EBIregulation of the force of heart contraction  RNA binding  protein kinase C binding  protein binding  nucleus  cytosol  cell cortex  cellular iron ion homeostasis  negative regulation of cardiac muscle hypertrophy  Z disc  dendrite  identical protein binding  [2Fe-2S] cluster assembly  metal ion binding  iron-sulfur cluster binding  protein maturation by iron-sulfur cluster transfer  glutathione oxidoreductase activity  
NDEx NetworkGLRX3
Atlas of Cancer Signalling NetworkGLRX3
Wikipedia pathwaysGLRX3
Orthology - Evolution
OrthoDB10539
GeneTree (enSembl)ENSG00000108010
Phylogenetic Trees/Animal Genes : TreeFamGLRX3
Homologs : HomoloGeneGLRX3
Homology/Alignments : Family Browser (UCSC)GLRX3
Gene fusions - Rearrangements
Fusion : MitelmanGLRX3/C10orf11 [10q26.3/10q22.2]  
Fusion : MitelmanHECTD2/GLRX3 [10q23.32/10q26.3]  
Fusion : QuiverGLRX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLRX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLRX3
dbVarGLRX3
ClinVarGLRX3
MonarchGLRX3
1000_GenomesGLRX3 
Exome Variant ServerGLRX3
GNOMAD BrowserENSG00000108010
Varsome BrowserGLRX3
ACMGGLRX3 variants
VarityO76003
Genomic Variants (DGV)GLRX3 [DGVbeta]
DECIPHERGLRX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLRX3 
Mutations
ICGC Data PortalGLRX3 
TCGA Data PortalGLRX3 
Broad Tumor PortalGLRX3
OASIS PortalGLRX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLRX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGLRX3
Mutations and Diseases : HGMDGLRX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGLRX3
DgiDB (Drug Gene Interaction Database)GLRX3
DoCM (Curated mutations)GLRX3
CIViC (Clinical Interpretations of Variants in Cancer)GLRX3
Cancer3DGLRX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612754   
Orphanet
DisGeNETGLRX3
MedgenGLRX3
Genetic Testing Registry GLRX3
NextProtO76003 [Medical]
GENETestsGLRX3
Target ValidationGLRX3
Huge Navigator GLRX3 [HugePedia]
ClinGenGLRX3
Clinical trials, drugs, therapy
MyCancerGenomeGLRX3
Protein Interactions : CTDGLRX3
Pharm GKB GenePA162389829
PharosO76003
Clinical trialGLRX3
Miscellaneous
canSAR (ICR)GLRX3
HarmonizomeGLRX3
DataMed IndexGLRX3
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGLRX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:10:56 CEST 2021

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