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GNAI2 (G protein subunit alpha i2)

Identity

Alias (NCBI)GIP
GNAI2B
H_LUCA15.1
H_LUCA16.1
HGNC (Hugo) GNAI2
HGNC Alias symbGIP
HGNC Alias nameGTP-binding regulatory protein Gi alpha-2 chain
HGNC Previous nameGNAI2B
HGNC Previous nameguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
LocusID (NCBI) 2771
Atlas_Id 40726
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 50236204 and ends at 50259362 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GNAI2 (3p21.31) / GNAI2 (3p21.31)GNAI2 (3p21.31) / H19 (11p15.5)GNAI2 (3p21.31) / MBD5 (2q23.1)
GNAI2 (3p21.31) / NT5DC2 (3p21.1)GNAI2 (3p21.31) / PRKAG1 (12q13.12)GNAI2 (3p21.31) / PSAP (10q22.1)
HSP90AA1 (14q32.31) / GNAI2 (3p21.31)LOC100128993 (8p21.3) / GNAI2 (3p21.31)MBD5 (2q23.1) / GNAI2 (3p21.31)
NPIPB7 (16q23.1) / GNAI2 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)GNAI2   4385
Cards
Entrez_Gene (NCBI)GNAI2  2771  G protein subunit alpha i2
AliasesGIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
GeneCards (Weizmann)GNAI2
Ensembl hg19 (Hinxton)ENSG00000114353 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114353 [Gene_View]  ENSG00000114353 [Sequence]  chr3:50236204-50259362 [Contig_View]  GNAI2 [Vega]
ICGC DataPortalENSG00000114353
TCGA cBioPortalGNAI2
AceView (NCBI)GNAI2
Genatlas (Paris)GNAI2
WikiGenes2771
SOURCE (Princeton)GNAI2
Genetics Home Reference (NIH)GNAI2
Genomic and cartography
GoldenPath hg38 (UCSC)GNAI2  -     chr3:50236204-50259362 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNAI2  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathGNAI2 - 3p21.31 [CytoView hg19]  GNAI2 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000114353
genome Data Viewer NCBIGNAI2 [Mapview hg19]  
OMIM139360   192605   
Gene and transcription
Genbank (Entrez)AF493906 AK055574 AK096299 AK096595 AK126708
RefSeq transcript (Entrez)NM_001166425 NM_001282617 NM_001282618 NM_001282619 NM_001282620 NM_002070
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNAI2
Alternative Splicing GalleryENSG00000114353
Gene ExpressionGNAI2 [ NCBI-GEO ]   GNAI2 [ EBI - ARRAY_EXPRESS ]   GNAI2 [ SEEK ]   GNAI2 [ MEM ]
Gene Expression Viewer (FireBrowse)GNAI2 [ Firebrowse - Broad ]
GenevisibleExpression of GNAI2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2771
GTEX Portal (Tissue expression)GNAI2
Human Protein AtlasENSG00000114353-GNAI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04899   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04899  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04899
Splice isoforms : SwissVarP04899
PhosPhoSitePlusP04899
Domaine pattern : Prosite (Expaxy)G_ALPHA (PS51882)   
Domains : Interpro (EBI)Gprotein_alpha_I    Gprotein_alpha_su    GproteinA_insert    P-loop_NTPase   
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
Conserved Domain (NCBI)GNAI2
DMDM Disease mutations2771
Blocks (Seattle)GNAI2
PDB (RSDB)6D9H   
PDB Europe6D9H   
PDB (PDBSum)6D9H   
PDB (IMB)6D9H   
Structural Biology KnowledgeBase6D9H   
SCOP (Structural Classification of Proteins)6D9H   
CATH (Classification of proteins structures)6D9H   
SuperfamilyP04899
Human Protein Atlas [tissue]ENSG00000114353-GNAI2 [tissue]
Peptide AtlasP04899
HPRD00764
IPIIPI00748145   IPI00217906   IPI00926935   IPI01015661   IPI00925504   IPI00924892   IPI00924659   IPI00924427   
Protein Interaction databases
DIP (DOE-UCLA)P04899
IntAct (EBI)P04899
FunCoupENSG00000114353
BioGRIDGNAI2
STRING (EMBL)GNAI2
ZODIACGNAI2
Ontologies - Pathways
QuickGOP04899
Ontology : AmiGOG protein-coupled receptor binding  adenosine receptor signaling pathway  GTPase activity  protein binding  GTP binding  nucleoplasm  cytoplasm  centrosome  cytosol  heterotrimeric G-protein complex  plasma membrane  plasma membrane  protein folding  cell cycle  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  G protein-coupled acetylcholine receptor signaling pathway  gamma-aminobutyric acid signaling pathway  response to nutrient  cell proliferation  positive regulation of cell proliferation  membrane  positive regulation of cell migration  dendrite  midbody  G-protein beta/gamma-subunit complex binding  positive regulation of superoxide anion generation  positive regulation of NAD(P)H oxidase activity  positive regulation of urine volume  positive regulation of renal sodium excretion  cell body  membrane raft  synapse  negative regulation of calcium