Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GNB5 (G protein subunit beta 5)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Alias_symbol (synonym)GB5
Other aliasIDDCA
LADCI
HGNC (Hugo) GNB5
LocusID (NCBI) 10681
Atlas_Id 43288
Location 15q21.2  [Link to chromosome band 15q21]
Location_base_pair Starts at 52120926 and ends at 52179965 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GNB5 (15q21.2) / PDE6D (2q37.1)GNB5 (15q21.2) / RBM15 (1p13.3)GNB5 (15q21.2) / RGS1 (1q31.2)
NEMF (14q21.3) / GNB5 (15q21.2)SEPT6 (Xq24) / GNB5 (15q21.2)GNB5 15q21.2 / PDE6D 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNB5   4401
Cards
Entrez_Gene (NCBI)GNB5  10681  G protein subunit beta 5
AliasesGB5; IDDCA; LADCI
GeneCards (Weizmann)GNB5
Ensembl hg19 (Hinxton)ENSG00000069966 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069966 [Gene_View]  chr15:52120926-52179965 [Contig_View]  GNB5 [Vega]
ICGC DataPortalENSG00000069966
TCGA cBioPortalGNB5
AceView (NCBI)GNB5
Genatlas (Paris)GNB5
WikiGenes10681
SOURCE (Princeton)GNB5
Genetics Home Reference (NIH)GNB5
Genomic and cartography
GoldenPath hg38 (UCSC)GNB5  -     chr15:52120926-52179965 -  15q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNB5  -     15q21.2   [Description]    (hg19-Feb_2009)
EnsemblGNB5 - 15q21.2 [CytoView hg19]  GNB5 - 15q21.2 [CytoView hg38]
Mapping of homologs : NCBIGNB5 [Mapview hg19]  GNB5 [Mapview hg38]
OMIM604447   617173   617182   
Gene and transcription
Genbank (Entrez)AF017656 AF300650 AF501885 AK094776 AK125702
RefSeq transcript (Entrez)NM_006578 NM_016194
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNB5
Cluster EST : UnigeneHs.155090 [ NCBI ]
CGAP (NCI)Hs.155090
Alternative Splicing GalleryENSG00000069966
Gene ExpressionGNB5 [ NCBI-GEO ]   GNB5 [ EBI - ARRAY_EXPRESS ]   GNB5 [ SEEK ]   GNB5 [ MEM ]
Gene Expression Viewer (FireBrowse)GNB5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10681
GTEX Portal (Tissue expression)GNB5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14775
Splice isoforms : SwissVarO14775
PhosPhoSitePlusO14775
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Gprotein_B    Guanine_nucleotide-bd_bsu    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)GNB5
DMDM Disease mutations10681
Blocks (Seattle)GNB5
SuperfamilyO14775
Human Protein AtlasENSG00000069966
Peptide AtlasO14775
HPRD09191
IPIIPI00151607   IPI00745232   IPI00967497   IPI01014336   IPI00386609   
Protein Interaction databases
DIP (DOE-UCLA)O14775
IntAct (EBI)O14775
FunCoupENSG00000069966
BioGRIDGNB5
STRING (EMBL)GNB5
ZODIACGNB5
Ontologies - Pathways
QuickGOO14775
Ontology : AmiGOGTPase activity  signal transducer activity  GTPase activator activity  GTPase activator activity  protein binding  cytosol  cytosol  protein folding  signal transduction  dopamine receptor signaling pathway  membrane  G-protein gamma-subunit binding  positive regulation of GTPase activity  chaperone binding  negative regulation of voltage-gated calcium channel activity  GTPase activator complex  
Ontology : EGO-EBIGTPase activity  signal transducer activity  GTPase activator activity  GTPase activator activity  protein binding  cytosol  cytosol  protein folding  signal transduction  dopamine receptor signaling pathway  membrane  G-protein gamma-subunit binding  positive regulation of GTPase activity  chaperone binding  negative regulation of voltage-gated calcium channel activity  GTPase activator complex  
Pathways : KEGG   
NDEx NetworkGNB5
Atlas of Cancer Signalling NetworkGNB5
Wikipedia pathwaysGNB5
Orthology - Evolution
OrthoDB10681
GeneTree (enSembl)ENSG00000069966
Phylogenetic Trees/Animal Genes : TreeFamGNB5
HOVERGENO14775
HOGENOMO14775
Homologs : HomoloGeneGNB5
Homology/Alignments : Family Browser (UCSC)GNB5
Gene fusions - Rearrangements
Fusion : MitelmanGNB5/PDE6D [15q21.2/2q37.1]  
Fusion: TCGAGNB5 15q21.2 PDE6D 2q37.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNB5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNB5
dbVarGNB5
ClinVarGNB5
1000_GenomesGNB5 
Exome Variant ServerGNB5
ExAC (Exome Aggregation Consortium)GNB5 (select the gene name)
Genetic variants : HAPMAP10681
Genomic Variants (DGV)GNB5 [DGVbeta]
DECIPHERGNB5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNB5 
Mutations
ICGC Data PortalGNB5 
TCGA Data PortalGNB5 
Broad Tumor PortalGNB5
OASIS PortalGNB5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNB5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNB5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNB5
DgiDB (Drug Gene Interaction Database)GNB5
DoCM (Curated mutations)GNB5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNB5 (select a term)
intoGenGNB5
Cancer3DGNB5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604447    617173    617182   
Orphanet
MedgenGNB5
Genetic Testing Registry GNB5
NextProtO14775 [Medical]
TSGene10681
GENETestsGNB5
Target ValidationGNB5
Huge Navigator GNB5 [HugePedia]
snp3D : Map Gene to Disease10681
BioCentury BCIQGNB5
ClinGenGNB5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10681
Chemical/Pharm GKB GenePA28780
Clinical trialGNB5
Miscellaneous
canSAR (ICR)GNB5 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNB5
EVEXGNB5
GoPubMedGNB5
iHOPGNB5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:35:32 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.