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GMNN (geminin DNA replication inhibitor)

Identity

Alias (NCBI)Gem
MGORS6
HGNC (Hugo) GMNN
HGNC Alias symbGem
LocusID (NCBI) 51053
Atlas_Id 43271
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 24774937 and ends at 24786097 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GMNN (6p22.3)::GMNN (6p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GMNN   17493
Cards
Entrez_Gene (NCBI)GMNN    geminin DNA replication inhibitor
AliasesGem; MGORS6
GeneCards (Weizmann)GMNN
Ensembl hg19 (Hinxton)ENSG00000112312 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112312 [Gene_View]  ENSG00000112312 [Sequence]  chr6:24774937-24786097 [Contig_View]  GMNN [Vega]
ICGC DataPortalENSG00000112312
TCGA cBioPortalGMNN
AceView (NCBI)GMNN
Genatlas (Paris)GMNN
SOURCE (Princeton)GMNN
Genetics Home Reference (NIH)GMNN
Genomic and cartography
GoldenPath hg38 (UCSC)GMNN  -     chr6:24774937-24786097 +  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GMNN  -     6p22.3   [Description]    (hg19-Feb_2009)
GoldenPathGMNN - 6p22.3 [CytoView hg19]  GMNN - 6p22.3 [CytoView hg38]
ImmunoBaseENSG00000112312
Genome Data Viewer NCBIGMNN [Mapview hg19]  
OMIM602842   616835   
Gene and transcription
Genbank (Entrez)AF067855 AK021685 AK222992 AK315743 AL558330
RefSeq transcript (Entrez)NM_001251989 NM_001251990 NM_001251991 NM_015895
Consensus coding sequences : CCDS (NCBI)GMNN
Gene ExpressionGMNN [ NCBI-GEO ]   GMNN [ EBI - ARRAY_EXPRESS ]   GMNN [ SEEK ]   GMNN [ MEM ]
Gene Expression Viewer (FireBrowse)GMNN [ Firebrowse - Broad ]
GenevisibleExpression of GMNN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51053
GTEX Portal (Tissue expression)GMNN
Human Protein AtlasENSG00000112312-GMNN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75496   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75496  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75496
PhosPhoSitePlusO75496
Domains : Interpro (EBI)Geminin    Geminin/Multicilin   
Domain families : Pfam (Sanger)Geminin (PF07412)   
Domain families : Pfam (NCBI)pfam07412   
Conserved Domain (NCBI)GMNN
PDB (RSDB)1T6F    1UII    2LP0    2WVR    4BRY   
PDB Europe1T6F    1UII    2LP0    2WVR    4BRY   
PDB (PDBSum)1T6F    1UII    2LP0    2WVR    4BRY   
PDB (IMB)1T6F    1UII    2LP0    2WVR    4BRY   
Structural Biology KnowledgeBase1T6F    1UII    2LP0    2WVR    4BRY   
SCOP (Structural Classification of Proteins)1T6F    1UII    2LP0    2WVR    4BRY   
CATH (Classification of proteins structures)1T6F    1UII    2LP0    2WVR    4BRY   
SuperfamilyO75496
AlphaFold pdb e-kbO75496   
Human Protein Atlas [tissue]ENSG00000112312-GMNN [tissue]
HPRD06783
Protein Interaction databases
DIP (DOE-UCLA)O75496
IntAct (EBI)O75496
BioGRIDGMNN
STRING (EMBL)GMNN
ZODIACGMNN
Ontologies - Pathways
QuickGOO75496
Ontology : AmiGOchromatin binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  DNA replication initiation  regulation of DNA replication  negative regulation of DNA replication  negative regulation of DNA replication  animal organ morphogenesis  positive regulation of chromatin binding  pre-replicative complex assembly  histone deacetylase binding  negative regulation of cell cycle  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  DNA replication preinitiation complex assembly  DNA-binding transcription factor binding  negative regulation of DNA-dependent DNA replication  
Ontology : EGO-EBIchromatin binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  DNA replication initiation  regulation of DNA replication  negative regulation of DNA replication  negative regulation of DNA replication  animal organ morphogenesis  positive regulation of chromatin binding  pre-replicative complex assembly  histone deacetylase binding  negative regulation of cell cycle  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  DNA replication preinitiation complex assembly  DNA-binding transcription factor binding  negative regulation of DNA-dependent DNA replication  
NDEx NetworkGMNN
Atlas of Cancer Signalling NetworkGMNN
Wikipedia pathwaysGMNN
Orthology - Evolution
OrthoDB51053
GeneTree (enSembl)ENSG00000112312
Phylogenetic Trees/Animal Genes : TreeFamGMNN
Homologs : HomoloGeneGMNN
Homology/Alignments : Family Browser (UCSC)GMNN
Gene fusions - Rearrangements
Fusion : QuiverGMNN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGMNN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GMNN
dbVarGMNN
ClinVarGMNN
MonarchGMNN
1000_GenomesGMNN 
Exome Variant ServerGMNN
GNOMAD BrowserENSG00000112312
Varsome BrowserGMNN
ACMGGMNN variants
VarityO75496
Genomic Variants (DGV)GMNN [DGVbeta]
DECIPHERGMNN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGMNN 
Mutations
ICGC Data PortalGMNN 
TCGA Data PortalGMNN 
Broad Tumor PortalGMNN
OASIS PortalGMNN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGMNN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGMNN
Mutations and Diseases : HGMDGMNN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGMNN
DgiDB (Drug Gene Interaction Database)GMNN
DoCM (Curated mutations)GMNN
CIViC (Clinical Interpretations of Variants in Cancer)GMNN
Cancer3DGMNN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602842    616835   
Orphanet2357   
DisGeNETGMNN
MedgenGMNN
Genetic Testing Registry GMNN
NextProtO75496 [Medical]
GENETestsGMNN
Target ValidationGMNN
Huge Navigator GMNN [HugePedia]
ClinGenGMNN
Clinical trials, drugs, therapy
MyCancerGenomeGMNN
Protein Interactions : CTDGMNN
Pharm GKB GenePA38455
PharosO75496
Clinical trialGMNN
Miscellaneous
canSAR (ICR)GMNN
HarmonizomeGMNN
ARCHS4GMNN
DataMed IndexGMNN
Probes
Litterature
PubMed122 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGMNN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:12:36 CET 2022

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