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GNAO1 (G protein subunit alpha o1)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Alias_symbol (synonym)G-ALPHA-o
Other aliasEIEE17
GNAO
HLA-DQB1
HGNC (Hugo) GNAO1
LocusID (NCBI) 2775
Atlas_Id 43279
Location 16q13  [Link to chromosome band 16q13]
Location_base_pair Starts at 56191339 and ends at 56357444 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FBRSL1 (12q24.33) / GNAO1 (16q12.2)GNAO1 (16q12.2) / FAM81A (15q22.2)GNAO1 (16q12.2) / GNAO1 (16q12.2)
HGS (17q25.3) / GNAO1 (16q12.2)NUP93 (16q13) / GNAO1 (16q12.2)TBC1D5 (3p24.3) / GNAO1 (16q12.2)
TOX3 (16q12.1) / GNAO1 (16q12.2)ZNF711 (Xq21.1) / GNAO1 (16q12.2)HGS 17q25.3 / GNAO1 16q12.2
NUP93 16q13 / GNAO1 16q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNAO1   4389
Cards
Entrez_Gene (NCBI)GNAO1  2775  G protein subunit alpha o1
AliasesEIEE17; G-ALPHA-o; GNAO; HLA-DQB1
GeneCards (Weizmann)GNAO1
Ensembl hg19 (Hinxton)ENSG00000087258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087258 [Gene_View]  chr16:56191339-56357444 [Contig_View]  GNAO1 [Vega]
ICGC DataPortalENSG00000087258
TCGA cBioPortalGNAO1
AceView (NCBI)GNAO1
Genatlas (Paris)GNAO1
WikiGenes2775
SOURCE (Princeton)GNAO1
Genetics Home Reference (NIH)GNAO1
Genomic and cartography
GoldenPath hg38 (UCSC)GNAO1  -     chr16:56191339-56357444 +  16q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNAO1  -     16q13   [Description]    (hg19-Feb_2009)
EnsemblGNAO1 - 16q13 [CytoView hg19]  GNAO1 - 16q13 [CytoView hg38]
Mapping of homologs : NCBIGNAO1 [Mapview hg19]  GNAO1 [Mapview hg38]
OMIM139311   615473   
Gene and transcription
Genbank (Entrez)AF493894 AF493895 AK056008 AK295680 AL512686
RefSeq transcript (Entrez)NM_020988 NM_138736
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNAO1
Cluster EST : UnigeneHs.644524 [ NCBI ]
CGAP (NCI)Hs.644524
Alternative Splicing GalleryENSG00000087258
Gene ExpressionGNAO1 [ NCBI-GEO ]   GNAO1 [ EBI - ARRAY_EXPRESS ]   GNAO1 [ SEEK ]   GNAO1 [ MEM ]
Gene Expression Viewer (FireBrowse)GNAO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2775
GTEX Portal (Tissue expression)GNAO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09471   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09471  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09471
Splice isoforms : SwissVarP09471
PhosPhoSitePlusP09471
Domains : Interpro (EBI)Gprotein_alpha_I    Gprotein_alpha_su    GproteinA_insert    P-loop_NTPase   
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
Conserved Domain (NCBI)GNAO1
DMDM Disease mutations2775
Blocks (Seattle)GNAO1
SuperfamilyP09471
Human Protein AtlasENSG00000087258
Peptide AtlasP09471
HPRD00757
IPIIPI00220281   IPI00398700   
Protein Interaction databases
DIP (DOE-UCLA)P09471
IntAct (EBI)P09471
FunCoupENSG00000087258
BioGRIDGNAO1
STRING (EMBL)GNAO1
ZODIACGNAO1
Ontologies - Pathways
QuickGOP09471
Ontology : AmiGOGTPase activity  GTPase activity  signal transducer activity  GTP binding  heterotrimeric G-protein complex  plasma membrane  protein folding  muscle contraction  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  dopamine receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  aging  locomotory behavior  regulation of heart contraction  dendrite  forebrain development  neuron projection development  G-protein beta/gamma-subunit complex binding  G-protein coupled serotonin receptor binding  mu-type opioid receptor binding  GTPase activating protein binding  response to cytokine  response to drug  response to hydrogen peroxide  myelin sheath  response to morphine  positive regulation of GTPase activity  cell body  metal ion binding  corticotropin-releasing hormone receptor 1 binding  negative regulation of calcium ion transport  
Ontology : EGO-EBIGTPase activity  GTPase activity  signal transducer activity  GTP binding  heterotrimeric G-protein complex  plasma membrane  protein folding  muscle contraction  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  dopamine receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  aging  locomotory behavior  regulation of heart contraction  dendrite  forebrain development  neuron projection development  G-protein beta/gamma-subunit complex binding  G-protein coupled serotonin receptor binding  mu-type opioid receptor binding  GTPase activating protein binding  response to cytokine  response to drug  response to hydrogen peroxide  myelin sheath  response to morphine  positive regulation of GTPase activity  cell body  metal ion binding  corticotropin-releasing hormone receptor 1 binding  negative regulation of calcium ion transport  
Pathways : KEGG   
NDEx NetworkGNAO1
Atlas of Cancer Signalling NetworkGNAO1
Wikipedia pathwaysGNAO1
Orthology - Evolution
OrthoDB2775
GeneTree (enSembl)ENSG00000087258
Phylogenetic Trees/Animal Genes : TreeFamGNAO1
HOVERGENP09471
HOGENOMP09471
Homologs : HomoloGeneGNAO1
Homology/Alignments : Family Browser (UCSC)GNAO1
Gene fusions - Rearrangements
Fusion : MitelmanHGS/GNAO1 [17q25.3/16q12.2]  [t(16;17)(q12;q25)]  
Fusion : MitelmanNUP93/GNAO1 [16q13/16q12.2]  [t(16;16)(q12;q13)]  
Fusion : MitelmanTOX3/GNAO1 [16q12.1/16q12.2]  [t(16;16)(q12;q12)]  
Fusion: TCGAHGS 17q25.3 GNAO1 16q12.2 LUSC
Fusion: TCGANUP93 16q13 GNAO1 16q12.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNAO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNAO1
dbVarGNAO1
ClinVarGNAO1
1000_GenomesGNAO1 
Exome Variant ServerGNAO1
ExAC (Exome Aggregation Consortium)GNAO1 (select the gene name)
Genetic variants : HAPMAP2775
Genomic Variants (DGV)GNAO1 [DGVbeta]
DECIPHERGNAO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNAO1 
Mutations
ICGC Data PortalGNAO1 
TCGA Data PortalGNAO1 
Broad Tumor PortalGNAO1
OASIS PortalGNAO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNAO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNAO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNAO1
DgiDB (Drug Gene Interaction Database)GNAO1
DoCM (Curated mutations)GNAO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNAO1 (select a term)
intoGenGNAO1
Cancer3DGNAO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139311    615473   
Orphanet889   
MedgenGNAO1
Genetic Testing Registry GNAO1
NextProtP09471 [Medical]
TSGene2775
GENETestsGNAO1
Target ValidationGNAO1
Huge Navigator GNAO1 [HugePedia]
snp3D : Map Gene to Disease2775
BioCentury BCIQGNAO1
ClinGenGNAO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2775
Chemical/Pharm GKB GenePA28771
Clinical trialGNAO1
Miscellaneous
canSAR (ICR)GNAO1 (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNAO1
EVEXGNAO1
GoPubMedGNAO1
iHOPGNAO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:35:30 CEST 2017

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