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GNG5 (G protein subunit gamma 5)

Identity

Alias (NCBI)-
HGNC (Hugo) GNG5
HGNC Previous nameguanine nucleotide binding protein (G protein), gamma 5
LocusID (NCBI) 2787
Atlas_Id 43295
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 84498325 and ends at 84506581 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTBS (1p22.3)::GNG5 (1p22.3)GNG5 (1p22.3)::CTBS (1p22.3)RPF1 (1p22.3)::GNG5 (1p22.3)
TTLL7 (1p31.1)::GNG5 (1p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p22;p22) CTBS::GNG5


External links

 

Nomenclature
HGNC (Hugo)GNG5   4408
Cards
Entrez_Gene (NCBI)GNG5    G protein subunit gamma 5
Aliases
GeneCards (Weizmann)GNG5
Ensembl hg19 (Hinxton)ENSG00000174021 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174021 [Gene_View]  ENSG00000174021 [Sequence]  chr1:84498325-84506581 [Contig_View]  GNG5 [Vega]
ICGC DataPortalENSG00000174021
TCGA cBioPortalGNG5
AceView (NCBI)GNG5
Genatlas (Paris)GNG5
SOURCE (Princeton)GNG5
Genetics Home Reference (NIH)GNG5
Genomic and cartography
GoldenPath hg38 (UCSC)GNG5  -     chr1:84498325-84506581 -  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNG5  -     1p22.3   [Description]    (hg19-Feb_2009)
GoldenPathGNG5 - 1p22.3 [CytoView hg19]  GNG5 - 1p22.3 [CytoView hg38]
ImmunoBaseENSG00000174021
Genome Data Viewer NCBIGNG5 [Mapview hg19]  
OMIM600874   
Gene and transcription
Genbank (Entrez)AF038955 AF493873 AK312111 BC003563 BM809260
RefSeq transcript (Entrez)NM_005274
Consensus coding sequences : CCDS (NCBI)GNG5
Gene ExpressionGNG5 [ NCBI-GEO ]   GNG5 [ EBI - ARRAY_EXPRESS ]   GNG5 [ SEEK ]   GNG5 [ MEM ]
Gene Expression Viewer (FireBrowse)GNG5 [ Firebrowse - Broad ]
GenevisibleExpression of GNG5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2787
GTEX Portal (Tissue expression)GNG5
Human Protein AtlasENSG00000174021-GNG5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63218   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63218  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63218
PhosPhoSitePlusP63218
Domaine pattern : Prosite (Expaxy)G_PROTEIN_GAMMA (PS50058)   
Domains : Interpro (EBI)G-protein_gamma-like_dom    GGL_sf    Gprotein-gamma   
Domain families : Pfam (Sanger)G-gamma (PF00631)   
Domain families : Pfam (NCBI)pfam00631   
Domain families : Smart (EMBL)GGL (SM00224)  
Conserved Domain (NCBI)GNG5
SuperfamilyP63218
AlphaFold pdb e-kbP63218   
Human Protein Atlas [tissue]ENSG00000174021-GNG5 [tissue]
HPRD11865
Protein Interaction databases
DIP (DOE-UCLA)P63218
IntAct (EBI)P63218
BioGRIDGNG5
STRING (EMBL)GNG5
ZODIACGNG5
Ontologies - Pathways
QuickGOP63218
Ontology : AmiGOGTPase activity  protein binding  heterotrimeric G-protein complex  heterotrimeric G-protein complex  plasma membrane  signal transduction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  membrane  PDZ domain binding  G-protein beta-subunit binding  extracellular exosome  
Ontology : EGO-EBIGTPase activity  protein binding  heterotrimeric G-protein complex  heterotrimeric G-protein complex  plasma membrane  signal transduction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  membrane  PDZ domain binding  G-protein beta-subunit binding  extracellular exosome  
Pathways : KEGGKEGG_CHEMOKINE_SIGNALING   
NDEx NetworkGNG5
Atlas of Cancer Signalling NetworkGNG5
Wikipedia pathwaysGNG5
Orthology - Evolution
OrthoDB2787
GeneTree (enSembl)ENSG00000174021
Phylogenetic Trees/Animal Genes : TreeFamGNG5
Homologs : HomoloGeneGNG5
Homology/Alignments : Family Browser (UCSC)GNG5
Gene fusions - Rearrangements
Fusion Cancer (Beijing)CTBS [1p22.3]  -  GNG5 [1p22.3]  [FUSC000003]  [FUSC000003]  [FUSC000003]  [FUSC000003]  [FUSC000003]  [FUSC000003]  [FUSC000003]  [FUSC000003]  [FUSC000003]
Fusion Cancer (Beijing)GNG5 [1p22.3]  -  CTBS [1p22.3]  [FUSC000010]  [FUSC000010]  [FUSC000010]  [FUSC000010]  [FUSC000010]  [FUSC000010]  [FUSC000010]  [FUSC000010]  [FUSC000010]
Fusion : QuiverGNG5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNG5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNG5
dbVarGNG5
ClinVarGNG5
MonarchGNG5
1000_GenomesGNG5 
Exome Variant ServerGNG5
GNOMAD BrowserENSG00000174021
Varsome BrowserGNG5
ACMGGNG5 variants
VarityP63218
Genomic Variants (DGV)GNG5 [DGVbeta]
DECIPHERGNG5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNG5 
Mutations
ICGC Data PortalGNG5 
TCGA Data PortalGNG5 
Broad Tumor PortalGNG5
OASIS PortalGNG5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNG5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGNG5
Mutations and Diseases : HGMDGNG5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGNG5
DgiDB (Drug Gene Interaction Database)GNG5
DoCM (Curated mutations)GNG5
CIViC (Clinical Interpretations of Variants in Cancer)GNG5
Cancer3DGNG5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600874   
Orphanet
DisGeNETGNG5
MedgenGNG5
Genetic Testing Registry GNG5
NextProtP63218 [Medical]
GENETestsGNG5
Target ValidationGNG5
Huge Navigator GNG5 [HugePedia]
ClinGenGNG5
Clinical trials, drugs, therapy
MyCancerGenomeGNG5
Protein Interactions : CTDGNG5
Pharm GKB GenePA28787
Pharm GKB PathwaysPA2024   
PharosP63218
Clinical trialGNG5
Miscellaneous
canSAR (ICR)GNG5
HarmonizomeGNG5
ARCHS4GNG5
DataMed IndexGNG5
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGNG5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:35:26 CET 2022

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