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GLS (glutaminase)

Identity

Alias_symbol (synonym)KIAA0838
GLS1
Other aliasAAD20
GAC
GAM
KGA
HGNC (Hugo) GLS
LocusID (NCBI) 2744
Atlas_Id 45600
Location 2q32.2  [Link to chromosome band 2q32]
Location_base_pair Starts at 191745547 and ends at 191800015 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AHI1 (6q23.3) / GLS (2q32.2)GLS (2q32.2) / PEBP1 (12q24.23)IFT20 (17q11.2) / GLS (2q32.2)
IGBP1 (Xq13.1) / GLS (2q32.2)MYO1B (2q32.3) / GLS (2q32.2)SLC39A8 (4q24) / GLS (2q32.2)
TNRC18 (7p22.1) / GLS (2q32.2)VPS50 (7q21.3) / GLS (2q32.2)MYO1B 2q32.3 / GLS 2q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLS   4331
Cards
Entrez_Gene (NCBI)GLS  2744  glutaminase
AliasesAAD20; GAC; GAM; GLS1; 
KGA
GeneCards (Weizmann)GLS
Ensembl hg19 (Hinxton)ENSG00000115419 [Gene_View]  chr2:191745547-191800015 [Contig_View]  GLS [Vega]
Ensembl hg38 (Hinxton)ENSG00000115419 [Gene_View]  chr2:191745547-191800015 [Contig_View]  GLS [Vega]
ICGC DataPortalENSG00000115419
TCGA cBioPortalGLS
AceView (NCBI)GLS
Genatlas (Paris)GLS
WikiGenes2744
SOURCE (Princeton)GLS
Genetics Home Reference (NIH)GLS
Genomic and cartography
GoldenPath hg19 (UCSC)GLS  -     chr2:191745547-191800015 +  2q32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GLS  -     2q32.2   [Description]    (hg38-Dec_2013)
EnsemblGLS - 2q32.2 [CytoView hg19]  GLS - 2q32.2 [CytoView hg38]
Mapping of homologs : NCBIGLS [Mapview hg19]  GLS [Mapview hg38]
OMIM138280   
Gene and transcription
Genbank (Entrez)AB020645 AF097492 AF097493 AF097494 AF097495
RefSeq transcript (Entrez)NM_001256310 NM_014905
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)GLS
Cluster EST : UnigeneHs.737608 [ NCBI ]
CGAP (NCI)Hs.737608
Alternative Splicing GalleryENSG00000115419
Gene ExpressionGLS [ NCBI-GEO ]   GLS [ EBI - ARRAY_EXPRESS ]   GLS [ SEEK ]   GLS [ MEM ]
Gene Expression Viewer (FireBrowse)GLS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2744
GTEX Portal (Tissue expression)GLS
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94925   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94925  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94925
Splice isoforms : SwissVarO94925
Catalytic activity : Enzyme3.5.1.2 [ Enzyme-Expasy ]   3.5.1.23.5.1.2 [ IntEnz-EBI ]   3.5.1.2 [ BRENDA ]   3.5.1.2 [ KEGG ]   
PhosPhoSitePlusO94925
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Beta-lactam/transpept-like    Glutaminase   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    Glutaminase (PF04960)   
Domain families : Pfam (NCBI)pfam12796    pfam04960   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)GLS
DMDM Disease mutations2744
Blocks (Seattle)GLS
PDB (SRS)3CZD    3UNW    3UO9    3VOY    3VOZ    3VP0    3VP1    3VP2    3VP3    3VP4    4O7D    5D3O   
PDB (PDBSum)3CZD    3UNW    3UO9    3VOY    3VOZ    3VP0    3VP1    3VP2    3VP3    3VP4    4O7D    5D3O   
PDB (IMB)3CZD    3UNW    3UO9    3VOY    3VOZ    3VP0    3VP1    3VP2    3VP3    3VP4    4O7D    5D3O   
PDB (RSDB)3CZD    3UNW    3UO9    3VOY    3VOZ    3VP0    3VP1    3VP2    3VP3    3VP4    4O7D    5D3O   
Structural Biology KnowledgeBase3CZD    3UNW    3UO9    3VOY    3VOZ    3VP0    3VP1    3VP2    3VP3    3VP4    4O7D    5D3O   
SCOP (Structural Classification of Proteins)3CZD    3UNW    3UO9    3VOY    3VOZ    3VP0    3VP1    3VP2    3VP3    3VP4    4O7D    5D3O   
