GNB5 (G protein subunit beta 5)

2006-10-01  

Identity

HGNC
LOCATION
15q21.2
LOCUSID
ALIAS
GB5,IDDCA,LADCI,gbeta5
FUSION GENES

Other Information

Locus ID:

NCBI: 10681
MIM: 604447
HGNC: 4401
Ensembl: ENSG00000069966

Variants:

dbSNP: 10681
ClinVar: 10681
TCGA: ENSG00000069966
COSMIC: GNB5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069966ENST00000261837O14775
ENSG00000069966ENST00000261837A0A024R5V3
ENSG00000069966ENST00000358784O14775
ENSG00000069966ENST00000358784A0A024R5R9
ENSG00000069966ENST00000396335O14775
ENSG00000069966ENST00000558519H0YLU1
ENSG00000069966ENST00000560116Q96F32
ENSG00000069966ENST00000561313H0YNW7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Pathways in cancerKEGGhsa05200
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cholinergic synapseKEGGhsa04725
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Presynaptic function of Kainate receptorsREACTOMER-HSA-500657
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Prostacyclin signalling through prostacyclin receptorREACTOMER-HSA-392851
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 12REACTOMER-HSA-392170
ADP signalling through P2Y purinoceptor 1REACTOMER-HSA-418592
Thromboxane signalling through TP receptorREACTOMER-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
G-protein beta:gamma signallingREACTOMER-HSA-397795
G beta:gamma signalling through PI3KgammaREACTOMER-HSA-392451
G beta:gamma signalling through PLC betaREACTOMER-HSA-418217
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Visual phototransductionREACTOMER-HSA-2187338
The phototransduction cascadeREACTOMER-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascadeREACTOMER-HSA-2514859
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Aquaporin-mediated transportREACTOMER-HSA-445717
Vasopressin regulates renal water homeostasis via AquaporinsREACTOMER-HSA-432040
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretionREACTOMER-HSA-400042
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180942592007Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells.53
168679772006R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.44
215119472011Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors.15
275235992016GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.14
193767732009Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.11
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.6
308649482019Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.4
316313442019The epileptology of GNB5 encephalopathy.4
251624042014G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization.3
305402502018Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.3

Citation

Dessen P

GNB5 (G protein subunit beta 5)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43288/gnb5