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GNB1L (G protein subunit beta 1 like)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Alias_symbol (synonym)GY2
WDR14
Other aliasDGCRK3
FKSG1
WDVCF
HGNC (Hugo) GNB1L
LocusID (NCBI) 54584
Atlas_Id 40729
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 19788411 and ends at 19854939 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GNB1L (22q11.21) / CRTC3 (15q26.1)GNB1L (22q11.21) / GNB1L (22q11.21)GNB1L (22q11.21) / SEPT5 (22q11.21)
MED15 (22q11.21) / GNB1L (22q11.21)MED15 22q11.21 / GNB1L 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  MED15/GNB1L (22q11)

External links

Nomenclature
HGNC (Hugo)GNB1L   4397
Cards
Entrez_Gene (NCBI)GNB1L  54584  G protein subunit beta 1 like
AliasesDGCRK3; FKSG1; GY2; WDR14; 
WDVCF
GeneCards (Weizmann)GNB1L
Ensembl hg19 (Hinxton)ENSG00000185838 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185838 [Gene_View]  ENSG00000185838 [Sequence]  chr22:19788411-19854939 [Contig_View]  GNB1L [Vega]
ICGC DataPortalENSG00000185838
TCGA cBioPortalGNB1L
AceView (NCBI)GNB1L
Genatlas (Paris)GNB1L
WikiGenes54584
SOURCE (Princeton)GNB1L
Genetics Home Reference (NIH)GNB1L
Genomic and cartography
GoldenPath hg38 (UCSC)GNB1L  -     chr22:19788411-19854939 -  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNB1L  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblGNB1L - 22q11.21 [CytoView hg19]  GNB1L - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIGNB1L [Mapview hg19]  GNB1L [Mapview hg38]
OMIM610778   
Gene and transcription
Genbank (Entrez)AB051432 AF238328 AF301895 AY007378 BC012060
RefSeq transcript (Entrez)NM_053004
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNB1L
Cluster EST : UnigeneHs.105642 [ NCBI ]
CGAP (NCI)Hs.105642
Alternative Splicing GalleryENSG00000185838
Gene ExpressionGNB1L [ NCBI-GEO ]   GNB1L [ EBI - ARRAY_EXPRESS ]   GNB1L [ SEEK ]   GNB1L [ MEM ]
Gene Expression Viewer (FireBrowse)GNB1L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54584
GTEX Portal (Tissue expression)GNB1L
Human Protein AtlasENSG00000185838-GNB1L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYB4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYB4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYB4
Splice isoforms : SwissVarQ9BYB4
PhosPhoSitePlusQ9BYB4
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)GNB1L
DMDM Disease mutations54584
Blocks (Seattle)GNB1L
SuperfamilyQ9BYB4
Human Protein Atlas [tissue]ENSG00000185838-GNB1L [tissue]
Peptide AtlasQ9BYB4
HPRD13591
IPIIPI00107339   IPI00218734   IPI00879333   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYB4
IntAct (EBI)Q9BYB4
FunCoupENSG00000185838
BioGRIDGNB1L
STRING (EMBL)GNB1L
ZODIACGNB1L
Ontologies - Pathways
QuickGOQ9BYB4
Ontology : AmiGOmolecular_function  cytoplasm  G-protein coupled receptor signaling pathway  cytoplasmic side of plasma membrane  social behavior  intracellular signal transduction  
Ontology : EGO-EBImolecular_function  cytoplasm  G-protein coupled receptor signaling pathway  cytoplasmic side of plasma membrane  social behavior  intracellular signal transduction  
NDEx NetworkGNB1L
Atlas of Cancer Signalling NetworkGNB1L
Wikipedia pathwaysGNB1L
Orthology - Evolution
OrthoDB54584
GeneTree (enSembl)ENSG00000185838
Phylogenetic Trees/Animal Genes : TreeFamGNB1L
HOVERGENQ9BYB4
HOGENOMQ9BYB4
Homologs : HomoloGeneGNB1L
Homology/Alignments : Family Browser (UCSC)GNB1L
Gene fusions - Rearrangements
Fusion : MitelmanMED15/GNB1L [22q11.21/22q11.21]  [t(22;22)(q11;q11)]  
Fusion PortalMED15 22q11.21 GNB1L 22q11.21 BLCA
Fusion : QuiverGNB1L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNB1L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNB1L
dbVarGNB1L
ClinVarGNB1L
1000_GenomesGNB1L 
Exome Variant ServerGNB1L
ExAC (Exome Aggregation Consortium)ENSG00000185838
GNOMAD BrowserENSG00000185838
Varsome BrowserGNB1L
Genetic variants : HAPMAP54584
Genomic Variants (DGV)GNB1L [DGVbeta]
DECIPHERGNB1L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNB1L 
Mutations
ICGC Data PortalGNB1L 
TCGA Data PortalGNB1L 
Broad Tumor PortalGNB1L
OASIS PortalGNB1L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNB1L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNB1L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNB1L
DgiDB (Drug Gene Interaction Database)GNB1L
DoCM (Curated mutations)GNB1L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNB1L (select a term)
intoGenGNB1L
Cancer3DGNB1L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610778   
Orphanet
DisGeNETGNB1L
MedgenGNB1L
Genetic Testing Registry GNB1L
NextProtQ9BYB4 [Medical]
TSGene54584
GENETestsGNB1L
Target ValidationGNB1L
Huge Navigator GNB1L [HugePedia]
snp3D : Map Gene to Disease54584
BioCentury BCIQGNB1L
ClinGenGNB1L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54584
Chemical/Pharm GKB GenePA28777
Clinical trialGNB1L
Miscellaneous
canSAR (ICR)GNB1L (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNB1L
EVEXGNB1L
GoPubMedGNB1L
iHOPGNB1L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:25:08 CEST 2018
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