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GNRH1 (gonadotropin releasing hormone 1)

Identity

Alias_namesGRH
GNRH
LHRH
leuteinizing-releasing hormone
Other aliasLNRH
HGNC (Hugo) GNRH1
LocusID (NCBI) 2796
Atlas_Id 43708
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 25419258 and ends at 25425040 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNRH1   4419
Cards
Entrez_Gene (NCBI)GNRH1  2796  gonadotropin releasing hormone 1
AliasesGNRH; GRH; LHRH; LNRH
GeneCards (Weizmann)GNRH1
Ensembl hg19 (Hinxton)ENSG00000147437 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147437 [Gene_View]  chr8:25419258-25425040 [Contig_View]  GNRH1 [Vega]
ICGC DataPortalENSG00000147437
TCGA cBioPortalGNRH1
AceView (NCBI)GNRH1
Genatlas (Paris)GNRH1
WikiGenes2796
SOURCE (Princeton)GNRH1
Genetics Home Reference (NIH)GNRH1
Genomic and cartography
GoldenPath hg38 (UCSC)GNRH1  -     chr8:25419258-25425040 -  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNRH1  -     8p21.2   [Description]    (hg19-Feb_2009)
EnsemblGNRH1 - 8p21.2 [CytoView hg19]  GNRH1 - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBIGNRH1 [Mapview hg19]  GNRH1 [Mapview hg38]
OMIM146110   152760   
Gene and transcription
Genbank (Entrez)AL047164 BC067290 BC126437 BC126463 CB243067
RefSeq transcript (Entrez)NM_000825 NM_001083111
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNRH1
Cluster EST : UnigeneHs.82963 [ NCBI ]
CGAP (NCI)Hs.82963
Alternative Splicing GalleryENSG00000147437
Gene ExpressionGNRH1 [ NCBI-GEO ]   GNRH1 [ EBI - ARRAY_EXPRESS ]   GNRH1 [ SEEK ]   GNRH1 [ MEM ]
Gene Expression Viewer (FireBrowse)GNRH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2796
GTEX Portal (Tissue expression)GNRH1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01148   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01148  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01148
Splice isoforms : SwissVarP01148
PhosPhoSitePlusP01148
Domaine pattern : Prosite (Expaxy)GNRH (PS00473)   
Domains : Interpro (EBI)GnRH    Gonadoliberin_I    Gonadoliberin_I_precursor   
Domain families : Pfam (Sanger)GnRH (PF00446)   
Domain families : Pfam (NCBI)pfam00446   
Conserved Domain (NCBI)GNRH1
DMDM Disease mutations2796
Blocks (Seattle)GNRH1
SuperfamilyP01148
Human Protein AtlasENSG00000147437
Peptide AtlasP01148
HPRD08860
IPIIPI00000102   
Protein Interaction databases
DIP (DOE-UCLA)P01148
IntAct (EBI)P01148
FunCoupENSG00000147437
BioGRIDGNRH1
STRING (EMBL)GNRH1
ZODIACGNRH1
Ontologies - Pathways
QuickGOP01148
Ontology : AmiGOhormone activity  gonadotropin hormone-releasing hormone activity  extracellular region  extracellular space  mitochondrion  Golgi-associated vesicle  signal transduction  cell-cell signaling  multicellular organism development  female pregnancy  aging  negative regulation of cell proliferation  regulation of gene expression  male sex determination  dendrite  response to corticosteroid  response to lipopolysaccharide  negative regulation of immature T cell proliferation  response to testosterone  response to prostaglandin E  response to potassium ion  negative regulation of apoptotic process  perikaryon  axon terminus  estrous cycle  response to ethanol  cytoplasmic side of rough endoplasmic reticulum membrane  neurosecretory vesicle  response to prolactin  regulation of ovarian follicle development  negative regulation of neuron migration  
Ontology : EGO-EBIhormone activity  gonadotropin hormone-releasing hormone activity  extracellular region  extracellular space  mitochondrion  Golgi-associated vesicle  signal transduction  cell-cell signaling  multicellular organism development  female pregnancy  aging  negative regulation of cell proliferation  regulation of gene expression  male sex determination  dendrite  response to corticosteroid  response to lipopolysaccharide  negative regulation of immature T cell proliferation  response to testosterone  response to prostaglandin E  response to potassium ion  negative regulation of apoptotic process  perikaryon  axon terminus  estrous cycle  response to ethanol  cytoplasmic side of rough endoplasmic reticulum membrane  neurosecretory vesicle  response to prolactin  regulation of ovarian follicle development  negative regulation of neuron migration  
Pathways : KEGGGnRH signaling pathway   
NDEx NetworkGNRH1
Atlas of Cancer Signalling NetworkGNRH1
Wikipedia pathwaysGNRH1
Orthology - Evolution
OrthoDB2796
GeneTree (enSembl)ENSG00000147437
Phylogenetic Trees/Animal Genes : TreeFamGNRH1
HOVERGENP01148
HOGENOMP01148
Homologs : HomoloGeneGNRH1
Homology/Alignments : Family Browser (UCSC)GNRH1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNRH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNRH1
dbVarGNRH1
ClinVarGNRH1
1000_GenomesGNRH1 
Exome Variant ServerGNRH1
ExAC (Exome Aggregation Consortium)GNRH1 (select the gene name)
Genetic variants : HAPMAP2796
Genomic Variants (DGV)GNRH1 [DGVbeta]
DECIPHERGNRH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNRH1 
Mutations
ICGC Data PortalGNRH1 
TCGA Data PortalGNRH1 
Broad Tumor PortalGNRH1
OASIS PortalGNRH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNRH1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGNRH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNRH1
DgiDB (Drug Gene Interaction Database)GNRH1
DoCM (Curated mutations)GNRH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNRH1 (select a term)
intoGenGNRH1
Cancer3DGNRH1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146110    152760   
Orphanet8668   
MedgenGNRH1
Genetic Testing Registry GNRH1
NextProtP01148 [Medical]
TSGene2796
GENETestsGNRH1
Target ValidationGNRH1
Huge Navigator GNRH1 [HugePedia]
snp3D : Map Gene to Disease2796
BioCentury BCIQGNRH1
ClinGenGNRH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2796
Chemical/Pharm GKB GenePA28798
Clinical trialGNRH1
Miscellaneous
canSAR (ICR)GNRH1 (select the gene name)
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNRH1
EVEXGNRH1
GoPubMedGNRH1
iHOPGNRH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:35:37 CEST 2017

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