Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GNB1 (G protein subunit beta 1)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Other alias-
HGNC (Hugo) GNB1
LocusID (NCBI) 2782
Atlas_Id 40728
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1716724 and ends at 1822556 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EPCAM (2p21) / GNB1 (1p36.33)GNB1 (1p36.33) / CASP7 (10q25.3)GNB1 (1p36.33) / CCND1 (11q13.3)
GNB1 (1p36.33) / CPLX1 (4p16.3)GNB1 (1p36.33) / DAD1 (14q11.2)GNB1 (1p36.33) / DDX50 (10q22.1)
GNB1 (1p36.33) / ELF3 (1q32.1)GNB1 (1p36.33) / FANK1 (10q26.2)GNB1 (1p36.33) / GNB1 (1p36.33)
GNB1 (1p36.33) / LCP1 (13q14.13)GNB1 (1p36.33) / PEX2 (8q21.11)GNB1 (1p36.33) / RPL24 (3q12.3)
GNB1 (1p36.33) / TARDBP (1p36.22)GNB1 (1p36.33) / TRH (3q22.1)KAZN (1p36.21) / GNB1 (1p36.33)
LRRC45 (17q25.3) / GNB1 (1p36.33)LUZP1 (1p36.12) / GNB1 (1p36.33)MBP (18q23) / GNB1 (1p36.33)
MORF4L2 (Xq22.2) / GNB1 (1p36.33)NADK (1p36.33) / GNB1 (1p36.33)RABGEF1 (7q11.21) / GNB1 (1p36.33)
SNHG3 (1p35.3) / GNB1 (1p36.33)UBE2J2 (1p36.33) / GNB1 (1p36.33)ZFP14 (19q13.12) / GNB1 (1p36.33)
ZSCAN30 (18q12.2) / GNB1 (1p36.33)LRRC45 17q25.3 / GNB1 1p36.33NADK 1p36.33 / GNB1 1p36.33
UBE2J2 1p36.33 / GNB1 1p36.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNB1   4396
Cards
Entrez_Gene (NCBI)GNB1  2782  G protein subunit beta 1
Aliases
GeneCards (Weizmann)GNB1
Ensembl hg19 (Hinxton)ENSG00000078369 [Gene_View]  chr1:1716724-1822556 [Contig_View]  GNB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000078369 [Gene_View]  chr1:1716724-1822556 [Contig_View]  GNB1 [Vega]
ICGC DataPortalENSG00000078369
TCGA cBioPortalGNB1
AceView (NCBI)GNB1
Genatlas (Paris)GNB1
WikiGenes2782
SOURCE (Princeton)GNB1
Genetics Home Reference (NIH)GNB1
Genomic and cartography
GoldenPath hg19 (UCSC)GNB1  -     chr1:1716724-1822556 -  1p36.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GNB1  -     1p36.33   [Description]    (hg38-Dec_2013)
EnsemblGNB1 - 1p36.33 [CytoView hg19]  GNB1 - 1p36.33 [CytoView hg38]
Mapping of homologs : NCBIGNB1 [Mapview hg19]  GNB1 [Mapview hg38]
OMIM139380   
Gene and transcription
Genbank (Entrez)AF070597 AF070603 AF501882 AI092255 AK096614
RefSeq transcript (Entrez)NM_001282538 NM_001282539 NM_002074
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929288
Consensus coding sequences : CCDS (NCBI)GNB1
Cluster EST : UnigeneHs.721030 [ NCBI ]
CGAP (NCI)Hs.721030
Alternative Splicing GalleryENSG00000078369
Gene ExpressionGNB1 [ NCBI-GEO ]   GNB1 [ EBI - ARRAY_EXPRESS ]   GNB1 [ SEEK ]   GNB1 [ MEM ]
Gene Expression Viewer (FireBrowse)GNB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2782
GTEX Portal (Tissue expression)GNB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62873   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62873  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62873
Splice isoforms : SwissVarP62873
PhosPhoSitePlusP62873
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Gprotein_B    Guanine_nucleotide-bd_bsu    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)GNB1
DMDM Disease mutations2782
Blocks (Seattle)GNB1
PDB (SRS)4KFM    4PNK   
PDB (PDBSum)4KFM    4PNK   
PDB (IMB)4KFM    4PNK   
PDB (RSDB)4KFM    4PNK   
Structural Biology KnowledgeBase4KFM    4PNK   
SCOP (Structural Classification of Proteins)4KFM    4PNK   
CATH (Classification of proteins structures)4KFM    4PNK   
SuperfamilyP62873
Human Protein AtlasENSG00000078369
Peptide AtlasP62873
HPRD00766
IPIIPI00026268   IPI00642117   IPI00640949   IPI00640462   IPI00639998   
Protein Interaction databases
DIP (DOE-UCLA)P62873
IntAct (EBI)P62873
FunCoupENSG00000078369
BioGRIDGNB1
STRING (EMBL)GNB1
ZODIACGNB1
Ontologies - Pathways
QuickGOP62873
