Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GNB1 (G protein subunit beta 1)

Identity

Alias (NCBI)MRD42
HGNC (Hugo) GNB1
HGNC Alias nametransducin beta chain 1
 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
HGNC Previous nameguanine nucleotide binding protein (G protein), beta polypeptide 1
LocusID (NCBI) 2782
Atlas_Id 40728
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1785286 and ends at 1891087 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EPCAM (2p21) / GNB1 (1p36.33)GNB1 (1p36.33) / CASP7 (10q25.3)GNB1 (1p36.33) / CCND1 (11q13.3)
GNB1 (1p36.33) / CPLX1 (4p16.3)GNB1 (1p36.33) / DAD1 (14q11.2)GNB1 (1p36.33) / DDX50 (10q22.1)
GNB1 (1p36.33) / ELF3 (1q32.1)GNB1 (1p36.33) / FANK1 (10q26.2)GNB1 (1p36.33) / GNB1 (1p36.33)
GNB1 (1p36.33) / LCP1 (13q14.13)GNB1 (1p36.33) / PEX2 (8q21.11)GNB1 (1p36.33) / RPL24 (3q12.3)
GNB1 (1p36.33) / TARDBP (1p36.22)GNB1 (1p36.33) / TRH (3q22.1)KAZN (1p36.21) / GNB1 (1p36.33)
LRRC45 (17q25.3) / GNB1 (1p36.33)LUZP1 (1p36.12) / GNB1 (1p36.33)MBP (18q23) / GNB1 (1p36.33)
MORF4L2 (Xq22.2) / GNB1 (1p36.33)NADK (1p36.33) / GNB1 (1p36.33)RABGEF1 (7q11.21) / GNB1 (1p36.33)
SNHG3 (1p35.3) / GNB1 (1p36.33)UBE2J2 (1p36.33) / GNB1 (1p36.33)ZFP14 (19q13.12) / GNB1 (1p36.33)
ZSCAN30 (18q12.2) / GNB1 (1p36.33)LRRC45 17q25.3 / GNB1 1p36.33NADK 1p36.33 / GNB1 1p36.33
UBE2J2 1p36.33 / GNB1 1p36.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  NADK/GNB1 (1p36)
UBE2J2/GNB1 (1p36)
t(1;3)(p36;q22) GNB1/TRH
t(1;17)(p36;q25) LRRC45/GNB1


