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GNAI1 (G protein subunit alpha i1)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Other aliasGi
HGNC (Hugo) GNAI1
LocusID (NCBI) 2770
Atlas_Id 43276
Location 7q21.11  [Link to chromosome band 7q21]
Location_base_pair Starts at 79765071 and ends at 79848725 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GNAI1 (7q21.11) / BRAF (7q34)GNAI1 (7q21.11) / MALAT1 (11q13.1)GNAI1 7q21.11 / BRAF 7q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNAI1   4384
Cards
Entrez_Gene (NCBI)GNAI1  2770  G protein subunit alpha i1
AliasesGi
GeneCards (Weizmann)GNAI1
Ensembl hg19 (Hinxton)ENSG00000127955 [Gene_View]  chr7:79765071-79848725 [Contig_View]  GNAI1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000127955 [Gene_View]  chr7:79765071-79848725 [Contig_View]  GNAI1 [Vega]
ICGC DataPortalENSG00000127955
TCGA cBioPortalGNAI1
AceView (NCBI)GNAI1
Genatlas (Paris)GNAI1
WikiGenes2770
SOURCE (Princeton)GNAI1
Genetics Home Reference (NIH)GNAI1
Genomic and cartography
GoldenPath hg19 (UCSC)GNAI1  -     chr7:79765071-79848725 +  7q21.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GNAI1  -     7q21.11   [Description]    (hg38-Dec_2013)
EnsemblGNAI1 - 7q21.11 [CytoView hg19]  GNAI1 - 7q21.11 [CytoView hg38]
Mapping of homologs : NCBIGNAI1 [Mapview hg19]  GNAI1 [Mapview hg38]
OMIM139310   
Gene and transcription
Genbank (Entrez)AF055013 AF493905 AI878901 AK292953 AK304442
RefSeq transcript (Entrez)NM_001256414 NM_002069
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)GNAI1
Cluster EST : UnigeneHs.134587 [ NCBI ]
CGAP (NCI)Hs.134587
Alternative Splicing GalleryENSG00000127955
Gene ExpressionGNAI1 [ NCBI-GEO ]   GNAI1 [ EBI - ARRAY_EXPRESS ]   GNAI1 [ SEEK ]   GNAI1 [ MEM ]
Gene Expression Viewer (FireBrowse)GNAI1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2770
GTEX Portal (Tissue expression)GNAI1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63096   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63096  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63096
Splice isoforms : SwissVarP63096
PhosPhoSitePlusP63096
Domains : Interpro (EBI)Gprotein_alpha_I    Gprotein_alpha_su    GproteinA_insert    P-loop_NTPase   
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
Conserved Domain (NCBI)GNAI1
DMDM Disease mutations2770
Blocks (Seattle)GNAI1
PDB (SRS)1KJY    1Y3A    2G83    2GTP    2IK8    2OM2    2XNS    3ONW    3QE0    3QI2    3UMR    3UMS    4G5Q   
PDB (PDBSum)1KJY    1Y3A    2G83    2GTP    2IK8    2OM2    2XNS    3ONW    3QE0    3QI2    3UMR    3UMS    4G5Q   
PDB (IMB)1KJY    1Y3A    2G83    2GTP    2IK8    2OM2    2XNS    3ONW    3QE0    3QI2    3UMR    3UMS    4G5Q   
PDB (RSDB)1KJY    1Y3A    2G83    2GTP    2IK8    2OM2    2XNS    3ONW    3QE0    3QI2    3UMR    3UMS    4G5Q   
Structural Biology KnowledgeBase1KJY    1Y3A    2G83    2GTP    2IK8    2OM2    2XNS    3ONW    3QE0    3QI2    3UMR    3UMS    4G5Q   
SCOP (Structural Classification of Proteins)1KJY    1Y3A    2G83    2GTP    2IK8    2OM2    2XNS    3ONW    3QE0    3QI2    3UMR    3UMS    4G5Q   
CATH (Classification of proteins structures)1KJY    1Y3A    2G83    2GTP    2IK8    2OM2    2XNS    3ONW    3QE0    3QI2    3UMR    3UMS    4G5Q   
SuperfamilyP63096
Human Protein AtlasENSG00000127955
Peptide AtlasP63096
HPRD00756
IPIIPI00337415   IPI00925531   IPI00925310   IPI00925068   IPI00924868   
Protein Interaction databases
DIP (DOE-UCLA)P63096
IntAct (EBI)P63096
FunCoupENSG00000127955
BioGRIDGNAI1
STRING (EMBL)GNAI1
ZODIACGNAI1
Ontologies - Pathways
QuickGOP63096
