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GLUD1 (glutamate dehydrogenase 1)

Identity

Alias (NCBI)GDH
GDH1
GLUD
HGNC (Hugo) GLUD1
HGNC Alias symbGDH
HGNC Previous nameGLUD
LocusID (NCBI) 2746
Atlas_Id 53627
Location 10q23.2  [Link to chromosome band 10q23]
Location_base_pair Starts at 87050202 and ends at 87094843 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GLUD1 (10q23.2) / HBG2 (11p15.4)GLUD1 (10q23.2) / UTP6 (17q11.2)GLUD1 (10q23.2) / VPS26A (10q22.1)
UPF2 (10p14) / GLUD1 (10q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GLUD1   4335
Cards
Entrez_Gene (NCBI)GLUD1  2746  glutamate dehydrogenase 1
AliasesGDH; GDH1; GLUD
GeneCards (Weizmann)GLUD1
Ensembl hg19 (Hinxton)ENSG00000148672 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148672 [Gene_View]  ENSG00000148672 [Sequence]  chr10:87050202-87094843 [Contig_View]  GLUD1 [Vega]
ICGC DataPortalENSG00000148672
TCGA cBioPortalGLUD1
AceView (NCBI)GLUD1
Genatlas (Paris)GLUD1
WikiGenes2746
SOURCE (Princeton)GLUD1
Genetics Home Reference (NIH)GLUD1
Genomic and cartography
GoldenPath hg38 (UCSC)GLUD1  -     chr10:87050202-87094843 -  10q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLUD1  -     10q23.2   [Description]    (hg19-Feb_2009)
GoldenPathGLUD1 - 10q23.2 [CytoView hg19]  GLUD1 - 10q23.2 [CytoView hg38]
ImmunoBaseENSG00000148672
genome Data Viewer NCBIGLUD1 [Mapview hg19]  
OMIM138130   606762   
Gene and transcription
Genbank (Entrez)AB209406 AF086070 AK094782 AK122685 AK222818
RefSeq transcript (Entrez)NM_001318900 NM_001318901 NM_001318902 NM_001318904 NM_001318905 NM_001318906 NM_005271
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLUD1
Alternative Splicing GalleryENSG00000148672
Gene ExpressionGLUD1 [ NCBI-GEO ]   GLUD1 [ EBI - ARRAY_EXPRESS ]   GLUD1 [ SEEK ]   GLUD1 [ MEM ]
Gene Expression Viewer (FireBrowse)GLUD1 [ Firebrowse - Broad ]
GenevisibleExpression of GLUD1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2746
GTEX Portal (Tissue expression)GLUD1
Human Protein AtlasENSG00000148672-GLUD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00367   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00367  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00367
Splice isoforms : SwissVarP00367
Catalytic activity : Enzyme1.4.1.3 [ Enzyme-Expasy ]   1.4.1.31.4.1.3 [ IntEnz-EBI ]   1.4.1.3 [ BRENDA ]   1.4.1.3 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP00367
Domaine pattern : Prosite (Expaxy)GLFV_DEHYDROGENASE (PS00074)   
Domains : Interpro (EBI)Glu/Leu/Phe/Val_DH    Glu/Leu/Phe/Val_DH_AS    Glu/Leu/Phe/Val_DH_C    Glu/Leu/Phe/Val_DH_dimer_dom    NAD(P)-bd_dom_sf    NAD_bind_Glu_DH   
Domain families : Pfam (Sanger)ELFV_dehydrog (PF00208)    ELFV_dehydrog_N (PF02812)   
Domain families : Pfam (NCBI)pfam00208    pfam02812   
Domain families : Smart (EMBL)ELFV_dehydrog (SM00839)  
Conserved Domain (NCBI)GLUD1
DMDM Disease mutations2746
Blocks (Seattle)GLUD1
PDB (RSDB)1L1F    1NR1    6DQG   
PDB Europe1L1F    1NR1    6DQG   
PDB (PDBSum)1L1F    1NR1    6DQG   
PDB (IMB)1L1F    1NR1    6DQG   
Structural Biology KnowledgeBase1L1F    1NR1    6DQG   
SCOP (Structural Classification of Proteins)1L1F    1NR1    6DQG   
CATH (Classification of proteins structures)1L1F    1NR1    6DQG   
SuperfamilyP00367
Human Protein Atlas [tissue]ENSG00000148672-GLUD1 [tissue]
Peptide AtlasP00367
HPRD11748
IPIIPI00016801   IPI01015801   IPI01015023   IPI01014382   IPI01010313   IPI00746092   IPI01015433   
Protein Interaction databases
DIP (DOE-UCLA)P00367
