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GNLY (granulysin)

Identity

Alias_namesLAG2
Alias_symbol (synonym)NKG5
LAG-2
D2S69E
TLA519
Other alias
HGNC (Hugo) GNLY
LocusID (NCBI) 10578
Atlas_Id 43730
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85921414 and ends at 85925974 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATOH8 (2p11.2) / GNLY (2p11.2)GNLY (2p11.2) / PCBP1 (2p13.3)NPAS2 (2q11.2) / GNLY (2p11.2)
ATOH8 2p11.2 / GNLY 2p11.2NPAS2 2q11.2 / GNLY 2p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNLY   4414
Cards
Entrez_Gene (NCBI)GNLY  10578  granulysin
AliasesD2S69E; LAG-2; LAG2; NKG5; 
TLA519
GeneCards (Weizmann)GNLY
Ensembl hg19 (Hinxton)ENSG00000115523 [Gene_View]  chr2:85921414-85925974 [Contig_View]  GNLY [Vega]
Ensembl hg38 (Hinxton)ENSG00000115523 [Gene_View]  chr2:85921414-85925974 [Contig_View]  GNLY [Vega]
ICGC DataPortalENSG00000115523
TCGA cBioPortalGNLY
AceView (NCBI)GNLY
Genatlas (Paris)GNLY
WikiGenes10578
SOURCE (Princeton)GNLY
Genetics Home Reference (NIH)GNLY
Genomic and cartography
GoldenPath hg19 (UCSC)GNLY  -     chr2:85921414-85925974 +  2p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GNLY  -     2p11.2   [Description]    (hg38-Dec_2013)
EnsemblGNLY - 2p11.2 [CytoView hg19]  GNLY - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBIGNLY [Mapview hg19]  GNLY [Mapview hg38]
OMIM188855   
Gene and transcription
Genbank (Entrez)AA883466 AK296106 AK304728 AK308781 AK310057
RefSeq transcript (Entrez)NM_001302758 NM_006433 NM_012483
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)GNLY
Cluster EST : UnigeneHs.105806 [ NCBI ]
CGAP (NCI)Hs.105806
Alternative Splicing GalleryENSG00000115523
Gene ExpressionGNLY [ NCBI-GEO ]   GNLY [ EBI - ARRAY_EXPRESS ]   GNLY [ SEEK ]   GNLY [ MEM ]
Gene Expression Viewer (FireBrowse)GNLY [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10578
GTEX Portal (Tissue expression)GNLY
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22749   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22749  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22749
Splice isoforms : SwissVarP22749
PhosPhoSitePlusP22749
Domaine pattern : Prosite (Expaxy)SAP_B (PS50015)   
Domains : Interpro (EBI)SapB_2    Saposin-like    SaposinB_dom   
Domain families : Pfam (Sanger)SapB_2 (PF03489)   
Domain families : Pfam (NCBI)pfam03489   
Domain families : Smart (EMBL)SapB (SM00741)  
Conserved Domain (NCBI)GNLY
DMDM Disease mutations10578
Blocks (Seattle)GNLY
PDB (SRS)1L9L   
PDB (PDBSum)1L9L   
PDB (IMB)1L9L   
PDB (RSDB)1L9L   
Structural Biology KnowledgeBase1L9L   
SCOP (Structural Classification of Proteins)1L9L   
CATH (Classification of proteins structures)1L9L   
SuperfamilyP22749
Human Protein AtlasENSG00000115523
Peptide AtlasP22749
HPRD01788
IPIIPI00301472   IPI00396242   IPI00908991   IPI00981516   
Protein Interaction databases
DIP (DOE-UCLA)P22749
IntAct (EBI)P22749
FunCoupENSG00000115523
BioGRIDGNLY
STRING (EMBL)GNLY
ZODIACGNLY
Ontologies - Pathways
QuickGOP22749
Ontology : AmiGOextracellular space  cellular defense response  killing of cells of other organism  defense response to bacterium  defense response to fungus  
Ontology : EGO-EBIextracellular space  cellular defense response  killing of cells of other organism  defense response to bacterium  defense response to fungus  
NDEx NetworkGNLY
Atlas of Cancer Signalling NetworkGNLY
Wikipedia pathwaysGNLY
Orthology - Evolution
OrthoDB10578
GeneTree (enSembl)ENSG00000115523
Phylogenetic Trees/Animal Genes : TreeFamGNLY
HOVERGENP22749
HOGENOMP22749
Homologs : HomoloGeneGNLY
Homology/Alignments : Family Browser (UCSC)GNLY
Gene fusions - Rearrangements
Fusion : MitelmanATOH8/GNLY [2p11.2/2p11.2]  [t(2;2)(p11;p11)]  
Fusion : MitelmanNPAS2/GNLY [2q11.2/2p11.2]  [t(2;2)(p11;q11)]  
Fusion: TCGAATOH8 2p11.2 GNLY 2p11.2 LUAD
Fusion: TCGANPAS2 2q11.2 GNLY 2p11.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNLY [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNLY
dbVarGNLY
ClinVarGNLY
1000_GenomesGNLY 
Exome Variant ServerGNLY
ExAC (Exome Aggregation Consortium)GNLY (select the gene name)
Genetic variants : HAPMAP10578
Genomic Variants (DGV)GNLY [DGVbeta]
DECIPHER (Syndromes)2:85921414-85925974  ENSG00000115523
CONAN: Copy Number AnalysisGNLY 
Mutations
ICGC Data PortalGNLY 
TCGA Data PortalGNLY 
Broad Tumor PortalGNLY
OASIS PortalGNLY [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNLY  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNLY
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNLY
DgiDB (Drug Gene Interaction Database)GNLY
DoCM (Curated mutations)GNLY (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNLY (select a term)
intoGenGNLY
Cancer3DGNLY(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188855   
Orphanet
MedgenGNLY
Genetic Testing Registry GNLY
NextProtP22749 [Medical]
TSGene10578
GENETestsGNLY
Huge Navigator GNLY [HugePedia]
snp3D : Map Gene to Disease10578
BioCentury BCIQGNLY
ClinGenGNLY
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10578
Chemical/Pharm GKB GenePA28793
Clinical trialGNLY
Miscellaneous
canSAR (ICR)GNLY (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNLY
EVEXGNLY
GoPubMedGNLY
iHOPGNLY
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:02:42 CEST 2017

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