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GNA13 (G protein subunit alpha 13)

Identity

Alias (NCBI)G13
HGNC (Hugo) GNA13
HGNC Alias symbG13
MGC46138
HGNC Previous nameguanine nucleotide binding protein (G protein), alpha 13
LocusID (NCBI) 10672
Atlas_Id 43273
Location 17q24.1  [Link to chromosome band 17q24]
Location_base_pair Starts at 65009289 and ends at 65056740 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYB561 (17q23.3) / GNA13 (17q24.1)GNA13 (17q24.1) / BMI1 (10p12.2)GNA13 (17q24.1) / CCDC171 (9p22.3)
GNA13 (17q24.1) / CEP112 (17q24.1)GNA13 (17q24.1) / GNA13 (17q24.1)GNA13 (17q24.1) / NR3C1 (5q31.3)
GNA13 (17q24.1) / PHF21A (11p11.2)LRCH3 (3q29) / GNA13 (17q24.1)MIR548AE2 (16q12.1) / GNA13 (17q24.1)
CYB561 17q23.3 / GNA13 17q24.1GNA13 17q24.1 / BMI1 10p12.2GNA13 17q24.1 C9orf93
GNA13 17q24.1 / CEP112 17q24.1GNA13 17q24.1 / NR3C1 5q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Germinal center B-cell-like diffuse Large B-cell Lymphoma (GCB) DLBCL


External links

 