Ontology : AmiGOmagnesium ion binding  G-protein coupled receptor binding  GTPase activity  GTPase activity  signal transducer activity  protein binding  GTP binding  GTP binding  nucleus  cytoplasm  lysosomal membrane  centrosome  heterotrimeric G-protein complex  plasma membrane  plasma membrane  protein folding  cell cycle  G-protein coupled receptor signaling pathway  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  metabolic process  GDP binding  midbody  G-protein beta/gamma-subunit complex binding  G-protein coupled serotonin receptor binding  GTPase activating protein binding  response to peptide hormone  regulation of cAMP-mediated signaling  membrane raft  negative regulation of synaptic transmission  cell division  extracellular exosome  cellular response to forskolin  
Ontology : EGO-EBImagnesium ion binding  G-protein coupled receptor binding  GTPase activity  GTPase activity  signal transducer activity  protein binding  GTP binding  GTP binding  nucleus  cytoplasm  lysosomal membrane  centrosome  heterotrimeric G-protein complex  plasma membrane  plasma membrane  protein folding  cell cycle  G-protein coupled receptor signaling pathway  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  metabolic process  GDP binding  midbody  G-protein beta/gamma-subunit complex binding  G-protein coupled serotonin receptor binding  GTPase activating protein binding  response to peptide hormone  regulation of cAMP-mediated signaling  membrane raft  negative regulation of synaptic transmission  cell division  extracellular exosome  cellular response to forskolin  
Pathways : KEGGRap1 signaling pathway    Chemokine signaling pathway    Adrenergic signaling in cardiomyocytes    Axon guidance    Tight junction    Gap junction    Leukocyte transendothelial migration    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Long-term depression    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Gastric acid secretion    Parkinson's disease    Cocaine addiction    Morphine addiction    Alcoholism    Pertussis    Chagas disease (American trypanosomiasis)    Toxoplasmosis   
NDEx NetworkGNAI1
Atlas of Cancer Signalling NetworkGNAI1
Wikipedia pathwaysGNAI1
Orthology - Evolution
OrthoDB2770
GeneTree (enSembl)ENSG00000127955
Phylogenetic Trees/Animal Genes : TreeFamGNAI1
HOVERGENP63096
HOGENOMP63096
Homologs : HomoloGeneGNAI1
Homology/Alignments : Family Browser (UCSC)GNAI1
Gene fusions - Rearrangements
Fusion : MitelmanGNAI1/BRAF [7q21.11/7q34]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNAI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNAI1
dbVarGNAI1
ClinVarGNAI1
1000_GenomesGNAI1 
Exome Variant ServerGNAI1
ExAC (Exome Aggregation Consortium)GNAI1 (select the gene name)
Genetic variants : HAPMAP2770
Genomic Variants (DGV)GNAI1 [DGVbeta]
DECIPHER (Syndromes)7:79765071-79848725  ENSG00000127955
CONAN: Copy Number AnalysisGNAI1 
Mutations
ICGC Data PortalGNAI1 
TCGA Data PortalGNAI1 
Broad Tumor PortalGNAI1
OASIS PortalGNAI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNAI1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNAI1
intOGen PortalGNAI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNAI1
DgiDB (Drug Gene Interaction Database)GNAI1
DoCM (Curated mutations)GNAI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNAI1 (select a term)
intoGenGNAI1
Cancer3DGNAI1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139310   
Orphanet
MedgenGNAI1
Genetic Testing Registry GNAI1
NextProtP63096 [Medical]
TSGene2770
GENETestsGNAI1
Huge Navigator GNAI1 [HugePedia]
snp3D : Map Gene to Disease2770
BioCentury BCIQGNAI1
ClinGenGNAI1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2770
Chemical/Pharm GKB GenePA172
Clinical trialGNAI1
Miscellaneous
canSAR (ICR)GNAI1 (select the gene name)
Probes
Litterature
PubMed160 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNAI1
EVEXGNAI1
GoPubMedGNAI1
iHOPGNAI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:02:36 CEST 2017

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