Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase)

Identity

Other namesDMRV
GLCNE
IBM2
NM
Uae1
HGNC (Hugo) GNE
LocusID (NCBI) 10020
Atlas_Id 40730
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 36214439 and ends at 36277053 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
APTX (9p21.1) / GNE (9p13.3)GNE (9p13.3) / COL1A2 (7q21.3)GNE (9p13.3) / ERP27 (12p12.3)
GNE (9p13.3) / GNE (9p13.3)GNE (9p13.3) / RNF38 (9p13.2)GNE (9p13.3) / RPA3 (7p21.3)
KIF24 (9p13.3) / GNE (9p13.3)APTX 9p21.1 / GNE 9p13.3GNE 9p13.3 / ERP27 12p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNE   23657
Cards
Entrez_Gene (NCBI)GNE  10020  glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
AliasesDMRV; GLCNE; IBM2; NM; 
Uae1
GeneCards (Weizmann)GNE
Ensembl hg19 (Hinxton)ENSG00000159921 [Gene_View]  chr9:36214439-36277053 [Contig_View]  GNE [Vega]
Ensembl hg38 (Hinxton)ENSG00000159921 [Gene_View]  chr9:36214439-36277053 [Contig_View]  GNE [Vega]
ICGC DataPortalENSG00000159921
TCGA cBioPortalGNE
AceView (NCBI)GNE
Genatlas (Paris)GNE
WikiGenes10020
SOURCE (Princeton)GNE
Genomic and cartography
GoldenPath hg19 (UCSC)GNE  -     chr9:36214439-36277053 -  9p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GNE  -     9p13.3   [Description]    (hg38-Dec_2013)
EnsemblGNE - 9p13.3 [CytoView hg19]  GNE - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBIGNE [Mapview hg19]  GNE [Mapview hg38]
OMIM269921   600737   603824   605820   
Gene and transcription
Genbank (Entrez)AF051852 AF155663 AJ238764 AK295562 AK296687
RefSeq transcript (Entrez)NM_001128227 NM_001190383 NM_001190384 NM_001190388 NM_005476
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_008246 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)GNE
Cluster EST : UnigeneHs.5920 [ NCBI ]
CGAP (NCI)Hs.5920
Alternative Splicing GalleryENSG00000159921
Gene ExpressionGNE [ NCBI-GEO ]   GNE [ EBI - ARRAY_EXPRESS ]   GNE [ SEEK ]   GNE [ MEM ]
Gene Expression Viewer (FireBrowse)GNE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10020
GTEX Portal (Tissue expression)GNE
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y223 (Uniprot)
NextProtQ9Y223  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y223
Splice isoforms : SwissVarQ9Y223 (Swissvar)
Catalytic activity : Enzyme3.2.1.183 [ Enzyme-Expasy ]   3.2.1.1833.2.1.183 [ IntEnz-EBI ]   3.2.1.183 [ BRENDA ]   3.2.1.183 [ KEGG ]   
PhosPhoSitePlusQ9Y223
Domains : Interpro (EBI)ROK    UDP-GlcNAc_Epase    UDP_GlcNAc_Epimerase_2_dom   
Domain families : Pfam (Sanger)Epimerase_2 (PF02350)    ROK (PF00480)   
Domain families : Pfam (NCBI)pfam02350    pfam00480   
DMDM Disease mutations10020
Blocks (Seattle)GNE
PDB (SRS)2YHW    2YHY    2YI1    3EO3   
PDB (PDBSum)2YHW    2YHY    2YI1    3EO3   
PDB (IMB)2YHW    2YHY    2YI1    3EO3   
PDB (RSDB)2YHW    2YHY    2YI1    3EO3   
Structural Biology KnowledgeBase2YHW    2YHY    2YI1    3EO3   
SCOP (Structural Classification of Proteins)2YHW    2YHY    2YI1    3EO3   
CATH (Classification of proteins structures)2YHW    2YHY    2YI1    3EO3   
SuperfamilyQ9Y223
Human Protein AtlasENSG00000159921
Peptide AtlasQ9Y223
HPRD04825
IPIIPI00023162   IPI00896504   IPI01018963   IPI00982551   IPI00922266   IPI00867674   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y223
IntAct (EBI)Q9Y223
FunCoupENSG00000159921
BioGRIDGNE
STRING (EMBL)GNE
ZODIACGNE
Ontologies - Pathways
QuickGOQ9Y223
Ontology : AmiGOhydrolase activity, hydrolyzing O-glycosyl compounds  protein binding  ATP binding  cytoplasm  cytosol  N-acetylglucosamine biosynthetic process  UDP-N-acetylglucosamine metabolic process  N-acetylneuraminate metabolic process  cell adhesion  UDP-N-acetylglucosamine 2-epimerase activity  N-acylmannosamine kinase activity  carbohydrate phosphorylation  metal ion binding  
Ontology : EGO-EBIhydrolase activity, hydrolyzing O-glycosyl compounds  protein binding  ATP binding  cytoplasm  cytosol  N-acetylglucosamine biosynthetic process  UDP-N-acetylglucosamine metabolic process  N-acetylneuraminate metabolic process  cell adhesion  UDP-N-acetylglucosamine 2-epimerase activity  N-acylmannosamine kinase activity  carbohydrate phosphorylation  metal ion binding  
Pathways : KEGGAmino sugar and nucleotide sugar metabolism   
NDEx NetworkGNE
Atlas of Cancer Signalling NetworkGNE
Wikipedia pathwaysGNE
Orthology - Evolution
OrthoDB10020
GeneTree (enSembl)ENSG00000159921
Phylogenetic Trees/Animal Genes : TreeFamGNE
Homologs : HomoloGeneGNE
Homology/Alignments : Family Browser (UCSC)GNE
Gene fusions - Rearrangements
Fusion: TCGAAPTX 9p21.1 GNE 9p13.3 BRCA
Fusion: TCGAGNE 9p13.3 ERP27 12p12.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerGNE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNE
dbVarGNE
ClinVarGNE
1000_GenomesGNE 
Exome Variant ServerGNE
ExAC (Exome Aggregation Consortium)GNE (select the gene name)
Genetic variants : HAPMAP10020
Genomic Variants (DGV)GNE [DGVbeta]
Mutations
ICGC Data PortalGNE 
TCGA Data PortalGNE 
Broad Tumor PortalGNE
OASIS PortalGNE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNE 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNE
DgiDB (Drug Gene Interaction Database)GNE
DoCM (Curated mutations)GNE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNE (select a term)
intoGenGNE
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:36214439-36277053  ENSG00000159921
CONAN: Copy Number AnalysisGNE 
Mutations and Diseases : HGMDGNE
OMIM269921    600737    603824    605820   
MedgenGNE
Genetic Testing Registry GNE
NextProtQ9Y223 [Medical]
TSGene10020
GENETestsGNE
Huge Navigator GNE [HugePedia]
snp3D : Map Gene to Disease10020
BioCentury BCIQGNE
ClinGenGNE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10020
Chemical/Pharm GKB GenePA134987566
Clinical trialGNE
Miscellaneous
canSAR (ICR)GNE (select the gene name)
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNE
EVEXGNE
GoPubMedGNE
iHOPGNE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:51:13 CEST 2016

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