GNRH1 (gonadotropin releasing hormone 1)

2007-02-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
GNRH,GRH,LHRH,LNRH

Other Information

Locus ID:

NCBI: 2796
MIM: 152760
HGNC: 4419
Ensembl: ENSG00000147437

Variants:

dbSNP: 2796
ClinVar: 2796
TCGA: ENSG00000147437
COSMIC: GNRH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147437ENST00000276414P01148
ENSG00000147437ENST00000421054P01148

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
GnRH signaling pathwayKEGGko04912
GnRH signaling pathwayKEGGhsa04912
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205291192010The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons.65
195357952009Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation.63
195678352009GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism.54
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
201189842010Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer.37
240561712014GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression.36
209516832010Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus.35
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
189597382008Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues.33
174565752007Gonadotropin-releasing hormone neurons express estrogen receptor-beta.28

Citation

Dessen P

GNRH1 (gonadotropin releasing hormone 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43708/gnrh1