GLYCTK (glycerate kinase)

2014-11-01  

Identity

HGNC
GLYCTK
LOCATION
3p21.2
LOCUSID
132158
ALIAS
HBEBP2,HBEBP4,HBeAgBP4A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 132158
MIM: 610516
HGNC: 24247
Ensembl: ENSG00000168237

Variants:

dbSNP: 132158
ClinVar: 132158
TCGA: ENSG00000168237
COSMIC: GLYCTK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168237ENST00000305690Q8IVS8
ENSG00000168237ENST00000436784Q8IVS8
ENSG00000168237ENST00000436784A0A024R302
ENSG00000168237ENST00000461183C9J3N5
ENSG00000168237ENST00000471180C9JA32
ENSG00000168237ENST00000473032Q8IVS8
ENSG00000168237ENST00000477382Q8IVS8
ENSG00000168237ENST00000486393A0A0C4DGA0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Glycine, serine and threonine metabolismKEGGko00260
Glycerolipid metabolismKEGGko00561
Glyoxylate and dicarboxylate metabolismKEGGko00630
Pentose phosphate pathwayKEGGhsa00030
Glycine, serine and threonine metabolismKEGGhsa00260
Glycerolipid metabolismKEGGhsa00561
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Fructose metabolismREACTOMER-HSA-5652084
Fructose catabolismREACTOMER-HSA-70350

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
209496202010D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK).5
167538112006Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2.2

Citation

Dessen P

GLYCTK (glycerate kinase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63843/glyctk