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GNB2 (G protein subunit beta 2)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Other alias-
HGNC (Hugo) GNB2
LocusID (NCBI) 2783
Atlas_Id 43284
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100673740 and ends at 100679169 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATG7 (3p25.3) / GNB2 (7q22.1)GNB2 (7q22.1) / CTSD (11p15.5)GNB2 (7q22.1) / GNB2 (7q22.1)
GNB2 (7q22.1) / RPS4X (Xq13.1)TSPAN14 (10q23.1) / GNB2 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNB2   4398
Cards
Entrez_Gene (NCBI)GNB2  2783  G protein subunit beta 2
Aliases
GeneCards (Weizmann)GNB2
Ensembl hg19 (Hinxton)ENSG00000172354 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172354 [Gene_View]  chr7:100673740-100679169 [Contig_View]  GNB2 [Vega]
ICGC DataPortalENSG00000172354
TCGA cBioPortalGNB2
AceView (NCBI)GNB2
Genatlas (Paris)GNB2
WikiGenes2783
SOURCE (Princeton)GNB2
Genetics Home Reference (NIH)GNB2
Genomic and cartography
GoldenPath hg38 (UCSC)GNB2  -     chr7:100673740-100679169 +  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNB2  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblGNB2 - 7q22.1 [CytoView hg19]  GNB2 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIGNB2 [Mapview hg19]  GNB2 [Mapview hg38]
OMIM139390   
Gene and transcription
Genbank (Entrez)AF064853 AF501883 AK056750 AK291592 AL535249
RefSeq transcript (Entrez)NM_005273
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNB2
Cluster EST : UnigeneHs.185172 [ NCBI ]
CGAP (NCI)Hs.185172
Alternative Splicing GalleryENSG00000172354
Gene ExpressionGNB2 [ NCBI-GEO ]   GNB2 [ EBI - ARRAY_EXPRESS ]   GNB2 [ SEEK ]   GNB2 [ MEM ]
Gene Expression Viewer (FireBrowse)GNB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2783
GTEX Portal (Tissue expression)GNB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62879   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62879  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62879
Splice isoforms : SwissVarP62879
PhosPhoSitePlusP62879
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Gprotein_B    Guanine_nucleotide-bd_bsu    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)GNB2
DMDM Disease mutations2783
Blocks (Seattle)GNB2
SuperfamilyP62879
Human Protein AtlasENSG00000172354
Peptide AtlasP62879
HPRD11820
IPIIPI00003348   IPI00790302   IPI00790896   IPI00797969   IPI00925530   IPI00924758   
Protein Interaction databases
DIP (DOE-UCLA)P62879
IntAct (EBI)P62879
FunCoupENSG00000172354
BioGRIDGNB2
STRING (EMBL)GNB2
ZODIACGNB2
Ontologies - Pathways
QuickGOP62879
Ontology : AmiGOGTPase activity  signal transducer activity  calcium channel regulator activity  protein binding  extracellular space  lysosomal membrane  cytosol  plasma membrane  focal adhesion  protein folding  G-protein coupled receptor signaling pathway  membrane  vesicle  protein complex binding  myelin sheath  protein complex  cell body  perinuclear region of cytoplasm  GTPase binding  regulation of molecular function  extracellular exosome  cellular response to glucagon stimulus  
Ontology : EGO-EBIGTPase activity  signal transducer activity  calcium channel regulator activity  protein binding  extracellular space  lysosomal membrane  cytosol  plasma membrane  focal adhesion  protein folding  G-protein coupled receptor signaling pathway  membrane  vesicle  protein complex binding  myelin sheath  protein complex  cell body  perinuclear region of cytoplasm  GTPase binding  regulation of molecular function  extracellular exosome  cellular response to glucagon stimulus  
Pathways : KEGG   
NDEx NetworkGNB2
Atlas of Cancer Signalling NetworkGNB2
Wikipedia pathwaysGNB2
Orthology - Evolution
OrthoDB2783
GeneTree (enSembl)ENSG00000172354
Phylogenetic Trees/Animal Genes : TreeFamGNB2
HOVERGENP62879
HOGENOMP62879
Homologs : HomoloGeneGNB2
Homology/Alignments : Family Browser (UCSC)GNB2
Gene fusions - Rearrangements
Fusion : MitelmanGNB2/CTSD [7q22.1/11p15.5]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNB2
dbVarGNB2
ClinVarGNB2
1000_GenomesGNB2 
Exome Variant ServerGNB2
ExAC (Exome Aggregation Consortium)GNB2 (select the gene name)
Genetic variants : HAPMAP2783
Genomic Variants (DGV)GNB2 [DGVbeta]
DECIPHERGNB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNB2 
Mutations
ICGC Data PortalGNB2 
TCGA Data PortalGNB2 
Broad Tumor PortalGNB2
OASIS PortalGNB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNB2
DgiDB (Drug Gene Interaction Database)GNB2
DoCM (Curated mutations)GNB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNB2 (select a term)
intoGenGNB2
Cancer3DGNB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139390   
Orphanet
MedgenGNB2
Genetic Testing Registry GNB2
NextProtP62879 [Medical]
TSGene2783
GENETestsGNB2
Target ValidationGNB2
Huge Navigator GNB2 [HugePedia]
snp3D : Map Gene to Disease2783
BioCentury BCIQGNB2
ClinGenGNB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2783
Chemical/Pharm GKB GenePA28778
Clinical trialGNB2
Miscellaneous
canSAR (ICR)GNB2 (select the gene name)
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNB2
EVEXGNB2
GoPubMedGNB2
iHOPGNB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:10:06 CEST 2017

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