GNL3 (G protein nucleolar 3)

2003-11-01  

Identity

HGNC
LOCATION
3p21.1
LOCUSID
ALIAS
C77032,E2IG3,NNP47,NS
FUSION GENES

Other Information

Locus ID:

NCBI: 26354
MIM: 608011
HGNC: 29931
Ensembl: ENSG00000163938

Variants:

dbSNP: 26354
ClinVar: 26354
TCGA: ENSG00000163938
COSMIC: GNL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163938ENST00000394799Q9BVP2
ENSG00000163938ENST00000418458Q9BVP2
ENSG00000163938ENST00000474423C9JYH9
ENSG00000163938ENST00000479230C9JZT7
ENSG00000163938ENST00000492349B4DMU5

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA445113NeutropeniaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA449476epirubicinChemicalClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
194169212009Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.114
184269072008Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2.96
156573902005A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin.76
174948662007Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway.59
170007632006Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability.57
184198302008Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells.50
162824392006Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow.44
191061112009Critical role of nucleostemin in pre-rRNA processing.43
158579562005A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin.39
217301562011Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.39

Citation

Dessen P

GNL3 (G protein nucleolar 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41584/gnl3