IntAct (EBI)P00367
FunCoupENSG00000148672
BioGRIDGLUD1
STRING (EMBL)GLUD1
ZODIACGLUD1
Ontologies - Pathways
QuickGOP00367
Ontology : AmiGOglutamate dehydrogenase (NAD+) activity  glutamate dehydrogenase (NAD+) activity  glutamate dehydrogenase [NAD(P)+] activity  protein binding  ATP binding  GTP binding  cytoplasm  mitochondrion  mitochondrion  mitochondrial matrix  glutamate biosynthetic process  glutamate catabolic process  glutamate catabolic process  glutamine metabolic process  cellular amino acid biosynthetic process  substantia nigra development  positive regulation of insulin secretion  identical protein binding  ADP binding  oxidation-reduction process  NAD+ binding  leucine binding  tricarboxylic acid metabolic process  
Ontology : EGO-EBIglutamate dehydrogenase (NAD+) activity  glutamate dehydrogenase (NAD+) activity  glutamate dehydrogenase [NAD(P)+] activity  protein binding  ATP binding  GTP binding  cytoplasm  mitochondrion  mitochondrion  mitochondrial matrix  glutamate biosynthetic process  glutamate catabolic process  glutamate catabolic process  glutamine metabolic process  cellular amino acid biosynthetic process  substantia nigra development  positive regulation of insulin secretion  identical protein binding  ADP binding  oxidation-reduction process  NAD+ binding  leucine binding  tricarboxylic acid metabolic process  
Pathways : KEGGAlanine, aspartate and glutamate metabolism    Arginine and proline metabolism    D-Glutamine and D-glutamate metabolism    Nitrogen metabolism    Proximal tubule bicarbonate reclamation   
NDEx NetworkGLUD1
Atlas of Cancer Signalling NetworkGLUD1
Wikipedia pathwaysGLUD1
Orthology - Evolution
OrthoDB2746
GeneTree (enSembl)ENSG00000148672
Phylogenetic Trees/Animal Genes : TreeFamGLUD1
HOGENOMP00367
Homologs : HomoloGeneGLUD1
Homology/Alignments : Family Browser (UCSC)GLUD1
Gene fusions - Rearrangements
Fusion : QuiverGLUD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLUD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLUD1
dbVarGLUD1
ClinVarGLUD1
MonarchGLUD1
1000_GenomesGLUD1 
Exome Variant ServerGLUD1
GNOMAD BrowserENSG00000148672
Varsome BrowserGLUD1
Genetic variants : HAPMAP2746
Genomic Variants (DGV)GLUD1 [DGVbeta]
DECIPHERGLUD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLUD1 
Mutations
ICGC Data PortalGLUD1 
TCGA Data PortalGLUD1 
Broad Tumor PortalGLUD1
OASIS PortalGLUD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLUD1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGLUD1
Mutations and Diseases : HGMDGLUD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GLUD1
DgiDB (Drug Gene Interaction Database)GLUD1
DoCM (Curated mutations)GLUD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLUD1 (select a term)
intoGenGLUD1
Cancer3DGLUD1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138130    606762   
Orphanet10403   
DisGeNETGLUD1
MedgenGLUD1
Genetic Testing Registry GLUD1
NextProtP00367 [Medical]
TSGene2746
GENETestsGLUD1
Target ValidationGLUD1
Huge Navigator GLUD1 [HugePedia]
snp3D : Map Gene to Disease2746
BioCentury BCIQGLUD1
ClinGenGLUD1
Clinical trials, drugs, therapy
Protein Interactions : CTD2746
Pharm GKB GenePA28737
Clinical trialGLUD1
Miscellaneous
canSAR (ICR)GLUD1 (select the gene name)
HarmonizomeGLUD1
DataMed IndexGLUD1
Probes
Litterature
PubMed186 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLUD1
EVEXGLUD1
GoPubMedGLUD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:12:51 CEST 2020
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