GMFG (glia maturation factor gamma)

2017-04-01  

Identity

HGNC
GMFG
LOCATION
19q13.2
LOCUSID
9535
ALIAS
GMF-GAMMA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9535
MIM: 604104
HGNC: 4374
Ensembl: ENSG00000130755

Variants:

dbSNP: 9535
ClinVar: 9535
TCGA: ENSG00000130755
COSMIC: GMFG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130755ENST00000253054M0R0C1
ENSG00000130755ENST00000594700M0QX47
ENSG00000130755ENST00000595207M0R2P2
ENSG00000130755ENST00000595636M0QXC2
ENSG00000130755ENST00000596583M0QXZ6
ENSG00000130755ENST00000597595O60234
ENSG00000130755ENST00000598034M0QYJ8
ENSG00000130755ENST00000600322M0R0C1
ENSG00000130755ENST00000601387M0R1D2
ENSG00000130755ENST00000602185M0QYG8

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
248185512014Glia maturation factor-γ phosphorylation at Tyr-104 regulates actin dynamics and contraction in human airway smooth muscle.18
238978162013Glia maturation factor (GMF) interacts with Arp2/3 complex in a nucleotide state-dependent manner.13
236774652013Glia maturation factor-γ negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages.9
125916112003Structure and promoter activity of the human glia maturation factor-gamma gene: a TATA-less, GC-rich and bidirectional promoter.8
171272122006Glia maturation factor gamma (GMFG): a cytokine-responsive protein during hematopoietic lineage development and its functional genomics analysis.8
225105152012Glia maturation factor gamma regulates the migration and adherence of human T lymphocytes.8
268959642016Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.6
280754542017Expression of glia maturation factor γ is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro.4
308119452019Phosphorylation of GMFγ by c-Abl Coordinates Lamellipodial and Focal Adhesion Dynamics to Regulate Airway Smooth Muscle Cell Migration.3

Citation

Dessen P

GMFG (glia maturation factor gamma)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56763/gmfg