GLRX3 (glutaredoxin 3)

2008-09-01  

Identity

HGNC
GLRX3
LOCATION
10q26.3
LOCUSID
10539
ALIAS
GLRX4,GRX3,GRX4,PICOT,TXNL2,TXNL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10539
MIM: 612754
HGNC: 15987
Ensembl: ENSG00000108010

Variants:

dbSNP: 10539
ClinVar: 10539
TCGA: ENSG00000108010
COSMIC: GLRX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108010ENST00000331244O76003
ENSG00000108010ENST00000331244A0A140VJK1
ENSG00000108010ENST00000368644O76003
ENSG00000108010ENST00000368644A0A140VJK1
ENSG00000108010ENST00000481034O76003
ENSG00000108010ENST00000481034A0A140VJK1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
211239482011Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling.49
223097712012Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2.43
236154482013Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.36
202261712010Characterization of the human monothiol glutaredoxin 3 (PICOT) as iron-sulfur protein.34
215751362011A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.24
275194152016A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery.20
263024802015N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin.19
266136762015Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway.19
197970042009Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma.18

Citation

Dessen P

GLRX3 (glutaredoxin 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50374/glrx3