External links

Nomenclature
HGNC (Hugo)GNB1   4396
Cards
Entrez_Gene (NCBI)GNB1  2782  G protein subunit beta 1
AliasesMRD42
GeneCards (Weizmann)GNB1
Ensembl hg19 (Hinxton)ENSG00000078369 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078369 [Gene_View]  ENSG00000078369 [Sequence]  chr1:1785286-1891087 [Contig_View]  GNB1 [Vega]
ICGC DataPortalENSG00000078369
TCGA cBioPortalGNB1
AceView (NCBI)GNB1
Genatlas (Paris)GNB1
WikiGenes2782
SOURCE (Princeton)GNB1
Genetics Home Reference (NIH)GNB1
Genomic and cartography
GoldenPath hg38 (UCSC)GNB1  -     chr1:1785286-1891087 -  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNB1  -     1p36.33   [Description]    (hg19-Feb_2009)
GoldenPathGNB1 - 1p36.33 [CytoView hg19]  GNB1 - 1p36.33 [CytoView hg38]
ImmunoBaseENSG00000078369
genome Data Viewer NCBIGNB1 [Mapview hg19]  
OMIM139380   613065   616973   
Gene and transcription
Genbank (Entrez)AF070597 AF070603 AF501882 AI092255 AK096614
RefSeq transcript (Entrez)NM_001282538 NM_001282539 NM_002074
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNB1
Alternative Splicing GalleryENSG00000078369
Gene ExpressionGNB1 [ NCBI-GEO ]   GNB1 [ EBI - ARRAY_EXPRESS ]   GNB1 [ SEEK ]   GNB1 [ MEM ]
Gene Expression Viewer (FireBrowse)GNB1 [ Firebrowse - Broad ]
GenevisibleExpression of GNB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2782
GTEX Portal (Tissue expression)GNB1
Human Protein AtlasENSG00000078369-GNB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62873   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62873  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62873
Splice isoforms : SwissVarP62873
PhosPhoSitePlusP62873
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Gprotein_B    Guanine_nucleotide-bd_bsu    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)GNB1
DMDM Disease mutations2782
Blocks (Seattle)GNB1
PDB (RSDB)4KFM    4PNK    5HE0    5HE1    5HE2    5HE3    5UKK    5UKL    5UKM    5UZ7    6B3J    6CRK    6D9H    6DDE    6DDF    6E3Y    6EG8    6G79    6GDG    6M8S    6N4B    6NI3    6NIY    6OIJ    6OIK    6ORV    6OS9    6OSA    6OT0   
PDB Europe4KFM    4PNK    5HE0    5HE1    5HE2    5HE3    5UKK    5UKL    5UKM    5UZ7    6B3J    6CRK    6D9H    6DDE    6DDF    6E3Y    6EG8    6G79    6GDG    6M8S    6N4B    6NI3    6NIY    6OIJ    6OIK    6ORV    6OS9    6OSA    6OT0   
PDB (PDBSum)4KFM    4PNK    5HE0    5HE1    5HE2    5HE3    5UKK    5UKL    5UKM    5UZ7    6B3J    6CRK    6D9H    6DDE    6DDF    6E3Y    6EG8    6G79    6GDG    6M8S    6N4B    6NI3    6NIY    6OIJ    6OIK    6ORV    6OS9    6OSA    6OT0   
PDB (IMB)4KFM    4PNK    5HE0    5HE1    5HE2    5HE3    5UKK    5UKL    5UKM    5UZ7    6B3J    6CRK    6D9H    6DDE    6DDF    6E3Y    6EG8    6G79    6GDG    6M8S    6N4B    6NI3    6NIY    6OIJ    6OIK    6ORV    6OS9    6OSA    6OT0   
Structural Biology KnowledgeBase4KFM    4PNK    5HE0    5HE1    5HE2    5HE3    5UKK    5UKL    5UKM    5UZ7    6B3J    6CRK    6D9H    6DDE    6DDF    6E3Y    6EG8    6G79    6GDG    6M8S    6N4B    6NI3    6NIY    6OIJ    6OIK    6ORV    6OS9    6OSA    6OT0   
SCOP (Structural Classification of Proteins)4KFM    4PNK    5HE0    5HE1    5HE2    5HE3    5UKK    5UKL    5UKM    5UZ7    6B3J    6CRK    6D9H    6DDE    6DDF    6E3Y    6EG8    6G79    6GDG    6M8S    6N4B    6NI3    6NIY    6OIJ    6OIK    6ORV    6OS9    6OSA    6OT0   
CATH (Classification of proteins structures)4KFM    4PNK    5HE0    5HE1    5HE2    5HE3    5UKK    5UKL    5UKM    5UZ7    6B3J    6CRK    6D9H    6DDE    6DDF    6E3Y    6EG8    6G79    6GDG    6M8S    6N4B    6NI3    6NIY    6OIJ    6OIK    6ORV    6OS9    6OSA    6OT0   
SuperfamilyP62873
Human Protein Atlas [tissue]ENSG00000078369-GNB1 [tissue]
Peptide AtlasP62873
HPRD00766
IPIIPI00026268   IPI00642117   IPI00640949   IPI00640462   IPI00639998   
Protein Interaction databases
DIP (DOE-UCLA)P62873
IntAct (EBI)P62873
FunCoupENSG00000078369
BioGRIDGNB1
STRING (EMBL)GNB1
ZODIACGNB1
Ontologies - Pathways
QuickGOP62873
