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GNB4 (G protein subunit beta 4)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Other aliasCMTD1F
HGNC (Hugo) GNB4
LocusID (NCBI) 59345
Atlas_Id 43287
Location 3q26.33  [Link to chromosome band 3q26]
Location_base_pair Starts at 179396088 and ends at 179451583 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SERPINB13 (18q21.33) / GNB4 (3q26.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNB4   20731
Cards
Entrez_Gene (NCBI)GNB4  59345  G protein subunit beta 4
AliasesCMTD1F
GeneCards (Weizmann)GNB4
Ensembl hg19 (Hinxton)ENSG00000114450 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114450 [Gene_View]  chr3:179396088-179451583 [Contig_View]  GNB4 [Vega]
ICGC DataPortalENSG00000114450
TCGA cBioPortalGNB4
AceView (NCBI)GNB4
Genatlas (Paris)GNB4
WikiGenes59345
SOURCE (Princeton)GNB4
Genetics Home Reference (NIH)GNB4
Genomic and cartography
GoldenPath hg38 (UCSC)GNB4  -     chr3:179396088-179451583 -  3q26.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNB4  -     3q26.33   [Description]    (hg19-Feb_2009)
EnsemblGNB4 - 3q26.33 [CytoView hg19]  GNB4 - 3q26.33 [CytoView hg38]
Mapping of homologs : NCBIGNB4 [Mapview hg19]  GNB4 [Mapview hg38]
OMIM610863   615185   
Gene and transcription
Genbank (Entrez)AF300648 AK001890 AK022599 AK091332 AK290571
RefSeq transcript (Entrez)NM_021629
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNB4
Cluster EST : UnigeneHs.173030 [ NCBI ]
CGAP (NCI)Hs.173030
Alternative Splicing GalleryENSG00000114450
Gene ExpressionGNB4 [ NCBI-GEO ]   GNB4 [ EBI - ARRAY_EXPRESS ]   GNB4 [ SEEK ]   GNB4 [ MEM ]
Gene Expression Viewer (FireBrowse)GNB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59345
GTEX Portal (Tissue expression)GNB4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAV0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAV0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAV0
Splice isoforms : SwissVarQ9HAV0
PhosPhoSitePlusQ9HAV0
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Gprotein_B    Guanine_nucleotide-bd_bsu    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)GNB4
DMDM Disease mutations59345
Blocks (Seattle)GNB4
SuperfamilyQ9HAV0
Human Protein AtlasENSG00000114450
Peptide AtlasQ9HAV0
HPRD09973
IPIIPI00012451   IPI00946384   IPI00946201   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAV0
IntAct (EBI)Q9HAV0
FunCoupENSG00000114450
BioGRIDGNB4
STRING (EMBL)GNB4
ZODIACGNB4
Ontologies - Pathways
QuickGOQ9HAV0
Ontology : AmiGOsignal transducer activity  lysosomal membrane  cytosol  plasma membrane  protein folding  signal transduction  substantia nigra development  protein complex binding  myelin sheath  extracellular exosome  cellular response to glucagon stimulus  
Ontology : EGO-EBIsignal transducer activity  lysosomal membrane  cytosol  plasma membrane  protein folding  signal transduction  substantia nigra development  protein complex binding  myelin sheath  extracellular exosome  cellular response to glucagon stimulus  
Pathways : KEGG   
NDEx NetworkGNB4
Atlas of Cancer Signalling NetworkGNB4
Wikipedia pathwaysGNB4
Orthology - Evolution
OrthoDB59345
GeneTree (enSembl)ENSG00000114450
Phylogenetic Trees/Animal Genes : TreeFamGNB4
HOVERGENQ9HAV0
HOGENOMQ9HAV0
Homologs : HomoloGeneGNB4
Homology/Alignments : Family Browser (UCSC)GNB4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNB4
dbVarGNB4
ClinVarGNB4
1000_GenomesGNB4 
Exome Variant ServerGNB4
ExAC (Exome Aggregation Consortium)GNB4 (select the gene name)
Genetic variants : HAPMAP59345
Genomic Variants (DGV)GNB4 [DGVbeta]
DECIPHERGNB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNB4 
Mutations
ICGC Data PortalGNB4 
TCGA Data PortalGNB4 
Broad Tumor PortalGNB4
OASIS PortalGNB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNB4
DgiDB (Drug Gene Interaction Database)GNB4
DoCM (Curated mutations)GNB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNB4 (select a term)
intoGenGNB4
Cancer3DGNB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610863    615185   
Orphanet22097   
MedgenGNB4
Genetic Testing Registry GNB4
NextProtQ9HAV0 [Medical]
TSGene59345
GENETestsGNB4
Huge Navigator GNB4 [HugePedia]
snp3D : Map Gene to Disease59345
BioCentury BCIQGNB4
ClinGenGNB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD59345
Chemical/Pharm GKB GenePA134864200
Clinical trialGNB4
Miscellaneous
canSAR (ICR)GNB4 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNB4
EVEXGNB4
GoPubMedGNB4
iHOPGNB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:17:31 CEST 2017

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