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GNG4 (G protein subunit gamma 4)

Identity

Alias_namesguanine nucleotide binding protein (G protein)
Other alias-
HGNC (Hugo) GNG4
LocusID (NCBI) 2786
Atlas_Id 43294
Location 1q42.3  [Link to chromosome band 1q42]
Location_base_pair Starts at 235710985 and ends at 235814054 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATF6B (6p21.33) / GNG4 (1q42.3)GNG4 (1q42.3) / PSMD10 (Xq22.3)GNG4 (1q42.3) / SORBS1 (10q24.1)
LOC100507412 (-) / GNG4 (1q42.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNG4   4407
Cards
Entrez_Gene (NCBI)GNG4  2786  G protein subunit gamma 4
Aliases
GeneCards (Weizmann)GNG4
Ensembl hg19 (Hinxton)ENSG00000168243 [Gene_View]  chr1:235710985-235814054 [Contig_View]  GNG4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168243 [Gene_View]  chr1:235710985-235814054 [Contig_View]  GNG4 [Vega]
ICGC DataPortalENSG00000168243
TCGA cBioPortalGNG4
AceView (NCBI)GNG4
Genatlas (Paris)GNG4
WikiGenes2786
SOURCE (Princeton)GNG4
Genetics Home Reference (NIH)GNG4
Genomic and cartography
GoldenPath hg19 (UCSC)GNG4  -     chr1:235710985-235814054 -  1q42.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GNG4  -     1q42.3   [Description]    (hg38-Dec_2013)
EnsemblGNG4 - 1q42.3 [CytoView hg19]  GNG4 - 1q42.3 [CytoView hg38]
Mapping of homologs : NCBIGNG4 [Mapview hg19]  GNG4 [Mapview hg38]
OMIM604388   
Gene and transcription
Genbank (Entrez)AF493872 AK074383 AK311781 AL832564 BC022485
RefSeq transcript (Entrez)NM_001098721 NM_001098722 NM_004485
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)GNG4
Cluster EST : UnigeneHs.159711 [ NCBI ]
CGAP (NCI)Hs.159711
Alternative Splicing GalleryENSG00000168243
Gene ExpressionGNG4 [ NCBI-GEO ]   GNG4 [ EBI - ARRAY_EXPRESS ]   GNG4 [ SEEK ]   GNG4 [ MEM ]
Gene Expression Viewer (FireBrowse)GNG4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2786
GTEX Portal (Tissue expression)GNG4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50150   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50150  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50150
Splice isoforms : SwissVarP50150
PhosPhoSitePlusP50150
Domaine pattern : Prosite (Expaxy)G_PROTEIN_GAMMA (PS50058)   
Domains : Interpro (EBI)G-protein_gamma-like_dom    Gprotein-gamma   
Domain families : Pfam (Sanger)G-gamma (PF00631)   
Domain families : Pfam (NCBI)pfam00631   
Domain families : Smart (EMBL)GGL (SM00224)  
Conserved Domain (NCBI)GNG4
DMDM Disease mutations2786
Blocks (Seattle)GNG4
SuperfamilyP50150
Human Protein AtlasENSG00000168243
Peptide AtlasP50150
HPRD11978
IPIIPI00030058   
Protein Interaction databases
DIP (DOE-UCLA)P50150
IntAct (EBI)P50150
FunCoupENSG00000168243
BioGRIDGNG4
STRING (EMBL)GNG4
ZODIACGNG4
Ontologies - Pathways
QuickGOP50150
Ontology : AmiGOsignal transducer activity  protein binding  heterotrimeric G-protein complex  plasma membrane  G-protein coupled receptor signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  negative regulation of cell growth  extracellular exosome  cellular response to glucagon stimulus  
Ontology : EGO-EBIsignal transducer activity  protein binding  heterotrimeric G-protein complex  plasma membrane  G-protein coupled receptor signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  negative regulation of cell growth  extracellular exosome  cellular response to glucagon stimulus  
Pathways : KEGGRas signaling pathway    Chemokine signaling pathway    PI3K-Akt signaling pathway    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Morphine addiction    Alcoholism   
NDEx NetworkGNG4
Atlas of Cancer Signalling NetworkGNG4
Wikipedia pathwaysGNG4
Orthology - Evolution
OrthoDB2786
GeneTree (enSembl)ENSG00000168243
Phylogenetic Trees/Animal Genes : TreeFamGNG4
HOVERGENP50150
HOGENOMP50150
Homologs : HomoloGeneGNG4
Homology/Alignments : Family Browser (UCSC)GNG4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNG4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNG4
dbVarGNG4
ClinVarGNG4
1000_GenomesGNG4 
Exome Variant ServerGNG4
ExAC (Exome Aggregation Consortium)GNG4 (select the gene name)
Genetic variants : HAPMAP2786
Genomic Variants (DGV)GNG4 [DGVbeta]
DECIPHER (Syndromes)1:235710985-235814054  ENSG00000168243
CONAN: Copy Number AnalysisGNG4 
Mutations
ICGC Data PortalGNG4 
TCGA Data PortalGNG4 
Broad Tumor PortalGNG4
OASIS PortalGNG4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNG4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNG4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNG4
DgiDB (Drug Gene Interaction Database)GNG4
DoCM (Curated mutations)GNG4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNG4 (select a term)
intoGenGNG4
Cancer3DGNG4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604388   
Orphanet
MedgenGNG4
Genetic Testing Registry GNG4
NextProtP50150 [Medical]
TSGene2786
GENETestsGNG4
Huge Navigator GNG4 [HugePedia]
snp3D : Map Gene to Disease2786
BioCentury BCIQGNG4
ClinGenGNG4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2786
Chemical/Pharm GKB GenePA28786
Clinical trialGNG4
Miscellaneous
canSAR (ICR)GNG4 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNG4
EVEXGNG4
GoPubMedGNG4
iHOPGNG4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:02:40 CEST 2017

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