Ontology : AmiGOphotoreceptor inner segment  GTPase activity  protein binding  cytoplasm  lysosomal membrane  cytosol  heterotrimeric G-protein complex  heterotrimeric G-protein complex  plasma membrane  protein folding  signal transduction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  adenylate cyclase-activating dopamine receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  G protein-coupled acetylcholine receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  Ras protein signal transduction  cell proliferation  cardiac muscle cell apoptotic process  membrane  rhodopsin mediated signaling pathway  platelet activation  dendrite  spectrin binding  G-protein gamma-subunit binding  photoreceptor outer segment membrane  cell body  protein-containing complex binding  synapse  alkylglycerophosphoethanolamine phosphodiesterase activity  sensory perception of taste  GTPase binding  retina development in camera-type eye  extracellular exosome  cellular response to prostaglandin E stimulus  cellular response to hypoxia  cellular response to catecholamine stimulus  photoreceptor disc membrane  extracellular vesicle  
Ontology : EGO-EBIphotoreceptor inner segment  GTPase activity  protein binding  cytoplasm  lysosomal membrane  cytosol  heterotrimeric G-protein complex  heterotrimeric G-protein complex  plasma membrane  protein folding  signal transduction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  adenylate cyclase-activating dopamine receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  G protein-coupled acetylcholine receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  Ras protein signal transduction  cell proliferation  cardiac muscle cell apoptotic process  membrane  rhodopsin mediated signaling pathway  platelet activation  dendrite  spectrin binding  G-protein gamma-subunit binding  photoreceptor outer segment membrane  cell body  protein-containing complex binding  synapse  alkylglycerophosphoethanolamine phosphodiesterase activity  sensory perception of taste  GTPase binding  retina development in camera-type eye  extracellular exosome  cellular response to prostaglandin E stimulus  cellular response to hypoxia  cellular response to catecholamine stimulus  photoreceptor disc membrane  extracellular vesicle  
Pathways : KEGGRas signaling pathway    Chemokine signaling pathway    PI3K-Akt signaling pathway    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Taste transduction    Phototransduction    Morphine addiction    Alcoholism   
NDEx NetworkGNB1
Atlas of Cancer Signalling NetworkGNB1
Wikipedia pathwaysGNB1
Orthology - Evolution
OrthoDB2782
GeneTree (enSembl)ENSG00000078369
Phylogenetic Trees/Animal Genes : TreeFamGNB1
HOGENOMP62873
Homologs : HomoloGeneGNB1
Homology/Alignments : Family Browser (UCSC)GNB1
Gene fusions - Rearrangements
Fusion : MitelmanGNB1/TRH [1p36.33/3q22.1]  
Fusion : MitelmanLRRC45/GNB1 [17q25.3/1p36.33]  
Fusion : MitelmanNADK/GNB1 [1p36.33/1p36.33]  
Fusion : MitelmanUBE2J2/GNB1 [1p36.33/1p36.33]  
Fusion PortalLRRC45 17q25.3 GNB1 1p36.33 LUAD
Fusion PortalNADK 1p36.33 GNB1 1p36.33 HNSC LGG
Fusion PortalUBE2J2 1p36.33 GNB1 1p36.33 BRCA
Fusion : QuiverGNB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNB1
dbVarGNB1
ClinVarGNB1
1000_GenomesGNB1 
Exome Variant ServerGNB1
GNOMAD BrowserENSG00000078369
Varsome BrowserGNB1
Genetic variants : HAPMAP2782
Genomic Variants (DGV)GNB1 [DGVbeta]
DECIPHERGNB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNB1 
Mutations
ICGC Data PortalGNB1 
TCGA Data PortalGNB1 
Broad Tumor PortalGNB1
OASIS PortalGNB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGNB1
Mutations and Diseases : HGMDGNB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNB1
DgiDB (Drug Gene Interaction Database)GNB1
DoCM (Curated mutations)GNB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNB1 (select a term)
intoGenGNB1
Cancer3DGNB1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139380    613065    616973   
Orphanet
DisGeNETGNB1
MedgenGNB1
Genetic Testing Registry GNB1
NextProtP62873 [Medical]
TSGene2782
GENETestsGNB1
Target ValidationGNB1
Huge Navigator GNB1 [HugePedia]
snp3D : Map Gene to Disease2782
BioCentury BCIQGNB1
ClinGenGNB1
Clinical trials, drugs, therapy
Protein Interactions : CTD2782
Pharm GKB GenePA28776
Pharm GKB PathwaysPA162355621   PA2024   
Clinical trialGNB1
Miscellaneous
canSAR (ICR)GNB1 (select the gene name)
HarmonizomeGNB1
DataMed IndexGNB1
Probes
Litterature
PubMed179 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNB1
EVEXGNB1
GoPubMedGNB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:15:05 CEST 2020

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