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GNA13 (G protein subunit alpha 13)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Alias_symbol (synonym)G13
MGC46138
Other alias
HGNC (Hugo) GNA13
LocusID (NCBI) 10672
Atlas_Id 43273
Location 17q24.1  [Link to chromosome band 17q24]
Location_base_pair Starts at 65009289 and ends at 65055774 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CYB561 (17q23.3) / GNA13 (17q24.1)GNA13 (17q24.1) / BMI1 (10p12.2)GNA13 (17q24.1) / CCDC171 (9p22.3)
GNA13 (17q24.1) / CEP112 (17q24.1)GNA13 (17q24.1) / GNA13 (17q24.1)GNA13 (17q24.1) / NR3C1 (5q31.3)
GNA13 (17q24.1) / PHF21A (11p11.2)LRCH3 (3q29) / GNA13 (17q24.1)MIR548AE2 (16q12.1) / GNA13 (17q24.1)
CYB561 17q23.3 / GNA13 17q24.1GNA13 17q24.1 / BMI1 10p12.2GNA13 17q24.1 C9orf93
GNA13 17q24.1 / CEP112 17q24.1GNA13 17q24.1 / NR3C1 5q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNA13   4381
Cards
Entrez_Gene (NCBI)GNA13  10672  G protein subunit alpha 13
AliasesG13
GeneCards (Weizmann)GNA13
Ensembl hg19 (Hinxton)ENSG00000120063 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120063 [Gene_View]  chr17:65009289-65055774 [Contig_View]  GNA13 [Vega]
ICGC DataPortalENSG00000120063
TCGA cBioPortalGNA13
AceView (NCBI)GNA13
Genatlas (Paris)GNA13
WikiGenes10672
SOURCE (Princeton)GNA13
Genetics Home Reference (NIH)GNA13
Genomic and cartography
GoldenPath hg38 (UCSC)GNA13  -     chr17:65009289-65055774 -  17q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNA13  -     17q24.1   [Description]    (hg19-Feb_2009)
EnsemblGNA13 - 17q24.1 [CytoView hg19]  GNA13 - 17q24.1 [CytoView hg38]
Mapping of homologs : NCBIGNA13 [Mapview hg19]  GNA13 [Mapview hg38]
OMIM604406   
Gene and transcription
Genbank (Entrez)AB075500 AF493902 AK002117 AK026902 AK301699
RefSeq transcript (Entrez)NM_001282425 NM_006572
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNA13
Cluster EST : UnigeneHs.515018 [ NCBI ]
CGAP (NCI)Hs.515018
Alternative Splicing GalleryENSG00000120063
Gene ExpressionGNA13 [ NCBI-GEO ]   GNA13 [ EBI - ARRAY_EXPRESS ]   GNA13 [ SEEK ]   GNA13 [ MEM ]
Gene Expression Viewer (FireBrowse)GNA13 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10672
GTEX Portal (Tissue expression)GNA13
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14344   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14344  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14344
Splice isoforms : SwissVarQ14344
PhosPhoSitePlusQ14344
Domains : Interpro (EBI)Gprotein_alpha_12/13    Gprotein_alpha_su    GproteinA_insert    P-loop_NTPase   
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
Conserved Domain (NCBI)GNA13
DMDM Disease mutations10672
Blocks (Seattle)GNA13
SuperfamilyQ14344
Human Protein AtlasENSG00000120063
Peptide AtlasQ14344
HPRD05100
IPIIPI00290928   IPI01012045   IPI00922608   
Protein Interaction databases
DIP (DOE-UCLA)Q14344
IntAct (EBI)Q14344
FunCoupENSG00000120063
BioGRIDGNA13
STRING (EMBL)GNA13
ZODIACGNA13
Ontologies - Pathways
QuickGOQ14344
Ontology : AmiGObranching involved in blood vessel morphogenesis  in utero embryonic development  GTPase activity  GTPase activity  signal transducer activity  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  GTP binding  nucleus  cytosol  heterotrimeric G-protein complex  plasma membrane  focal adhesion  movement of cell or subcellular component  signal transduction  adenylate cyclase-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Rho protein signal transduction  regulation of cell shape  membrane  cell differentiation  platelet activation  regulation of cell migration  brush border membrane  activation of phospholipase D activity  G-protein beta/gamma-subunit complex binding  type 1 angiotensin receptor binding  D5 dopamine receptor binding  melanosome  positive regulation of apoptotic process  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  extracellular exosome  
