GNA13 (G protein subunit alpha 13)

2006-10-01  

Identity

HGNC
LOCATION
17q24.1
LOCUSID
ALIAS
G13
FUSION GENES

Other Information

Locus ID:

NCBI: 10672
MIM: 604406
HGNC: 4381
Ensembl: ENSG00000120063

Variants:

dbSNP: 10672
ClinVar: 10672
TCGA: ENSG00000120063
COSMIC: GNA13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120063ENST00000439174Q14344
ENSG00000120063ENST00000439174A0A024R8M0
ENSG00000120063ENST00000541118Q14344

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Long-term depressionKEGGko04730
Regulation of actin cytoskeletonKEGGko04810
Long-term depressionKEGGhsa04730
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Platelet activationKEGGhsa04611
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
Thromboxane signalling through TP receptorREACTOMER-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285527oxaliplatinChemicalMultilinkAnnotationassociated24444404
PA27946F2RGenePathwayassociated20938371
PA27949F2RL3GenePathwayassociated20938371
PA32868P2RY1GenePathwayassociated20938371
PA33384PLCB1GenePathwayassociated20938371
PA33393PLCG2GenePathwayassociated20938371
PA348TBXA2RGenePathwayassociated20938371

References

Pubmed IDYearTitleCitations
236996012013Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.138
200752542010G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling.93
252743072014Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.89
192262832009Regulation of RhoGEF proteins by G12/13-coupled receptors.80
166010722006Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway.64
170565912006The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
167879202006A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.61
219341062011A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells.57
122975122002Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets.39

Citation

Dessen P

GNA13 (G protein subunit alpha 13)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43273/gna13