ion-dependent exocytosis  positive regulation of insulin receptor signaling pathway  metal ion binding  negative regulation of synaptic transmission  cell division  regulation of calcium ion transport  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  extracellular vesicle  negative regulation of protein tyrosine phosphatase activity  positive regulation of vascular smooth muscle cell proliferation  positive regulation of neural precursor cell proliferation  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBIG protein-coupled receptor binding  adenosine receptor signaling pathway  GTPase activity  protein binding  GTP binding  nucleoplasm  cytoplasm  centrosome  cytosol  heterotrimeric G-protein complex  plasma membrane  plasma membrane  protein folding  cell cycle  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  G protein-coupled acetylcholine receptor signaling pathway  gamma-aminobutyric acid signaling pathway  response to nutrient  cell proliferation  positive regulation of cell proliferation  membrane  positive regulation of cell migration  dendrite  midbody  G-protein beta/gamma-subunit complex binding  positive regulation of superoxide anion generation  positive regulation of NAD(P)H oxidase activity  positive regulation of urine volume  positive regulation of renal sodium excretion  cell body  membrane raft  synapse  negative regulation of calcium ion-dependent exocytosis  positive regulation of insulin receptor signaling pathway  metal ion binding  negative regulation of synaptic transmission  cell division  regulation of calcium ion transport  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  extracellular vesicle  negative regulation of protein tyrosine phosphatase activity  positive regulation of vascular smooth muscle cell proliferation  positive regulation of neural precursor cell proliferation  negative regulation of apoptotic signaling pathway  
Pathways : KEGGRap1 signaling pathway    Chemokine signaling pathway    Adrenergic signaling in cardiomyocytes    Axon guidance    Tight junction    Gap junction    Leukocyte transendothelial migration    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Long-term depression    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Gastric acid secretion    Parkinson's disease    Cocaine addiction    Morphine addiction    Alcoholism    Pertussis    Chagas disease (American trypanosomiasis)    Toxoplasmosis   
NDEx NetworkGNAI2
Atlas of Cancer Signalling NetworkGNAI2
Wikipedia pathwaysGNAI2
Orthology - Evolution
OrthoDB2771
GeneTree (enSembl)ENSG00000114353
Phylogenetic Trees/Animal Genes : TreeFamGNAI2
HOGENOMP04899
Homologs : HomoloGeneGNAI2
Homology/Alignments : Family Browser (UCSC)GNAI2
Gene fusions - Rearrangements
Fusion : QuiverGNAI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNAI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNAI2
dbVarGNAI2
ClinVarGNAI2
MonarchGNAI2
1000_GenomesGNAI2 
Exome Variant ServerGNAI2
GNOMAD BrowserENSG00000114353
Varsome BrowserGNAI2
Genetic variants : HAPMAP2771
Genomic Variants (DGV)GNAI2 [DGVbeta]
DECIPHERGNAI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNAI2 
Mutations
ICGC Data PortalGNAI2 
TCGA Data PortalGNAI2 
Broad Tumor PortalGNAI2
OASIS PortalGNAI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNAI2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGNAI2
Mutations and Diseases : HGMDGNAI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNAI2
DgiDB (Drug Gene Interaction Database)GNAI2
DoCM (Curated mutations)GNAI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNAI2 (select a term)
intoGenGNAI2
Cancer3DGNAI2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139360    192605   
Orphanet
DisGeNETGNAI2
MedgenGNAI2
Genetic Testing Registry GNAI2
NextProtP04899 [Medical]
TSGene2771
GENETestsGNAI2
Target ValidationGNAI2
Huge Navigator GNAI2 [HugePedia]
snp3D : Map Gene to Disease2771
BioCentury BCIQGNAI2
ClinGenGNAI2
Clinical trials, drugs, therapy
Protein Interactions : CTD2771
Pharm GKB GenePA24347
Pharm GKB PathwaysPA154444041   PA161749006   PA2024   
Clinical trialGNAI2
Miscellaneous
canSAR (ICR)GNAI2 (select the gene name)
HarmonizomeGNAI2
DataMed IndexGNAI2
Probes
Litterature
PubMed180 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNAI2
EVEXGNAI2
GoPubMedGNAI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:12:54 CEST 2020

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