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GNL2 (G protein nucleolar 2)

Identity

Alias_namesguanine nucleotide binding protein-like 2 (nucleolar)
Alias_symbol (synonym)Ngp-1
HUMAUANTIG
Nog2
Nug2
Other aliasNGP1
HGNC (Hugo) GNL2
LocusID (NCBI) 29889
Atlas_Id 54335
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 37566812 and ends at 37595985 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DLGAP1 (18p11.31) / GNL2 (1p34.3)GNL2 (1p34.3) / DNAH3 (16p12.3)GNL2 (1p34.3) / RNF216 (7p22.1)
LPP (3q28) / GNL2 (1p34.3)SF3A3 (1p34.3) / GNL2 (1p34.3)GNL2 1p34.3 / DNAH3 16p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)GNL2   29925
Cards
Entrez_Gene (NCBI)GNL2  29889  G protein nucleolar 2
AliasesHUMAUANTIG; NGP1; Ngp-1; Nog2; 
Nug2
GeneCards (Weizmann)GNL2
Ensembl hg19 (Hinxton)ENSG00000134697 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134697 [Gene_View]  chr1:37566812-37595985 [Contig_View]  GNL2 [Vega]
ICGC DataPortalENSG00000134697
TCGA cBioPortalGNL2
AceView (NCBI)GNL2
Genatlas (Paris)GNL2
WikiGenes29889
SOURCE (Princeton)GNL2
Genetics Home Reference (NIH)GNL2
Genomic and cartography
GoldenPath hg38 (UCSC)GNL2  -     chr1:37566812-37595985 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNL2  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblGNL2 - 1p34.3 [CytoView hg19]  GNL2 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIGNL2 [Mapview hg19]  GNL2 [Mapview hg38]
OMIM609365   
Gene and transcription
Genbank (Entrez)AA766044 AK130697 AK298358 AK307352 AK312915
RefSeq transcript (Entrez)NM_001323623 NM_001323624 NM_013285
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNL2
Cluster EST : UnigeneHs.75528 [ NCBI ]
CGAP (NCI)Hs.75528
Alternative Splicing GalleryENSG00000134697
Gene ExpressionGNL2 [ NCBI-GEO ]   GNL2 [ EBI - ARRAY_EXPRESS ]   GNL2 [ SEEK ]   GNL2 [ MEM ]
Gene Expression Viewer (FireBrowse)GNL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29889
GTEX Portal (Tissue expression)GNL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13823   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13823  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13823
Splice isoforms : SwissVarQ13823
PhosPhoSitePlusQ13823
Domaine pattern : Prosite (Expaxy)G_CP (PS51721)   
Domains : Interpro (EBI)G_CP_dom    GTP-bd_ortho_bundle    GTP_binding_domain    NOG2    NOG2_N_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)MMR_HSR1 (PF01926)    NGP1NT (PF08153)   
Domain families : Pfam (NCBI)pfam01926    pfam08153   
Conserved Domain (NCBI)GNL2
DMDM Disease mutations29889
Blocks (Seattle)GNL2
SuperfamilyQ13823
Human Protein AtlasENSG00000134697
Peptide AtlasQ13823
HPRD11006
IPIIPI00015808   IPI01014625   IPI01012954   
Protein Interaction databases
DIP (DOE-UCLA)Q13823
IntAct (EBI)Q13823
FunCoupENSG00000134697
BioGRIDGNL2
STRING (EMBL)GNL2
ZODIACGNL2
Ontologies - Pathways
QuickGOQ13823
Ontology : AmiGORNA binding  GTPase activity  GTP binding  nucleus  nucleolus  biological_process  membrane  ribosome biogenesis  
Ontology : EGO-EBIRNA binding  GTPase activity  GTP binding  nucleus  nucleolus  biological_process  membrane  ribosome biogenesis  
Pathways : KEGGRibosome biogenesis in eukaryotes   
NDEx NetworkGNL2
Atlas of Cancer Signalling NetworkGNL2
Wikipedia pathwaysGNL2
Orthology - Evolution
OrthoDB29889
GeneTree (enSembl)ENSG00000134697
Phylogenetic Trees/Animal Genes : TreeFamGNL2
HOVERGENQ13823
HOGENOMQ13823
Homologs : HomoloGeneGNL2
Homology/Alignments : Family Browser (UCSC)GNL2
Gene fusions - Rearrangements
Fusion : MitelmanGNL2/DNAH3 [1p34.3/16p12.3]  
Fusion : MitelmanSF3A3/GNL2 [1p34.3/1p34.3]  [t(1;1)(p34;p34)]  
Fusion: TCGAGNL2 1p34.3 DNAH3 16p12.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNL2
dbVarGNL2
ClinVarGNL2
1000_GenomesGNL2 
Exome Variant ServerGNL2
ExAC (Exome Aggregation Consortium)GNL2 (select the gene name)
Genetic variants : HAPMAP29889
Genomic Variants (DGV)GNL2 [DGVbeta]
DECIPHERGNL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNL2 
Mutations
ICGC Data PortalGNL2 
TCGA Data PortalGNL2 
Broad Tumor PortalGNL2
OASIS PortalGNL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNL2
DgiDB (Drug Gene Interaction Database)GNL2
DoCM (Curated mutations)GNL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNL2 (select a term)
intoGenGNL2
Cancer3DGNL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609365   
Orphanet
MedgenGNL2
Genetic Testing Registry GNL2
NextProtQ13823 [Medical]
TSGene29889
GENETestsGNL2
Target ValidationGNL2
Huge Navigator GNL2 [HugePedia]
snp3D : Map Gene to Disease29889
BioCentury BCIQGNL2
ClinGenGNL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29889
Chemical/Pharm GKB GenePA134944852
Clinical trialGNL2
Miscellaneous
canSAR (ICR)GNL2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNL2
EVEXGNL2
GoPubMedGNL2
iHOPGNL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:10:10 CEST 2017

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