Ontology : EGO-EBIbranching involved in blood vessel morphogenesis  in utero embryonic development  GTPase activity  GTPase activity  signal transducer activity  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  GTP binding  nucleus  cytosol  heterotrimeric G-protein complex  plasma membrane  focal adhesion  movement of cell or subcellular component  signal transduction  adenylate cyclase-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Rho protein signal transduction  regulation of cell shape  membrane  cell differentiation  platelet activation  regulation of cell migration  brush border membrane  activation of phospholipase D activity  G-protein beta/gamma-subunit complex binding  type 1 angiotensin receptor binding  D5 dopamine receptor binding  melanosome  positive regulation of apoptotic process  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  extracellular exosome  
Pathways : BIOCARTAPKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Genes]    Thrombin signaling and protease-activated receptors [Genes]   
Pathways : KEGGVascular smooth muscle contraction    Long-term depression    Regulation of actin cytoskeleton   
NDEx NetworkGNA13
Atlas of Cancer Signalling NetworkGNA13
Wikipedia pathwaysGNA13
Orthology - Evolution
OrthoDB10672
GeneTree (enSembl)ENSG00000120063
Phylogenetic Trees/Animal Genes : TreeFamGNA13
HOVERGENQ14344
HOGENOMQ14344
Homologs : HomoloGeneGNA13
Homology/Alignments : Family Browser (UCSC)GNA13
Gene fusions - Rearrangements
Fusion : MitelmanCYB561/GNA13 [17q23.3/17q24.1]  [t(17;17)(q23;q24)]  
Fusion : MitelmanGNA13/BMI1 [17q24.1/10p12.2]  [t(10;17)(p12;q24)]  
Fusion : MitelmanGNA13/CCDC171 [17q24.1/9p22.3]  [t(9;17)(p22;q24)]  
Fusion : MitelmanGNA13/CEP112 [17q24.1/17q24.1]  [t(17;17)(q24;q24)]  
Fusion : MitelmanGNA13/NR3C1 [17q24.1/5q31.3]  [t(5;17)(q31;q24)]  
Fusion: TCGACYB561 17q23.3 GNA13 17q24.1 BRCA
Fusion: TCGAGNA13 17q24.1 BMI1 10p12.2 HNSC
Fusion: TCGAGNA13 17q24.1 C9orf93 LUSC
Fusion: TCGAGNA13 17q24.1 CEP112 17q24.1 LUSC
Fusion: TCGAGNA13 17q24.1 NR3C1 5q31.3 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNA13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNA13
dbVarGNA13
ClinVarGNA13
1000_GenomesGNA13 
Exome Variant ServerGNA13
ExAC (Exome Aggregation Consortium)GNA13 (select the gene name)
Genetic variants : HAPMAP10672
Genomic Variants (DGV)GNA13 [DGVbeta]
DECIPHERGNA13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNA13 
Mutations
ICGC Data PortalGNA13 
TCGA Data PortalGNA13 
Broad Tumor PortalGNA13
OASIS PortalGNA13 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNA13  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNA13
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNA13
DgiDB (Drug Gene Interaction Database)GNA13
DoCM (Curated mutations)GNA13 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNA13 (select a term)
intoGenGNA13
Cancer3DGNA13(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604406   
Orphanet
MedgenGNA13
Genetic Testing Registry GNA13
NextProtQ14344 [Medical]
TSGene10672
GENETestsGNA13
Huge Navigator GNA13 [HugePedia]
snp3D : Map Gene to Disease10672
BioCentury BCIQGNA13
ClinGenGNA13
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10672
Chemical/Pharm GKB GenePA28766
Clinical trialGNA13
Miscellaneous
canSAR (ICR)GNA13 (select the gene name)
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNA13
EVEXGNA13
GoPubMedGNA13
iHOPGNA13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:17:28 CEST 2017

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