Ontology : AmiGOphotoreceptor inner segment  GTPase activity  signal transducer activity  protein binding  intracellular  lysosomal membrane  cytosol  heterotrimeric G-protein complex  plasma membrane  protein folding  signal transduction  adenylate cyclase-activating dopamine receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  G-protein coupled acetylcholine receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  Ras protein signal transduction  cell proliferation  cardiac muscle cell apoptotic process  membrane  rhodopsin mediated signaling pathway  platelet activation  dendrite  spectrin binding  type 1 angiotensin receptor binding  protein complex binding  photoreceptor outer segment membrane  myelin sheath  cell body  sensory perception of taste  GTPase binding  retina development in camera-type eye  extracellular exosome  cellular response to glucagon stimulus  cellular response to prostaglandin E stimulus  cellular response to hypoxia  cellular response to catecholamine stimulus  photoreceptor disc membrane  extracellular vesicle  
Ontology : EGO-EBIphotoreceptor inner segment  GTPase activity  signal transducer activity  protein binding  intracellular  lysosomal membrane  cytosol  heterotrimeric G-protein complex  plasma membrane  protein folding  signal transduction  adenylate cyclase-activating dopamine receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  G-protein coupled acetylcholine receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  Ras protein signal transduction  cell proliferation  cardiac muscle cell apoptotic process  membrane  rhodopsin mediated signaling pathway  platelet activation  dendrite  spectrin binding  type 1 angiotensin receptor binding  protein complex binding  photoreceptor outer segment membrane  myelin sheath  cell body  sensory perception of taste  GTPase binding  retina development in camera-type eye  extracellular exosome  cellular response to glucagon stimulus  cellular response to prostaglandin E stimulus  cellular response to hypoxia  cellular response to catecholamine stimulus  photoreceptor disc membrane  extracellular vesicle  
Pathways : KEGGRas signaling pathway    Chemokine signaling pathway    PI3K-Akt signaling pathway    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Taste transduction    Phototransduction    Morphine addiction    Alcoholism   
NDEx NetworkGNB1
Atlas of Cancer Signalling NetworkGNB1
Wikipedia pathwaysGNB1
Orthology - Evolution
OrthoDB2782
GeneTree (enSembl)ENSG00000078369
Phylogenetic Trees/Animal Genes : TreeFamGNB1
HOVERGENP62873
HOGENOMP62873
Homologs : HomoloGeneGNB1
Homology/Alignments : Family Browser (UCSC)GNB1
Gene fusions - Rearrangements
Fusion : MitelmanGNB1/TRH [1p36.33/3q22.1]  
Fusion : MitelmanLRRC45/GNB1 [17q25.3/1p36.33]  [t(1;17)(p36;q25)]  
Fusion : MitelmanNADK/GNB1 [1p36.33/1p36.33]  [t(1;1)(p36;p36)]  
Fusion : MitelmanUBE2J2/GNB1 [1p36.33/1p36.33]  [t(1;1)(p36;p36)]  
Fusion: TCGALRRC45 17q25.3 GNB1 1p36.33 LUAD
Fusion: TCGANADK 1p36.33 GNB1 1p36.33 HNSC LGG
Fusion: TCGAUBE2J2 1p36.33 GNB1 1p36.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNB1
dbVarGNB1
ClinVarGNB1
1000_GenomesGNB1 
Exome Variant ServerGNB1
ExAC (Exome Aggregation Consortium)GNB1 (select the gene name)
Genetic variants : HAPMAP2782
Genomic Variants (DGV)GNB1 [DGVbeta]
DECIPHER (Syndromes)1:1716724-1822556  ENSG00000078369
CONAN: Copy Number AnalysisGNB1 
Mutations
ICGC Data PortalGNB1 
TCGA Data PortalGNB1 
Broad Tumor PortalGNB1
OASIS PortalGNB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNB1
DgiDB (Drug Gene Interaction Database)GNB1
DoCM (Curated mutations)GNB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNB1 (select a term)
intoGenGNB1
Cancer3DGNB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139380   
Orphanet
MedgenGNB1
Genetic Testing Registry GNB1
NextProtP62873 [Medical]
TSGene2782
GENETestsGNB1
Huge Navigator GNB1 [HugePedia]
snp3D : Map Gene to Disease2782
BioCentury BCIQGNB1
ClinGenGNB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2782
Chemical/Pharm GKB GenePA28776
Clinical trialGNB1
Miscellaneous
canSAR (ICR)GNB1 (select the gene name)
Probes
Litterature
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNB1
EVEXGNB1
GoPubMedGNB1
iHOPGNB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:07:43 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.