Nomenclature
HGNC (Hugo)GNA13   4381
Cards
Entrez_Gene (NCBI)GNA13    G protein subunit alpha 13
AliasesG13
GeneCards (Weizmann)GNA13
Ensembl hg19 (Hinxton)ENSG00000120063 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120063 [Gene_View]  ENSG00000120063 [Sequence]  chr17:65009289-65056740 [Contig_View]  GNA13 [Vega]
ICGC DataPortalENSG00000120063
TCGA cBioPortalGNA13
AceView (NCBI)GNA13
Genatlas (Paris)GNA13
SOURCE (Princeton)GNA13
Genetics Home Reference (NIH)GNA13
Genomic and cartography
GoldenPath hg38 (UCSC)GNA13  -     chr17:65009289-65056740 -  17q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNA13  -     17q24.1   [Description]    (hg19-Feb_2009)
GoldenPathGNA13 - 17q24.1 [CytoView hg19]  GNA13 - 17q24.1 [CytoView hg38]
ImmunoBaseENSG00000120063
Genome Data Viewer NCBIGNA13 [Mapview hg19]  
OMIM604406   
Gene and transcription
Genbank (Entrez)AB075500 AF493902 AK002117 AK026902 AK301699
RefSeq transcript (Entrez)NM_001282425 NM_006572
Consensus coding sequences : CCDS (NCBI)GNA13
Gene ExpressionGNA13 [ NCBI-GEO ]   GNA13 [ EBI - ARRAY_EXPRESS ]   GNA13 [ SEEK ]   GNA13 [ MEM ]
Gene Expression Viewer (FireBrowse)GNA13 [ Firebrowse - Broad ]
GenevisibleExpression of GNA13 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10672
GTEX Portal (Tissue expression)GNA13
Human Protein AtlasENSG00000120063-GNA13 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14344   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14344  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14344
PhosPhoSitePlusQ14344
Domaine pattern : Prosite (Expaxy)G_ALPHA (PS51882)   
Domains : Interpro (EBI)Gprotein_alpha_12/13    Gprotein_alpha_su    GproteinA_insert    P-loop_NTPase   
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
Conserved Domain (NCBI)GNA13
SuperfamilyQ14344
AlphaFold pdb e-kbQ14344   
Human Protein Atlas [tissue]ENSG00000120063-GNA13 [tissue]
HPRD05100
Protein Interaction databases
DIP (DOE-UCLA)Q14344
IntAct (EBI)Q14344
BioGRIDGNA13
STRING (EMBL)GNA13
ZODIACGNA13
Ontologies - Pathways
QuickGOQ14344
Ontology : AmiGOG protein-coupled receptor binding  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  cytosol  heterotrimeric G-protein complex  plasma membrane  focal adhesion  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Rho protein signal transduction  membrane  platelet activation  brush border membrane  activation of phospholipase D activity  G-protein beta/gamma-subunit complex binding  D5 dopamine receptor binding  melanosome  positive regulation of apoptotic process  metal ion binding  regulation of small GTPase mediated signal transduction  extracellular exosome  negative regulation of vascular associated smooth muscle cell proliferation  negative regulation of vascular associated smooth muscle cell migration  
Ontology : EGO-EBIG protein-coupled receptor binding  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  cytosol  heterotrimeric G-protein complex  plasma membrane  focal adhesion  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Rho protein signal transduction  membrane  platelet activation  brush border membrane  activation of phospholipase D activity  G-protein beta/gamma-subunit complex binding  D5 dopamine receptor binding  melanosome  positive regulation of apoptotic process  metal ion binding  regulation of small GTPase mediated signal transduction  extracellular exosome  negative regulation of vascular associated smooth muscle cell proliferation  negative regulation of vascular associated smooth muscle cell migration  
Pathways : BIOCARTAPKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Genes]    Thrombin signaling and protease-activated receptors [Genes]   
Pathways : KEGGVascular smooth muscle contraction    Long-term depression    Regulation of actin cytoskeleton   
NDEx NetworkGNA13
Atlas of Cancer Signalling NetworkGNA13
Wikipedia pathwaysGNA13
Orthology - Evolution
OrthoDB10672
GeneTree (enSembl)ENSG00000120063
Phylogenetic Trees/Animal Genes : TreeFamGNA13
Homologs : HomoloGeneGNA13
Homology/Alignments : Family Browser (UCSC)GNA13
Gene fusions - Rearrangements
Fusion : MitelmanCYB561/GNA13 [17q23.3/17q24.1]  
Fusion : MitelmanGNA13/BMI1 [17q24.1/10p12.2]  
Fusion : MitelmanGNA13/CCDC171 [17q24.1/9p22.3]  
Fusion : MitelmanGNA13/CEP112 [17q24.1/17q24.1]  
Fusion : MitelmanGNA13/NR3C1 [17q24.1/5q31.3]  
Fusion : QuiverGNA13
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNA13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNA13
dbVarGNA13
ClinVarGNA13
MonarchGNA13
1000_GenomesGNA13 
Exome Variant ServerGNA13
GNOMAD BrowserENSG00000120063
Varsome BrowserGNA13
ACMGGNA13 variants
VarityQ14344
Genomic Variants (DGV)GNA13 [DGVbeta]
DECIPHERGNA13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNA13 
Mutations
ICGC Data PortalGNA13 
TCGA Data PortalGNA13 
Broad Tumor PortalGNA13
OASIS PortalGNA13 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNA13  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGNA13
Mutations and Diseases : HGMDGNA13
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGNA13
DgiDB (Drug Gene Interaction Database)GNA13
DoCM (Curated mutations)GNA13
CIViC (Clinical Interpretations of Variants in Cancer)GNA13
Cancer3DGNA13
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604406   
Orphanet
DisGeNETGNA13
MedgenGNA13
Genetic Testing Registry GNA13
NextProtQ14344 [Medical]
GENETestsGNA13
Target ValidationGNA13
Huge Navigator GNA13 [HugePedia]
ClinGenGNA13
Clinical trials, drugs, therapy
MyCancerGenomeGNA13
Protein Interactions : CTDGNA13
Pharm GKB GenePA28766
Pharm GKB PathwaysPA154444041   
PharosQ14344
Clinical trialGNA13
Miscellaneous
canSAR (ICR)GNA13
HarmonizomeGNA13
DataMed IndexGNA13
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGNA13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:10:59 CEST 2021

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