CATH (Classification of proteins structures)3CZD    3UNW    3UO9    3VOY    3VOZ    3VP0    3VP1    3VP2    3VP3    3VP4    4O7D    5D3O   
SuperfamilyO94925
Human Protein AtlasENSG00000115419
Peptide AtlasO94925
HPRD00700
IPIIPI00289159   IPI00215685   IPI00215687   IPI00917826   IPI00917105   IPI01018316   IPI00916210   IPI00916088   IPI00917573   
Protein Interaction databases
DIP (DOE-UCLA)O94925
IntAct (EBI)O94925
FunCoupENSG00000115419
BioGRIDGLS
STRING (EMBL)GLS
ZODIACGLS
Ontologies - Pathways
QuickGOO94925
Ontology : AmiGOsuckling behavior  regulation of respiratory gaseous exchange by neurological system process  glutaminase activity  glutaminase activity  glutaminase activity  protein binding  mitochondrion  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  glutamate biosynthetic process  glutamate biosynthetic process  glutamine catabolic process  glutamine catabolic process  synaptic transmission  cellular amino acid biosynthetic process  glutamate secretion  protein homotetramerization  
Ontology : EGO-EBIsuckling behavior  regulation of respiratory gaseous exchange by neurological system process  glutaminase activity  glutaminase activity  glutaminase activity  protein binding  mitochondrion  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  glutamate biosynthetic process  glutamate biosynthetic process  glutamine catabolic process  glutamine catabolic process  synaptic transmission  cellular amino acid biosynthetic process  glutamate secretion  protein homotetramerization  
Pathways : KEGGAlanine, aspartate and glutamate metabolism    Arginine and proline metabolism    D-Glutamine and D-glutamate metabolism    Glutamatergic synapse    GABAergic synapse    Proximal tubule bicarbonate reclamation    MicroRNAs in cancer   
NDEx NetworkGLS
Atlas of Cancer Signalling NetworkGLS
Wikipedia pathwaysGLS
Orthology - Evolution
OrthoDB2744
GeneTree (enSembl)ENSG00000115419
Phylogenetic Trees/Animal Genes : TreeFamGLS
HOVERGENO94925
HOGENOMO94925
Homologs : HomoloGeneGLS
Homology/Alignments : Family Browser (UCSC)GLS
Gene fusions - Rearrangements
Fusion : MitelmanMYO1B/GLS [2q32.3/2q32.2]  [t(2;2)(q32;q32)]  
Fusion: TCGAMYO1B 2q32.3 GLS 2q32.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLS
dbVarGLS
ClinVarGLS
1000_GenomesGLS 
Exome Variant ServerGLS
ExAC (Exome Aggregation Consortium)GLS (select the gene name)
Genetic variants : HAPMAP2744
Genomic Variants (DGV)GLS [DGVbeta]
DECIPHER (Syndromes)2:191745547-191800015  ENSG00000115419
CONAN: Copy Number AnalysisGLS 
Mutations
ICGC Data PortalGLS 
TCGA Data PortalGLS 
Broad Tumor PortalGLS
OASIS PortalGLS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GLS
DgiDB (Drug Gene Interaction Database)GLS
DoCM (Curated mutations)GLS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLS (select a term)
intoGenGLS
Cancer3DGLS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138280   
Orphanet
MedgenGLS
Genetic Testing Registry GLS
NextProtO94925 [Medical]
TSGene2744
GENETestsGLS
Huge Navigator GLS [HugePedia]
snp3D : Map Gene to Disease2744
BioCentury BCIQGLS
ClinGenGLS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2744
Chemical/Pharm GKB GenePA28734
Clinical trialGLS
Miscellaneous
canSAR (ICR)GLS (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLS
EVEXGLS
GoPubMedGLS
iHOPGLS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:02:32 CEST 2017

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