GNG2 (G protein subunit gamma 2)

2006-10-01  

Identity

HGNC
LOCATION
14q22.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 54331
MIM: 606981
HGNC: 4404
Ensembl: ENSG00000186469

Variants:

dbSNP: 54331
ClinVar: 54331
TCGA: ENSG00000186469
COSMIC: GNG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186469ENST00000335281P59768
ENSG00000186469ENST00000553432G3V3J9
ENSG00000186469ENST00000553560G3V2C9
ENSG00000186469ENST00000554736P59768
ENSG00000186469ENST00000554875G3V415
ENSG00000186469ENST00000555472P59768
ENSG00000186469ENST00000556522G3V2W5
ENSG00000186469ENST00000556752P59768
ENSG00000186469ENST00000556766P59768
ENSG00000186469ENST00000557376G3V2N0
ENSG00000186469ENST00000615906P59768

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Pathways in cancerKEGGhsa05200
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cholinergic synapseKEGGhsa04725
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Presynaptic function of Kainate receptorsREACTOMER-HSA-500657
GABA receptor activationREACTOMER-HSA-977443
GABA B receptor activationREACTOMER-HSA-977444
Activation of GABAB receptorsREACTOMER-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsREACTOMER-HSA-997272
Potassium ChannelsREACTOMER-HSA-1296071
Inwardly rectifying K+ channelsREACTOMER-HSA-1296065
G protein gated Potassium channelsREACTOMER-HSA-1296059
Activation of G protein gated Potassium channelsREACTOMER-HSA-1296041
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Prostacyclin signalling through prostacyclin receptorREACTOMER-HSA-392851
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 12REACTOMER-HSA-392170
ADP signalling through P2Y purinoceptor 1REACTOMER-HSA-418592
Thromboxane signalling through TP receptorREACTOMER-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
G-protein beta:gamma signallingREACTOMER-HSA-397795
G beta:gamma signalling through PI3KgammaREACTOMER-HSA-392451
G beta:gamma signalling through PLC betaREACTOMER-HSA-418217
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Aquaporin-mediated transportREACTOMER-HSA-445717
Vasopressin regulates renal water homeostasis via AquaporinsREACTOMER-HSA-432040
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretionREACTOMER-HSA-400042
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33384PLCB1GenePathwayassociated
PA33385PLCB2GenePathwayassociated
PA33386PLCB3GenePathwayassociated
PA33387PLCB4GenePathwayassociated
PA447199Bipolar DisorderDiseaseLiterature, MultilinkAnnotationassociated24718920

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
180458772008Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.26
174929412007Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport.22
259413812015G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.22
229571042012Topography of Gng2- and NetrinG2-expression suggests an insular origin of the human claustrum.15
200077122010Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
151054222004A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels.8
201810832010Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition.8
216794692011Gβγ subunits inhibit Epac-induced melanoma cell migration.7

Citation

Dessen P

GNG2 (G protein subunit gamma 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43293/gng2